Gene: Gja8

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Name
gap junction protein, alpha 8
MGI ID
MGI:99953
Synonyms
connexin 50 Cnx50 alpha 8 connexin Cx50 Lop10 Aey5 dcm
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased heart rate variability Gja8tm1b(EUCOMM)Hmgu HOM Early adult 5.03×10-07
abnormal sinus arrhythmia Gja8tm1b(EUCOMM)Hmgu HOM Early adult 2.42×10-24
cardiovascular system phenotype Gja8tm1b(EUCOMM)Hmgu HOM Early adult 4.44×10-06
abnormal retina morphology Gja8tm1b(EUCOMM)Hmgu HOM Early adult 3.09×10-14

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (3/590) N/A
Aorta 4 No  (1/590) N/A
Bone 4 No N/A
Brain 4 No  (3/590) N/A
Brainstem 4 No  (2/590) N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No N/A
Cerebellum 4 No  (3/590) N/A
Cerebral cortex 4 No  (2/590) N/A
Esophagus 4 No  (7/415) N/A
Eye 4 No  (4/4)  Wholemount images
Gall bladder 4 No N/A
Heart 4 No  (1/590) N/A
Hippocampus 4 No  (3/590) N/A
Hypothalamus 4 No  (2/590) N/A
Kidney 4 No  (20/590) N/A
Large intestine 4 No  (10/590) N/A
Liver 4 No N/A
Lower urinary tract 4 No  (1/590) N/A
Lung 4 No  (1/590) N/A
Lymph node 4 No N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No  (2/590) N/A
Oral epithelium 4 No N/A
Ovary 4 No  (1/590) N/A
Oviduct 4 No N/A
Pancreas 4 No  (5/590) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No  (1/590) N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (1/590) N/A
Prostate gland 4 No  (12/590) N/A
Skeletal muscle 4 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/590) N/A
Spinal cord 4 No  (2/590) N/A
Spleen 4 No  (2/590) N/A
Stomach 4 No  (13/590) N/A
Striatum 4 No  (3/590) N/A
Testis 4 No  (5/590)  (2/4)  Wholemount images
Thymus 4 No N/A
Thyroid gland 4 No  (16/590)  Wholemount images
Trachea 4 No  (2/590) N/A
Uterus 4 No N/A
Vascular system 4 No N/A
White adipose tissue 4 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507)  (5/5) N/A
Eye 2  (1/506)  (5/5) N/A
Foot 2  (1/506) N/A
Forebrain 2  (1/506) N/A
Forelimb 2  (1/506) N/A
Hand 2  (1/506) N/A
Head 2  (5/506)  (5/5) N/A
Heart 2  (1/506) N/A
Hindbrain 2  (6/506) N/A
Hindlimb 2  (1/506) N/A
Liver 2  (1/504) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506) N/A
Tail 2  (1/506)  (3/5) N/A
Tail somite 2  (1/506) N/A

 Associated Images

Echo: M-Mode Images
20 Images
X-ray: XRay Images Whole Body Lateral Orientation
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
8 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
Adult LacZ: LacZ Images Wholemount
3 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Gja8tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Gja8tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells