This protocol is used when a Complete Mouse Pathology Phenotype is requested. It is used to standardize the collection, trimming and embedding of embryonic tissue.
Feather No. 4 Surgical Blade Handle
No. 4 Surgical Blade
Forceps
Blue Cassettes
Lense paper 10cmx10cm
Embryo Dissection
1. Dissect embryos from dam.
2. Place embryos in 37°C PBS (minus Ca/Mg) containing 1 ul of Heparin per 1ml PBS (stock concentration of Heparin at 1,000u/ml).
3. Remove extra-embryonic membranes and placenta and collect yolk sac for genotyping; cut umbilical vessels with small scissors.
4. Check embryos for bleeding after 5 minutes. If not visibly bleeding a clot may have formed at the end of the umbilical vessels. Remove clot by cutting vessels below the clot.
5. Allow embryos to bleed out (on rocker) in warm PBS/Heparin for a maximum of 15 min – can be less than 5min for E9.5.
6. Wash embryos 2x with PBS.
7. Ensure the embryos are dead (by exsanguination) before immersing in 4% paraformaldehyde fixative prepared in PBS (check for movement or response to stimulus). For E9.5 embryos fix 4 hours at 4oC or 2 hours at room temperature. Embryos should be fixed in 20 – 40 X volume of fixative to embryo volume.
8. When fixation is complete, remove fix and immerse and store embryos at 4oC in PBS containing sodium azide (0.1g/500ml PBS) until they are imaged.
Specimens are now ready to be cut at 4μm (one section is cut laterally to include kidney and one section is cut midline) and then stained with H&E on autostainer and coverslipper.
E9.5 Embryo Trimming into Cassettes for Processing
1. Cassette 1: Place embryo saggittaly in middle of lens paper and wrap gently making sure all edges are enclosed. Place in the labelled cassette.
2. Cassette 2: Cut placenta cross section through the midline (use umbilical cord as midline). Place both halves and yolk sac in lens paper and wrap gently making sure all edges are enclosed.
3. Proceed with steps 5-7 above.
4. Embed Cassette 1 embryo sagittally (on its side) in paraffin.
5. Embed Cassette 2 placenta (on cut surface) and yolk sac on edge (cross section).
6. Paraffin blocks are ready to be cut.
Embryo Orientation in Cassettes for Embedding
Embryos are embedded in paraffin with the cut surface down. Exceptions are noted in the table below*.
Block # | Tissue Sample(s) | Embedding Orientation | Number of Tissues |
1 | Whole Embryo | Sagittal (for two levels of section; one lateral to include kidney and one midline) | 1 |
2 | Whole Placenta | Cross section at midline through the umbilical cord | 1 |
Version | Type | Req. Upload | Req. Analysis | Annotation | Increment | Option | Ontology Options | Derived | Unit | Data Type | |
---|---|---|---|---|---|---|---|---|---|---|---|
Embryo (EMAP:2230) MP terms IMPC_HEL_001_001 | 1.0 | ontologyParameter | [MP:0001706] abnormal left-right axis patterning [MP:0001704] Abnormal dorsal-ventral axis patterning [MP:0005221] Abnormal rostral-caudal axis patterning | TEXT | |||||||
Embryo (EMAP:2230) process terms IMPC_HEL_002_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Embryo (EMAP:2230) Severity score IMPC_HEL_003_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Embryo (EMAP:2230) Descriptor PATO IMPC_HEL_004_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Embryo (EMAP:2230) Description IMPC_HEL_005_001 | 1.0 | simpleParameter | TEXT | ||||||||
Forebrain (EMAP:1293) MP terms IMPC_HEL_006_001 | 1.1 | ontologyParameter | [MP:0003232] abnormal forebrain development | TEXT | |||||||
Forebrain (EMAP:1293) process terms IMPC_HEL_007_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Forebrain (EMAP:1293) Severity score IMPC_HEL_008_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Forebrain (EMAP:1293) Desciptor PATO IMPC_HEL_009_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Forebrain (EMAP:1293) Description IMPC_HEL_010_001 | 1.0 | simpleParameter | TEXT | ||||||||
Optic Vessel (EMAP:1293) MP terms IMPC_HEL_011_001 | 1.0 | ontologyParameter | [MP:0006292] Absent optic vesicle [MP:0003425] Abnormal optic vesicle formation | TEXT | |||||||
