Gene: Runx3

Order

Name runt related transcription factor 3

Synonyms
  • AML2
  • Cbfa3

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:102672    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Runx3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Runx3 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Runx3tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
abnormal locomotor behavior Runx3tm1b(KOMP)Wtsi HET Female postnatal 3.24E-10

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Epididymis 2 No (18/134)
Esophagus 2 No (7/415)
Eye 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584) (1/2)
Stomach 2 No (12/584)
Striatum 2 No
Submandibular gland 2 No (2/132) (1/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No
Uterus 2 No
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    digestive system
    reproductive system
    immune system
    exocrine system
    integumental system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/3)
Dorsal root ganglion 2 (1/47) Image Only
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485) (2/3)
Fronto-nasal process 2 (1/48) Image Only
Hand 2 (1/485)
Head 2 (5/485) (2/3)
Heart 2 (1/485)
Hindbrain 2 (6/485) (2/3)
Hindlimb 2 (1/485) (2/3)
Liver 2 (1/485)
Lung 2 (1/485) Image Only
Mandibular process 2 (1/485) (2/3)
Maxillary process 2 (1/485) (2/3)
Midbrain 2 (1/485)
Nose 2 (1/51) (2/3)
Oral cavity 2 (1/485) Image Only
Skin 2 (1/485)
Spinal cord 2 (1/50) (2/3)
Tail 2 (1/485) (2/3)
Tail somite 2 (1/485)
Vibrissa 2 (1/47) (2/2)


Associated Images

Associated Images
  • Sleep Wake: Wake state (bmp file)
    9 Images
  • Gross Morphology Embryo E18.5
    2 Images
  • Electroretinography 2: Rod and cone PDF
    4 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Runx3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Runx3tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene