Clock | clock circadian regulator

GeneMGI:99698Synonyms: KAT13D, bHLHe8, +1 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Skeleton Craniofacial Cardiovascular system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased red blood cell distribution width1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adult5.21x10-6 
increased T-helper cell number1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adult1.68x10-9 
increased lung elastance3 supporting datasetsClockem1(IMPC)CcpczhomozygoteEarly adult6.12x10-6 
enlarged thymus1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal inspiratory capacity1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adult7.39x10-7 
increased CD4-positive, alpha-beta T cell number1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adult5.45x10-9 
abnormal tooth morphology1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased eosinophil cell number1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adult3.1x10-7 
abnormal skin morphology2 supporting datasetsClockem1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased circulating triglyceride level1 supporting datasetClockem1(IMPC)CcpczhomozygoteEarly adult3.44x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Clockem1(IMPC)CcpczExon Deletionmouse
Clocktm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
es cell

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