Optic Vessel (EMAP:1293) process terms IMPC_HEL_012_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Optic Vessel (EMAP:1293) Severity Score IMPC_HEL_013_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Optic Vessel (EMAP:1293) Desciptor Pato IMPC_HEL_014_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Optic Vessel (EMAP:1293) Desciption IMPC_HEL_015_001 | 1.0 | simpleParameter | TEXT | ||||||||
Midbrain (EMAP:2315) MP terms IMPC_HEL_016_001 | 1.0 | ontologyParameter | [MP:0000897] abnormal midbrain morphology [MP:0004203] abnormal cranial flexure morphology | TEXT | |||||||
Midbrain (EMAP:2315) process terms IMPC_HEL_017_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Midbrain (EMAP:2315) Severity score IMPC_HEL_018_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Midbrain (EMAP:2315) Descriptor PATO IMPC_HEL_019_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Midbrain (EMAP:2315) Description IMPC_HEL_020_001 | 1.0 | simpleParameter | TEXT | ||||||||
Hindbrain (EMAP:2257) MP terms IMPC_HEL_021_001 | 1.0 | ontologyParameter | [MP:0000841] abnormal hindbrain morphology [MP:0012262] abnormal hindbrain size | TEXT | |||||||
Hindbrain (EMAP:2257) process terms IMPC_HEL_022_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Hindbrain (EMAP:2257) Severity score IMPC_HEL_023_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Hindbrain (EMAP:2257) Descriptor PATO IMPC_HEL_024_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Hindbrain (EMAP:2257) Description IMPC_HEL_025_001 | 1.0 | simpleParameter | TEXT | ||||||||
Neural tube (EMAP:1259) MP terms IMPC_HEL_026_001 | 1.0 | ontologyParameter | [MP:0002151] abnormal neural tube morphology/development [MP:0003720] abnormal neural tube closure [MP:0000930] wavy neural tube | TEXT | |||||||
Neural tube (EMAP:1259) process terms IMPC_HEL_027_001 | 1.1 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Neural tube (EMAP:1259) Severity score IMPC_HEL_028_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Neural tube (EMAP:1259) Descriptor PATO IMPC_HEL_029_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Neural tube (EMAP:1259) Description IMPC_HEL_030_001 | 1.0 | simpleParameter | TEXT | ||||||||
Notochord (EMAP:1195) MP terms IMPC_HEL_031_001 | 1.0 | ontologyParameter | [MP:0002825] abnormal notochord morphology [MP:0000932] absent notochord | TEXT | |||||||
Notochord (EMAP:1195) process terms IMPC_HEL_032_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Notochord (EMAP:1195) Severity score IMPC_HEL_033_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Notochord (EMAP:1195) Descriptor PATO IMPC_HEL_034_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Notochord (EMAP:1195) Description IMPC_HEL_035_001 | 1.0 | simpleParameter | TEXT | ||||||||
Branchial arch 1 (EMAP:1003) MP terms IMPC_HEL_036_001 | 1.0 | ontologyParameter | [MP:0006337] abnormal first branchial arch morphology [MP:0006342] absent first branchial arch | TEXT | |||||||
Branchial arch 1 (EMAP:1003) process terms IMPC_HEL_037_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Branchial arch 1 (EMAP:1003) Severity score IMPC_HEL_038_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Branchial arch 1 (EMAP:1003) Descriptor PATO IMPC_HEL_039_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Branchial arch 1 (EMAP:1003) Description IMPC_HEL_040_001 | 1.0 | simpleParameter | TEXT | ||||||||
Mandibular component (EMAP:1011) MP terms IMPC_HEL_041_001 | 1.0 | ontologyParameter | [MP:0010939] abnormal mandibular prominence morphology | TEXT | |||||||
Mandibular component (EMAP:1011) process terms IMPC_HEL_042_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Mandibular component (EMAP:1011) Severity score IMPC_HEL_043_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Mandibular component (EMAP:1011) Descriptor PATO IMPC_HEL_044_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Mandibular component (EMAP:1011) Description IMPC_HEL_045_001 | 1.0 | simpleParameter | TEXT | ||||||||
Maxillary component (EMAP:1017) MP terms IMPC_HEL_046_001 | 1.0 | ontologyParameter | [MP:0010940] abnormal maxillary prominence morphology | TEXT | |||||||
Maxillary component (EMAP:1017) process terms IMPC_HEL_047_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Maxillary component (EMAP:1017) Severity score IMPC_HEL_048_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Maxillary component (EMAP:1017) Descriptor PATO IMPC_HEL_049_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Maxillary component (EMAP:1017) Description IMPC_HEL_050_001 | 1.0 | simpleParameter | TEXT | ||||||||
Branchial arch 2 (EMAP:1025) MP terms IMPC_HEL_051_001 | 1.0 | ontologyParameter | [MP:0006338] abnormal second branchial arch morphology [MP:0006345] absent second branchial arch | TEXT | |||||||
Branchial arch 2 (EMAP:1025) process terms IMPC_HEL_052_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Branchial arch 2 (EMAP:1025) Severity score IMPC_HEL_053_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Branchial arch 2 (EMAP:1025) Descriptor PATO IMPC_HEL_054_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Branchial arch 2 (EMAP:1025) Descripttion IMPC_HEL_055_001 | 1.0 | simpleParameter | TEXT | ||||||||
Branchial arch 3 (EMAP:1038) MP terms IMPC_HEL_056_001 | 1.0 | ontologyParameter | [MP:0006339] abnormal third branchial arch morphology [MP:0010642] absent third branchial arch | TEXT | |||||||
Branchial arch 3 (EMAP:1038) process terms IMPC_HEL_057_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Branchial arch 3 (EMAP:1038) Severity score IMPC_HEL_058_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Branchial arch 3 (EMAP:1038) Descriptor PATO IMPC_HEL_059_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Branchial arch 3 (EMAP:1038) Description IMPC_HEL_060_001 | 1.0 | simpleParameter | TEXT | ||||||||
Otocyst (EMAP:1282) MP terms IMPC_HEL_061_001 | 1.0 | ontologyParameter | [MP:0009806] abnormal otic vesicle morphology [MP:0004309] absent otic vesicle [MP:0010906] abnormal lung bud morphology | TEXT | |||||||
Otocyst (EMAP:1282) process terms IMPC_HEL_062_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Otocyst (EMAP:1282) Severity score IMPC_HEL_063_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Otocyst (EMAP:1282) Descriptor PATO IMPC_HEL_064_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Otocyst (EMAP:1282) Description IMPC_HEL_065_001 | 1.0 | simpleParameter | TEXT | ||||||||
Midgut (EMAP:1407) MP terms IMPC_HEL_066_001 | 1.0 | ontologyParameter | [MP:0009705] abnormal midgut morphology [MP:0009706] absent midgut | TEXT | |||||||
Midgut (EMAP:1407) process terms IMPC_HEL_067_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Midgut (EMAP:1407) Severity score IMPC_HEL_068_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Midgut (EMAP:1407) Desciptor PATO IMPC_HEL_069_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Midgut (EMAP:1407) Desciption IMPC_HEL_070_001 | 1.0 | simpleParameter | TEXT | ||||||||
Liver primordium (EMAP:1193) MP terms IMPC_HEL_071_001 | 1.0 | ontologyParameter | [MP:0012235] abnormal liver bud morphology [MP:0000597] delayed hepatic development | TEXT | |||||||
Liver primordium (EMAP:1193) process terms IMPC_HEL_072_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Liver primordium (EMAP:1193) Severity score IMPC_HEL_073_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Liver primordium (EMAP:1193) Descriptor PATO IMPC_HEL_074_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Liver primordium (EMAP:1193) Description IMPC_HEL_075_001 | 1.0 | simpleParameter | TEXT | ||||||||
Heart (EMAP:1317) MP terms IMPC_HEL_076_001 | 1.0 | ontologyParameter | [MP:0000267] abnormal heart development [MP:0012082] delayed heart development [MP:0009382] abnormal cardiac jelly morphology [MP:0000269] abnormal heart looping [MP:0004187] cardia bifida | TEXT | |||||||
Heart (EMAP:1317) process terms IMPC_HEL_077_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Heart (EMAP:1317) Severity score IMPC_HEL_078_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Heart (EMAP:1317) Descriptor PATO IMPC_HEL_079_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Heart (EMAP:1317) Description IMPC_HEL_080_001 | 1.0 | simpleParameter | TEXT | ||||||||
Outflow tract (EMAP:1338) MP terms IMPC_HEL_081_001 | 1.0 | ontologyParameter | [MP:0006126] abnormal outflow tract development | TEXT | |||||||
