Gene: Myo7a

Name myosin VIIA

Synonyms
  • Hdb
  • nmf371
  • polka
  • USH1B
  • Myo7

Status ES CellsMice
tm1a
phenotype data available

Links MGI:104510   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Myo7a

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Myo7a data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased or absent threshold for auditory brainstem response Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased body weight Myo7aHdb HOM Female Male postnatal 9.4E-42
trunk curl Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.98E-18
absent pinna reflex Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.21E-17
stereotypic behavior Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.44E-15
increased total body fat amount Myo7aHdb HOM Female Male postnatal 3.9E-9
abnormal bone mineralization Myo7aHdb HOM Female Male postnatal 1.27E-8
increased lean body mass Myo7aHdb HOM Female Male postnatal 1.56E-8
abnormal behavior Myo7aHdb HOM Female Male postnatal 3.59E-8
impaired righting response Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 6.54E-8
abnormal locomotor activation Myo7aHdb HOM Female Male postnatal 5.49E-7
increased blood urea nitrogen level Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.05E-6
abnormal bone structure Myo7aHdb HOM Female Male postnatal 1.97E-5
persistence of hyaloid vascular system Myo7atm1a(EUCOMM)Wtsi HOM Female postnatal 2.58E-5
increased circulating sodium level Myo7atm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.8E-5
increased thermal nociceptive threshold Myo7aHdb HOM Female Male postnatal 5.4E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    40 Images
  • X-ray: XRay Images Forepaw
    12 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
Legacy Phenotype Associated Images
Xray (478)
  • Myo7aHdb
    LOWER ARM, WT, Female, WTSI
  • Myo7aHdb
    TRUNK, HOM, Female, WTSI
  • Myo7aHdb
    TRUNK, HOM, Female, WTSI
  • Myo7aHdb
    HEAD, HOM, Female, WTSI
  • Myo7aHdb
    HEAD, HOM, Female, WTSI

show all 478 images

Tail Epidermis Wholemount (9)
  • Myo7aHdb
    HOM, Female, WTSI
  • Myo7aHdb
    WT, Female, WTSI
  • Myo7aHdb
    WT, Female, WTSI
  • Myo7aHdb
    HOM, Female, WTSI
  • Myo7ash1-6J
    abnormal sebaceous gland morphology, HET, Female, WTSI

show all 9 images

Eye Morphology (8)
  • Myo7aHdb
    EYE, cataracts, HOM, Female, WTSI
  • Myo7aHdb
    EYE, cataracts, HOM, Female, WTSI
  • Myo7ash1-6J
    EYE, corneal opacity, HOM, Female, WTSI
  • Myo7atm1a(EUCOMM)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI
  • Myo7atm1a(EUCOMM)Wtsi
    HOM, Female, WTSI

show all 8 images

Skin Histopathology (7)
  • Myo7ash1-6J
    HET, Female, WTSI
  • Myo7ash1-6J
    HOM, Female, WTSI
  • Myo7ash1-6J
    HOM, Female, WTSI
  • Myo7ash1-6J
    HOM, Female, WTSI
  • Myo7ash1-6J
    HET, Female, WTSI

show all 7 images

Dysmorphology (1)
  • Myo7atm1a(EUCOMM)Wtsi
    AUTOPOD, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Myo7atm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Myo7atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene