Gene: Gja8

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Name
gap junction protein, alpha 8
MGI ID
MGI:99953
Synonyms
Cnx50 connexin 50 Aey5 Cx50 Lop10 alpha 8 connexin
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased heart rate variability Gja8tm1b(EUCOMM)Hmgu HOM postnatal 3.15×10-07
abnormal retina morphology Gja8tm1b(EUCOMM)Hmgu HOM postnatal 7.04×10-14
cardiovascular system phenotype Gja8tm1b(EUCOMM)Hmgu HOM postnatal 7.72×10-06

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584) N/A
Aorta 4 No N/A
Bone 4 No N/A
Brain 4 No N/A
Brainstem 4 No N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No N/A
Cerebellum 4 No N/A
Cerebral cortex 4 No N/A
Esophagus 4 No  (7/415) N/A
Eye 4 No  (4/4)  Wholemount images
Gall bladder 4 No N/A
Heart 4 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Kidney 4 No  (18/584) N/A
Large intestine 4 No  (10/584) N/A
Liver 4 No N/A
Lower urinary tract 4 No N/A
Lung 4 No N/A
Lymph node 4 No N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No N/A
Oral epithelium 4 No N/A
Ovary 4 No  (1/584) N/A
Oviduct 4 No N/A
Pancreas 4 No  (5/584) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No N/A
Prostate gland 4 No  (12/584) N/A
Skeletal muscle 4 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No N/A
Spleen 4 No  (2/584) N/A
Stomach 4 No  (12/584) N/A
Striatum 4 No N/A
Testis 4 No  (2/584)  (2/4)  Wholemount images
Thymus 4 No N/A
Thyroid gland 4 No  (15/584)  Wholemount images
Trachea 4 No N/A
Uterus 4 No N/A
Vascular system 4 No N/A
White adipose tissue 4 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (5/5) N/A
Eye 2  (1/485)  (4/5) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (4/5) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485)  (3/5) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Lateral Orientation
8 Images
Echo: M-Mode Images
20 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
X-ray: XRay Images Dorso Ventral
8 Images
Adult LacZ: LacZ Images Wholemount
3 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - developmental dysplasia Gja8tm1b(EUCOMM)Hmgu HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Gja8tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Gja8tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice