Gene: Osm

Order

Name oncostatin M

Synonyms OncoM

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:104749    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Osm

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Osm data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
thrombocytopenia Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 1.06E-12
increased mean corpuscular volume Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 3.06E-8
abnormal sleep behavior Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 8.52E-7
increased leukocyte cell number Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 2.01E-6
decreased circulating glucose level Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 4.8E-6
increased mean corpuscular hemoglobin Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 1.14E-5
decreased circulating triglyceride level Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 1.41E-5
decreased circulating free fatty acid level Osmtm1b(KOMP)Wtsi HOM Female Male postnatal 3.07E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Bone marrow 1 No
Brain 2 No (6/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No (4/393)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Submandibular gland 2 No (1/104) (1/2)
Testis 2 No (4/562) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Urinary bladder 2 No
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    digestive system
    reproductive system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482)
Dorsal root ganglion 2 (1/45)
Ear 2 (1/482)
Embryo 2 (1/482)
Eye 2 (1/482)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Fronto-nasal process 2 (1/46)
Hand 2 (1/482)
Head 2 (5/482)
Heart 2 (1/482)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Nose 2 (1/47)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Spinal cord 2 (1/46)
Tail 2 (1/482)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    10 Images
  • Sleep Wake: Wake state (bmp file)
    15 Images
  • Combined SHIRPA and Dysmorphology
    3 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Osmtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Osmtm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Osmtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene