Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  thickness 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Alanine aminotransferase 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.43025

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair distribution  back 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Echo / LVPWd 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.59158

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Electrocardiogram (ECG) / RR 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.0044116

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  whole body 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Trunk curl 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Brain 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Creatinine 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.83151

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of thoracic vertebrae 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_014_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Mean cell hemoglobin concentration 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.76542

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Radius 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Indirect Calorimetry / Total food intake 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.50477

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Fibula 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Percentage center time 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.18052

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Eosinophil differential count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.82872

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Shape of vertebrae 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thyroid 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Body length 
HET 
7f:6m 
Mixed Model framework, generalized least squares, equation withWeight 
8.5426E13

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Brachydactyly 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Vibrissae  presence 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Lower teeth appearance 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Scapulae 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  back paws 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimbs  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Periphery distance travelled 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.00040043

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Zygomatic bone 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Calcium 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.063417

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Echo / HR 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.021837

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Shape of ribs 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spleen 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Epididymis 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Contact righting 
HET 
8f:8m 
Fisher Exact Test framework 
0.020221

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Hematocrit 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.99224

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  ear 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Grip Strength / Forelimb and hindlimb grip strength normalised against body weight 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.29624

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  number 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Esophagus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair texture / appearance  head 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve 
HET 
7f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.036224

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color  abdomen 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI3 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.37864

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Fat mass 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.73559

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Phosphorus 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
1.3985E05

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindpaw  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tremor 
HET 
8f:8m 
Fisher Exact Test framework 
0.00012588

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Viability Primary Screen / Outcome 
HOM 
58f:53m 
Supplied as data 
0.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Viability Primary Screen / Outcome 
HOM 
58f:53m 
Supplied as data 
0.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Genitalia  morphology 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lymph node 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Large Unstained Cell (LUC) count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.90640

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Indirect Calorimetry / Total water intake 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.10920

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Lymphocyte cell count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.045842

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Head morphology 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Electrocardiogram (ECG) / ST 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.0026184

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Indirect Calorimetry / Respiratory Exchange Ratio 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.0062251

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Upper teeth appearance 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Center distance travelled 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.11773

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Triglycerides 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.0013892

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Clavicle 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Activity (body position) 
HET 
8f:8m 
Fisher Exact Test framework 
0.10707

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Platelet count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.62354

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Liver 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Digit integrity 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Thymus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  snout 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Total protein 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.46258

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Fat/Body weight 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.44805

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimbs  position 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of cervical vertebrae 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_013_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Latency to center entry 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.010775

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimbs  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Mammary gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Echo / LVIDd 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.16197

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Fusion of vertebrae 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Tibia 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  morphology 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color pattern  abdomen 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Aspartate aminotransferase 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.23927

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  length 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Eosinophil cell count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.43756

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Vocalization 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Grip Strength / Forelimb and hindlimb grip strength measurement mean 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.52918

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Hemoglobin 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.70580

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Whole arena resting time 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withWeight 
0.010196

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Syndactylism 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Teeth presence 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Electrocardiogram (ECG) / QTc 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.072479

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Grip Strength / Forelimb grip strength normalised against body weight 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.65451

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Head size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color pattern  back 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Center average speed 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.41169

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Heart Weight / Heart weight 
HET 
7f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.45717

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forepaw  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull) 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withWeight 
0.033982

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Neutrophil differential count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.011080

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  snout 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Prostate 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair texture / appearance  back 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Lung 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skin 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / HDLcholesterol 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.40679

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI2 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.077793

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / Response amplitude  S 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.81333

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Periphery average speed 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.0016906

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Processes on vertebrae 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Maxilla/Premaxilla 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Lymphocyte differential count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.067557

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Pancreas 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Mouth morphology 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Monocyte differential count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.32888

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Head bobbing 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Spinal cord 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Lean/Body weight 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.56605

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of ribs right 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_008_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  ear 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Distance travelled  total 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.00073003

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Snout size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Electrocardiogram (ECG) / PR 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.15402

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Total cholesterol 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.43960

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Genitalia  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Periphery permanence time 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.18052

