All nervous system phenotype, behavior/neurological phenotype data for Sdc2

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status Graph
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Periphery resting time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.013365 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Center permanence time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.33036 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Whole arena resting time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00018651 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Activity (body position) HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Head bobbing HOM 8f:8m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Sdc2tm1b(KOMP)Wtsi HMGU Grip Strength / Forelimb grip strength normalised against body weight HOM 7f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.028343 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Trunk curl HOM 8f:8m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Center resting time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.027727 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Locomotor activity HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.65475 Success
Sdc2tm1b(KOMP)Wtsi HMGU Eye Morphology / Optic Disc HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Center average speed HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.13124 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Contact righting HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Grip Strength / Forelimb and hindlimb grip strength normalised against body weight HOM 7f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0024444 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Distance travelled - total HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.26680 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Number of rears - total HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.74453 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Unexpected behaviors HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - Global HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.78060 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Periphery permanence time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.33068 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Gait HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.16749 Success
Sdc2tm1b(KOMP)Wtsi HMGU Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.81804 Success
Sdc2tm1b(KOMP)Wtsi HMGU Indirect Calorimetry / Total food intake HOM 2f:5m Not processed 1.0000 FAILED - Not enough data points in dependent variable 'IMPC_CAL_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Latency to center entry HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.12922 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Percentage center time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.33035 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Aggression HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Number of center entries HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.53588 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Tremor HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.41624 Success
Sdc2tm1b(KOMP)Wtsi HMGU Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.10014 Success
Sdc2tm1b(KOMP)Wtsi HMGU Grip Strength / Forelimb grip strength measurement mean HOM 7f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.54124 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Startle response HOM 8f:8m Fisher Exact Test framework 1.0000 Not tested (No variation) - OK
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Periphery average speed HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.13254 Success
Sdc2tm1b(KOMP)Wtsi HMGU Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI4 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.78716 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Limb grasp HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Eye Morphology / Pupil Light Response HOM 8f:8m Fisher Exact Test framework 1.0000 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Whole arena average speed HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.17964 Success
Sdc2tm1b(KOMP)Wtsi HMGU Rotarod / Latency to fall_Mean HOM 4f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.041448 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Center distance travelled HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.051993 Success
Sdc2tm1b(KOMP)Wtsi HMGU Combined SHIRPA and Dysmorphology / Vocalization HOM 8f:8m Fisher Exact Test framework 0.20029 Success
Sdc2tm1b(KOMP)Wtsi HMGU Open Field / Periphery distance travelled HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.76151 Success
Sdc2tm1b(KOMP)Wtsi HMGU Grip Strength / Forelimb and hindlimb grip strength measurement mean HOM 7f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.89976 Success

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