Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased erythrocyte cell number | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 9.31×10-06 | ||
limb grasping | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 3.76×10-05 | ||
decreased startle reflex | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 1.91×10-05 | ||
decreased eosinophil cell number | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 8.16×10-05 | ||
decreased fasting circulating glucose level | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 4.64×10-06 | ||
abnormal bone structure | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 1.81×10-05 | ||
increased grip strength | Ppm1atm1b(EUCOMM)Hmgu | HOM | Early adult | 2.15×10-05 |
Gene: Ppm1a
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IMPC lacZ Expression Data
Anatomy | #HET Specimens | HOM Images? | WT Expr | Mutant Expr | Images |
---|---|---|---|---|---|
Adrenal gland | 1 | No | (3/590) | (1/1) | N/A |
Aorta | 1 | No | (1/590) | (1/1) | N/A |
Bone | 1 | No | (1/1) | N/A | |
Brain | 1 | No | (3/590) | (1/1) | N/A |
Brainstem | 1 | No | (2/590) | (1/1) | N/A |
Brown adipose tissue | 1 | No | (1/1) | N/A | |
Cartilage tissue | 1 | No | (1/1) | N/A | |
Cerebellum | 1 | No | (3/590) | (1/1) | N/A |
Cerebral cortex | 1 | No | (2/590) | (1/1) | N/A |
Esophagus | 1 | No | (7/415) | (1/1) | N/A |
Eye | 1 | No | (1/1) | N/A | |
Gall bladder | 1 | No | (1/1) | N/A | |
Heart | 1 | No | (1/590) | (1/1) | N/A |
Hippocampus | 1 | No | (3/590) | (1/1) | N/A |
Hypothalamus | 1 | No | (2/590) | (1/1) | N/A |
Kidney | 1 | No | (20/590) | (1/1) | N/A |
Large intestine | 1 | No | (10/590) | (1/1) | N/A |
Liver | 1 | No | N/A | ||
Lower urinary tract | 1 | No | (1/590) | (1/1) | Wholemount images |
Lung | 1 | No | (1/590) | (1/1) | N/A |
Lymph node | 1 | No | (1/1) | N/A | |
Mammary gland | 1 | No | N/A | ||
Olfactory lobe | 1 | No | (2/590) | (1/1) | N/A |
Oral epithelium | 1 | No | (1/1) | N/A | |
Ovary | 1 | No | (1/590) | N/A | |
Oviduct | 1 | No | N/A | ||
Pancreas | 1 | No | (5/590) | (1/1) | N/A |
Parathyroid gland | 1 | No | (1/1) | N/A | |
Peripheral nervous system | 1 | No | (1/590) | (1/1) | N/A |
Peyer's patch | 1 | No | (1/1) | Wholemount images | |
Pituitary gland | 1 | No | (1/590) | (1/1) | N/A |
Prostate gland | 1 | No | (12/590) | (1/1) | Wholemount images |
Skeletal muscle | 1 | No | (1/1) | N/A | |
Skin | 1 | No | (1/1) | N/A | |
Small intestine | 1 | No | (9/590) | (1/1) | Wholemount images |
Spinal cord | 1 | No | (2/590) | (1/1) | N/A |
Spleen | 1 | No | (2/590) | N/A | |
Stomach | 1 | No | (13/590) | (1/1) | N/A |
Striatum | 1 | No | (3/590) | (1/1) | N/A |
Testis | 1 | No | (5/590) | (1/1) | Wholemount images |
Thymus | 1 | No | (1/1) | N/A | |
Thyroid gland | 1 | No | (16/590) | (1/1) | N/A |
Trachea | 1 | No | (2/590) | (1/1) | N/A |
Uterus | 1 | No | N/A | ||
Vascular system | 1 | No | (1/1) | N/A | |
White adipose tissue | 1 | No | (1/1) | Wholemount images |
LacZ Wholemount Images
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
Testis expression
White Adipose Tissue expression
MA:0000058
MA:0000411
LacZ Section Images
Anatomy | #HET Specimens | WT Expr | Mutant Expr | Images |
---|---|---|---|---|
Brain | 2 | (6/506) | (4/4) | N/A |
Ear | 2 | (1/506) | (2/4) | N/A |
Embryo | 2 | (1/507) | (4/4) | N/A |
Eye | 2 | (1/506) | (4/4) | N/A |
Foot | 2 | (1/506) | (4/4) | N/A |
Forebrain | 2 | (1/506) | (4/4) | N/A |
Forelimb | 2 | (1/506) | (4/4) | N/A |
Hand | 2 | (1/506) | (4/4) | N/A |
Head | 2 | (5/506) | (4/4) | N/A |
Heart | 2 | (1/506) | (2/4) | N/A |
Hindbrain | 2 | (6/506) | (4/4) | N/A |
Hindlimb | 2 | (1/506) | (4/4) | N/A |
Liver | 2 | (1/504) | (1/4) | N/A |
Lung | 2 | (1/504) | (2/4) | N/A |
Mandibular process | 2 | (1/506) | (2/4) | N/A |
Maxillary process | 2 | (1/506) | (2/4) | N/A |
Midbrain | 2 | (1/506) | (4/4) | N/A |
Oral cavity | 2 | (1/504) | (2/4) | N/A |
Skin | 2 | (1/506) | N/A | |
Tail | 2 | (1/506) | (4/4) | N/A |
Tail somite | 2 | (1/506) | (2/4) | N/A |
Associated Images
Disease Models
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MGI Allele | Allele Type | Produced |
---|---|---|
Ppm1atm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (post-Cre) | Mice |
Ppm1atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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