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Albumin 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.50970

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  length 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Electrocardiogram (ECG) / HR 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.0045973

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge 
HET 
7f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.15508

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Echo / LVAWd 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.033355

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Aggression 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Number of center entries 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.018222

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Pelvis 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Adrenal gland 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Grip Strength / Forelimb grip strength measurement mean 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.31390

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Startle response 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimbs  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Mean cell volume 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.017268

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Gall bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color  back 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Femur 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  shape 
HET 
8f:8m 
Fisher Exact Test framework 
0.13163

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Center permanence time 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.18052

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindpaw  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Basophil cell count 
HET 
7f:8m 
Not processed 
1.0000

FAILED  testDataset returned an error, check log file 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull) 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withWeight 
0.75264

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Upper lip morphology 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Locomotor activity 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.12725

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Red blood cell count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.88512

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Skeletal muscle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  tail 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Vibrissae  appearance 
HET 
8f:8m 
Fisher Exact Test framework 
0.019691

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI1 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.41050

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Mandibles 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Neutrophil cell count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.61093

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Seminal vesicle 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Humerus 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  back paws 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Large intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Limb grasp 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  whole body 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of digits 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_028_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair distribution  abdomen 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Urea (Blood Urea Nitrogen  BUN) 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.12459

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color pattern  head 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Periphery resting time 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withWeight 
0.010480

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Genitalia  presence 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of lumbar vertebrae 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_015_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Ulna 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair distribution  head 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Uterus 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  number 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Alkaline phosphatase 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.015272

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  length 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Monocyte cell count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.83950

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb nail  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Number of rears  total 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.042365

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Unexpected behaviors 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Teeth 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  Global 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.19482

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of ribs left 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_009_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimbs  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin texture  front paws 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Bone Area 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.00036612

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  color  head 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Mean corpuscular hemoglobin 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.63512

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Echo / LVIDs 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.21660

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Stomach 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Hindlimb digit  shape 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration 
HET 
7f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.30475

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Large Unstained Cell (LUC) differential count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withWeight 
0.62877

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Heart 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Total bilirubin 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.34610

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimbs  position 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forepaw  size 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Fusion of ribs 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / BMC/Body weight 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.018223

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Trachea 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Lower lip morphology 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / Basophil differential count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.14661

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  front paws 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Testes 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Coat  hair texture / appearance  abdomen 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Urinary bladder 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Center resting time 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.86885

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Clinical Chemistry / Glucose 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.29344

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Joints 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Skull shape 
HET 
5f:5m 
Fisher Exact Test framework 
1.0000

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Echo / Fractional Shortening 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.80626

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb nail  number 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Kidney 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Gait 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Electrocardiogram (ECG) / QRS 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.94782

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Ears 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Small intestine 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Tail  presence 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Acoustic Startle and Prepulse Inhibition (PPI) / % Prepulse inhibition  PPI4 
HET 
8f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.51643

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Tibia length 
HET 
5f:5m 
Mixed Model framework, linear mixedeffects model, equation withWeight 
1.2388E05

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Body Composition (DEXA lean/fat) / Lean mass 
HET 
7f:5m 
Mixed Model framework, generalized least squares, equation withWeight 
0.31319

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Open Field / Whole arena average speed 
HET 
8f:7m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.019084

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Xray / Number of pelvic vertebrae 
HET 
5f:5m 
Not processed 
1.0000

FAILED  No variability in dependent variable 'IMPC_XRY_016_001'. 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Ovary 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Forelimb digit  number 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Hematology / White blood cell count 
HET 
7f:8m 
Mixed Model framework, generalized least squares, equation withoutWeight 
0.15184

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Combined SHIRPA and Dysmorphology / Skin color  tail 
HET 
8f:8m 
Fisher Exact Test framework 
1.0000

Not tested (No variation)  OK 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HET 
f:m 
Supplied as data 

Success 

Dnal4^{tm1b(EUCOMM)Wtsi} 
ICS 
Gross Pathology and Tissue Collection / Eye with optic nerve 
HET 
f:m 
Supplied as data 

Success 