Outflow tract (EMAP:1338) process terms IMPC_HEL_082_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Outflow tract (EMAP:1338) Severity score IMPC_HEL_083_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Outflow tract (EMAP:1338) Descriptor PATO IMPC_HEL_084_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Outflow tract (EMAP:1338) Description IMPC_HEL_085_001 | 1.0 | simpleParameter | TEXT | ||||||||
Bulbus cordis (EMAP:1329) MP terms IMPC_HEL_086_001 | 1.1 | ontologyParameter | [MP:0010568] abnormal bulbus cordis morphology | TEXT | |||||||
Bulbus cordis (EMAP:1329) process terms IMPC_HEL_087_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Bulbus cordis (EMAP:1329) Severity score IMPC_HEL_088_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Bulbus cordis (EMAP:1329) Descriptor PATO IMPC_HEL_089_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Bulbus cordis (EMAP:1329) Description IMPC_HEL_090_001 | 1.1 | simpleParameter | TEXT | ||||||||
Common atrial chamber (EMAP:1323) MP terms IMPC_HEL_091_001 | 1.0 | ontologyParameter | [MP:0003105] abnormal heart atrium morphology [MP:0010492] abnormal atrium endocardium morphology [MP:0010581] abnormal atrium myocardial trabeculae morphology | TEXT | |||||||
Common atrial chamber (EMAP:1323) process terms IMPC_HEL_092_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Common atrial chamber (EMAP:1323) Severity score IMPC_HEL_093_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Common atrial chamber (EMAP:1323) Descriptor PATO IMPC_HEL_094_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Common atrial chamber (EMAP:1323) Description IMPC_HEL_095_001 | 1.0 | simpleParameter | TEXT | ||||||||
Primitive ventricle (EMAP:1345) MP terms IMPC_HEL_096_001 | 1.0 | ontologyParameter | [MP:0005294] abnormal heart ventricle morphology [MP:0004067] abnormal trabecula carnea morphology [MP:0010494] abnormal ventricle endocardium morphology | TEXT | |||||||
Primitive ventricle (EMAP:1345) process terms IMPC_HEL_097_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Primitive ventricle (EMAP:1345) Severity score IMPC_HEL_098_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Primitive ventricle (EMAP:1345) Descriptor PATO IMPC_HEL_099_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Primitive ventricle (EMAP:1345) Description IMPC_HEL_100_001 | 1.0 | simpleParameter | TEXT | ||||||||
Sinus venosus (EMAP:1346) MP terms IMPC_HEL_101_001 | 1.0 | ontologyParameter | [MP:0003228] abnormal sinus venosus morphology [MP:0010562] absent sinus venosus | TEXT | |||||||
Sinus venosus (EMAP:1346) process terms IMPC_HEL_102_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Sinus venosus (EMAP:1346) Severity score IMPC_HEL_103_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Sinus venosus (EMAP:1346) Descriptor PATO IMPC_HEL_104_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Sinus venosus (EMAP:1346) Description IMPC_HEL_105_001 | 1.0 | simpleParameter | TEXT | ||||||||
Common dorsal aorta (EMAP:1308) MP terms IMPC_HEL_106_001 | 1.0 | ontologyParameter | [MP:0004787] abnormal dorsal aorta morphology | TEXT | |||||||
Common dorsal aorta (EMAP:1308) process terms IMPC_HEL_107_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Common dorsal aorta (EMAP:1308) Severity score IMPC_HEL_108_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Common dorsal aorta (EMAP:1308) Descriptor PATO IMPC_HEL_109_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Common dorsal aorta (EMAP:1308) Description IMPC_HEL_110_001 | 1.0 | simpleParameter | TEXT | ||||||||
Pericadrial cavity (EMAP:1504) MP terms IMPC_HEL_111_001 | 1.0 | ontologyParameter | [MP:0012501] abnormal pericardial cavity morphology [MP:0005312] pericardial effusion | TEXT | |||||||
Pericadrial cavity (EMAP:1504) process terms IMPC_HEL_112_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Pericadrial cavity (EMAP:1504) Severity score IMPC_HEL_113_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Pericadrial cavity (EMAP:1504) Descriptor PATO IMPC_HEL_114_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Pericadrial cavity (EMAP:1504) Description IMPC_HEL_115_001 | 1.0 | simpleParameter | TEXT | ||||||||
