Gene: Eps15

Order

Name epidermal growth factor receptor pathway substrate 15

Synonyms 2410112D09Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:104583    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Eps15

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Eps15 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased circulating LDL cholesterol level Eps15tm1a(KOMP)Wtsi HOM Female Male postnatal 4.84E-5
increased circulating HDL cholesterol level Eps15tm1a(KOMP)Wtsi HOM Female Male postnatal 5.24E-5
decreased hemoglobin content Eps15tm1a(KOMP)Wtsi HOM Female Male postnatal 5.4E-5
decreased mean corpuscular hemoglobin Eps15tm1a(KOMP)Wtsi HOM Female postnatal 8.43E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 0 No (2/2)
Aorta 0 No
Blood vessel 0 No (2/2)
Bone 0 No
Brain 0 No (2/2)
Brainstem 0 No
Brown adipose tissue 0 No
Cartilage tissue 0 No (2/2)
Cerebellum 0 No
Cerebral cortex 0 No
Eye 0 No (2/2)
Gall bladder 0 No (2/2)
Heart 0 No (2/2)
Hippocampus 0 No
Hypothalamus 0 No
Kidney 0 No (18/584) (2/2)
Large intestine 0 No (10/584) (2/2)
Liver 0 No
Lower urinary tract 0 No (2/2)
Lung 0 No (2/2)
Lymph node 0 No (2/2)
Mammary gland 0 No
Esophagus 0 No (2/2)
Olfactory lobe 0 No
Ovary 0 No (1/584) (1/2)
Oviduct 0 No (1/2)
Pancreas 0 No (5/584) (2/2)
Parathyroid gland 0 No (1/2)
Peripheral nervous system 0 No (2/2)
Peyer's patch 0 No (1/2)
Pituitary gland 0 No (2/2)
Prostate gland 0 No (12/584) (1/2)
Skeletal muscle tissue 0 No
Skin 0 No (2/2)
Small intestine 0 No (9/584) (2/2)
Spinal cord 0 No (2/2)
Spleen 0 No (2/584) (1/2)
Stomach 0 No (12/584) (2/2)
Striatum 0 No
Testis 0 No (2/584) (1/2)
Thymus 0 No (2/2)
Thyroid gland 0 No (15/584) (1/2)
Trachea 0 No (2/2)
Uterus 0 No (1/2)
White adipose tissue 0 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (25)
  • Eps15tm1a(KOMP)Wtsi
    oesophagus, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    eye, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    blood vessel, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    pituitary gland, peripheral nervous system, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    skin, pinna, HOM, Female, WTSI

show all 25 images

trunk (16)
  • Eps15tm1a(KOMP)Wtsi
    oesophagus, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    large intestine, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    ovary, oviduct, uterus, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    adrenal gland, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    testis, HOM, Male, WTSI

show all 16 images

digestive system (4)
  • Eps15tm1a(KOMP)Wtsi
    oesophagus, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    large intestine, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    gall bladder, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    small intestine, HOM, Female, WTSI
nervous system (4)
  • Eps15tm1a(KOMP)Wtsi
    pituitary gland, peripheral nervous system, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    brain, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    brain, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    spinal cord, HOM, Female, WTSI
immune system (3)
  • Eps15tm1a(KOMP)Wtsi
    thymus, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    lymph node, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    spleen, HOM, Male, WTSI
reproductive system (3)
  • Eps15tm1a(KOMP)Wtsi
    ovary, oviduct, uterus, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    testis, HOM, Male, WTSI
  • Eps15tm1a(KOMP)Wtsi
    prostate gland, HOM, Male, WTSI
cardiovascular system (2)
  • Eps15tm1a(KOMP)Wtsi
    blood vessel, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    heart, HOM, Female, WTSI
integumental system (2)
  • Eps15tm1a(KOMP)Wtsi
    skin, pinna, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    skin, HOM, Female, WTSI
respiratory system (2)
  • Eps15tm1a(KOMP)Wtsi
    lung, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    trachea, HOM, Male, WTSI
sensory organ (2)
  • Eps15tm1a(KOMP)Wtsi
    eye, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    skin, pinna, HOM, Female, WTSI
endocrine system (1)
  • Eps15tm1a(KOMP)Wtsi
    adrenal gland, HOM, Female, WTSI
exocrine system (1)
  • Eps15tm1a(KOMP)Wtsi
    prostate gland, HOM, Male, WTSI
urinary system (1)
  • Eps15tm1a(KOMP)Wtsi
    kidney, HOM, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (68)
  • Eps15tm1a(KOMP)Wtsi
    body, HOM, Male, WTSI
  • Eps15tm1a(KOMP)Wtsi
    head, HOM, Male, WTSI
  • Eps15tm1a(KOMP)Wtsi
    head, HOM, Male, WTSI
  • Eps15tm1a(KOMP)Wtsi
    forearm, HOM, Male, WTSI
  • Eps15tm1a(KOMP)Wtsi
    body, HOM, Male, WTSI

show all 68 images

Skin Histopathology (3)
  • Eps15tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Eps15tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Eps15tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Eps15tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Eps15tm357289(L1L2_Bact_P)
Vector
Gene