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Gene: Slk MGI:103241

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Gene Summary

Name:
STE20-like kinase
Synonyms:
Etk4,  9A2,  mSLK,  Stk2,  SLK

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Slkem1(IMPC)Bay HET E9.5 0.00
prenatal lethality Slkem1(IMPC)Bay HOM   E18.5 0.00
embryonic growth retardation Slkem1(IMPC)Bay HET E9.5 0.00
preweaning lethality, complete penetrance Slkem1(IMPC)Bay HOM   Early adult 0.00
increased vertical activity Slkem1(IMPC)Bay HET   Early adult 6.37×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

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MicroCT E9.5

Embryo reconstruction

5 Images

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MicroCT E18.5

Embryo reconstruction

1 Images

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MicroCT E14.5-E15.5

Embryo reconstruction

1 Images

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Human diseases caused by Slk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Slk by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Schizophrenia 15
Hyperactivity OMIM:613950
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Gilles De La Tourette Syndrome
Aggressive behavior, Phonic tics, Attention deficit hyperactivity disorder, Compulsive behaviors,... OMIM:137580
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Muscular Hypertrophy-Hepatomegaly-Polyhydramnios Syndrome
Occipital encephalocele, Hydrocephalus, Congenital muscular dystrophy, Coloboma ORPHA:324416
Congenital Muscular Dystrophy With Cerebellar Involvement
Occipital encephalocele, Calf muscle pseudohypertrophy, Hypoglycosylation of alpha-dystroglycan, ... ORPHA:370959
Frontonasal Dysplasia 1
Postaxial hand polydactyly, Anterior basal encephalocele, Coloboma, Pectoral muscle hypoplasia/ap... OMIM:136760
Joubert Syndrome 15
Coloboma, Preaxial polydactyly, Exencephaly OMIM:614464
Biemond Syndrome Type 2
Short stature, Hydrocephalus, Preaxial polydactyly, Coloboma, Delayed puberty ORPHA:141333
Joubert Syndrome 16
Encephalocele, Coloboma, Polydactyly OMIM:614465
Verheij Syndrome
Branchial cyst, Short stature, Optic nerve hypoplasia, Growth delay, Coloboma, Short 5th finger, ... OMIM:615583
Joubert Syndrome 14
Encephalocele, Postaxial polydactyly, Hydrocephalus, Meningocele, Optic atrophy, Growth delay, Co... OMIM:614424
Coach Syndrome 2
Elevated hepatic transaminase, Hydrocephalus, Coloboma, Hypertension, Chorioretinal coloboma OMIM:619111
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Short femur, Anterior encephalocele, Coloboma, Foot oligodactyly, Holoprosencephaly OMIM:601357
Coach Syndrome 1
Encephalocele, Occipital encephalocele, Optic disc pallor, Elevated hepatic transaminase, Portal ... OMIM:216360
Histidinemia
Hyperactivity ORPHA:2157
Phakomatosis Pigmentokeratotica
Rhabdomyosarcoma, Spina bifida, Raynaud phenomenon, Coloboma, Hemiatrophy, Arrhythmia ORPHA:2874
Roberts-Sc Phocomelia Syndrome
Knee flexion contracture, Coloboma, Wrist flexion contracture, Hypoplasia of the ulna, Syndactyly... OMIM:268300

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slk.

No publications found that use IMPC mice or data for Slk.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Slktm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Slkem1(IMPC)Bay Exon Deletion Mice
Slktm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Slktm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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