Gene: Ppp5c

Order

Name protein phosphatase 5, catalytic subunit

Synonyms
  • PP5
  • ANP receptor

Status ES CellsMice
tm1a
phenotype data available

Links MGI:102666    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Ppp5c

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ppp5c data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased T cell number Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.04E-17
decreased body length Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.17E-10
increased total body fat amount Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.13E-9
decreased body weight Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.75E-9
increased lean body mass Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.59E-8
abnormal rib morphology Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.31E-8
decreased circulating triglyceride level Ppp5ctm1a(EUCOMM)Wtsi HOM Male postnatal 1.41E-7
abnormal coat/hair pigmentation Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.28E-6
decreased circulating glucose level Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 5.47E-6
abnormal bone structure Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 7.82E-6
vertebral fusion Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.23E-5
increased CD8-positive, alpha-beta T cell number Ppp5ctm1a(EUCOMM)Wtsi HOM Female Male postnatal 9.49E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No
Heart 2 No (1/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (1/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No (1/2)
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (1/2)
Parathyroid gland 2 No (1/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (1/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (1/2)
Trachea 2 No
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system cardiovascular system nervous system reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (8)
  • Ppp5ctm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    oviduct, ovary, uterus, HET, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    lower urinary tract, HET, Female, WTSI

show all 8 images

trunk (5)
  • Ppp5ctm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    oviduct, ovary, uterus, HET, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    pancreas, HET, Female, WTSI
reproductive system (2)
  • Ppp5ctm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    oviduct, ovary, uterus, HET, Female, WTSI
urinary system (2)
  • Ppp5ctm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    lower urinary tract, HET, Female, WTSI
cardiovascular system (1)
  • Ppp5ctm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
endocrine system (1)
  • Ppp5ctm1a(EUCOMM)Wtsi
    parathyroid gland, HET, Female, WTSI
nervous system (1)
  • Ppp5ctm1a(EUCOMM)Wtsi
    brain, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (155)
  • Ppp5ctm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    forearm, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI

show all 155 images

Eye Morphology (3)
  • Ppp5ctm1a(EUCOMM)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    eye, abnormal pupil morphology, mydriasis, HOM, Male, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    eye, abnormal placement of pupils, cataracts, abnormal pupil morphology, cornea/lens fusion, corneal opacity, HOM, Female, WTSI
Skin Histopathology (3)
  • Ppp5ctm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
  • Ppp5ctm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ppp5ctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene