Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to G6pd2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency | Splenomegaly | OMIM:300908 |
The table below shows human diseases predicted to be associated to G6pd2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency | Lymphadenopathy | ORPHA:319600 | |
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1) | Abnormal lymph node morphology | OMIM:136580 | |
Immunodeficiency 38 With Basal Ganglia Calcification | Lymphadenopathy | OMIM:616126 | |
Reticuloendotheliosis, X-Linked | Hepatosplenomegaly, Lymphadenopathy | OMIM:312500 | |
Immunodeficiency 75 With Lymphoproliferation | Hepatosplenomegaly, Lymphadenopathy, Follicular hyperplasia | OMIM:619126 | |
Kimura Disease | Lymphadenopathy, Follicular hyperplasia | ORPHA:482 | |
Immunodeficiency 32A | Lymphadenitis, Lymphadenopathy | OMIM:614893 | |
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation | Generalized lymphadenopathy, Aplasia of the thymus, Splenomegaly, Lymph node hypoplasia, Absent t... | OMIM:602450 | |
Meige Disease | Lymph node hypoplasia, Absence of lymph node germinal center | ORPHA:90186 | |
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency | Lymph node hypoplasia, Absent tonsils | ORPHA:276 | |
Purine Nucleoside Phosphorylase Deficiency | Splenomegaly, Lymph node hypoplasia | OMIM:613179 | |
Agammaglobulinemia, X-Linked | Lymph node hypoplasia | OMIM:300755 | |
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency | Splenomegaly | OMIM:300908 |
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for G6pd2
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to G6pd2.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines. | Metabolites (August 2023) | G6pd2em1(IMPC)Tcp | PMC10456929 |
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. | NPJ systems biology and applications (May 2021) | G6pd2em1(IMPC)Tcp | PMC8163790 |
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MGI Allele | Allele Type | Produced |
---|---|---|
G6pd2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
G6pd2em1(IMPC)Tcp | Intra-exon deletion | Mice, Tissue |
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