Proepicardial organ MP terms IMPC_HEL_116_001 | 1.0 | ontologyParameter | TEXT | ||||||||
Proepicardial organ process terms IMPC_HEL_117_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Proepicardial organ Severity score IMPC_HEL_118_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Proepicardial organ Descriptor PATO IMPC_HEL_119_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Proepicardial organ Description IMPC_HEL_120_001 | 1.0 | simpleParameter | TEXT | ||||||||
Forelimb bud (EMP:1070) MP terms IMPC_HEL_121_001 | 1.0 | ontologyParameter | [MP:0013164] abnormal forelimb bud morphology [MP:0013165] absent forelimb buds | TEXT | |||||||
Forelimb bud (EMP:1070) process terms IMPC_HEL_122_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Forelimb bud (EMP:1070) Severity score IMPC_HEL_123_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Forelimb bud (EMP:1070) Descriptor PATO IMPC_HEL_124_001 | 1.1 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Forelimb bud (EMP:1070) Description IMPC_HEL_125_001 | 1.0 | simpleParameter | TEXT | ||||||||
Somites (EMAP:1087) MP terms IMPC_HEL_126_001 | 1.0 | ontologyParameter | [MP:0001688] abnormal somite development [MP:0001691] abnormal somite shape [MP:0005222] abnormal somite size [MP:0006386] absent somites | TEXT | |||||||
Somites (EMAP:1087) process terms IMPC_HEL_127_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Somites (EMAP:1087) Severity score IMPC_HEL_128_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Somites (EMAP:1087) Descriptor PATO IMPC_HEL_129_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Somites (EMAP:1087) Description IMPC_HEL_130_001 | 1.0 | simpleParameter | TEXT | ||||||||
Surface ectoderm (EMAP:1068) MP terms IMPC_HEL_131_001 | 1.0 | ontologyParameter | [MP:0012532] abnorrmal surface ectoderm morphology | TEXT | |||||||
Surface ectoderm (EMAP:1068) process terms IMPC_HEL_132_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Surface ectoderm (EMAP:1068) Severity score IMPC_HEL_133_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Surface ectoderm (EMAP:1068) Descriptor PATO IMPC_HEL_134_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Surface ectoderm (EMAP:1068) Description IMPC_HEL_135_001 | 1.0 | simpleParameter | TEXT | ||||||||
Yolk sac (EMAP:31066) MP terms IMPC_HEL_136_001 | 1.0 | ontologyParameter | [MP:0001718] abnormal visceral yolk sac morphology [MP:0011204] abnormal visceral yolk sac blood island morphology | TEXT | |||||||
Yolk sac (EMAP:31066) process terms IMPC_HEL_137_001 | 1.0 | ontologyParameter | [MPATH:472] dorsal/ventral axis defect [MPATH:473] developmental cystic dysplasia [MPATH:474] ectasia [MPATH:475] ductal ectasia [MPATH:478] angiogenesis defect [MPATH:479] vasculogenesis defect [MPATH:480] decidual defect [MPATH:600] branching defect [MPATH:601] developmental hypertrophy [MPATH:604] defective growth and differentiation process [MPATH:613] Pigmentation [MPATH:614] Concretion | TEXT | |||||||
Yolk sac (EMAP:31066) Severity score IMPC_HEL_138_001 | 1.0 | simpleParameter | 01234Not applicable | TEXT | |||||||
Yolk sac (EMAP:31066) Descriptor PATO IMPC_HEL_139_001 | 1.0 | ontologyParameter | [PATO:0002387] peracute [PATO:0000389] acute [PATO:0002091] subacute [PATO:0001863] chronic [PATO:0002414] chronic-active [PATO:0000627] focal [PATO:0002415] focally extensive [PATO:0001791] multi-focal [PATO:0002402] multifocal to coalescing [PATO:0002401] random [PATO:0001566] diffuse [PATO:0002403] generalized [PATO:0000634] unilateral [PATO:0000618] bilateral [PATO:0002404] segmental [PATO:0000632] symmetrical [PATO:0002417] transmural | TEXT | |||||||
Yolk sac (EMAP:31066) Description IMPC_HEL_140_001 | 1.0 | simpleParameter | TEXT |
Version | Type | Req. Upload | Req. Analysis | Annotation | Increment | Option | Ontology Options | Derived | Unit | Data Type | |
---|---|---|---|---|---|---|---|---|---|---|---|
Stain IMPC_HEL_141_001 | 1.0 | procedureMetadata | H&ECresylviolet-LFB | TEXT | |||||||
Section thickness IMPC_HEL_142_001 | 1.1 | procedureMetadata | 3456 | TEXT | |||||||
Embryo marked for staining IMPC_HEL_143_001 | 1.0 | procedureMetadata | yesno | TEXT |