Genes Phenotypes

Gene: Rasgrf1

Name
RAS protein-specific guanine nucleotide-releasing factor 1
MGI ID
MGI:99694
Synonyms
Grf1 CDC25Mm CDC25 Grfbeta
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (224) All data table (344)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Rasgrf1tm1bNarl HOM postnatal 1.42×10-06
decreased bone mineral content Rasgrf1tm1bNarl HOM postnatal 7.48×10-09
thrombocytopenia Rasgrf1tm1bNarl HOM postnatal 7.17×10-05
decreased grip strength Rasgrf1tm1bNarl HOM postnatal 4.32×10-05
abnormal behavior Rasgrf1tm1bNarl HOM postnatal 1.93×10-05
decreased circulating cholesterol level Rasgrf1tm1bNarl HOM postnatal 5.30×10-08
abnormal bone structure Rasgrf1tm1bNarl HOM postnatal 1.10×10-05
decreased lean body mass Rasgrf1tm1bNarl HOM postnatal 3.56×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
endocrine system (1)
Thyroid gland expression
MA:0000129
nervous system (3)
Hippocampus expression
Brain expression
MA:0000191
MA:0000168
postnatal mouse (5)
Hippocampus expression
Brain expression
MA:0000191
MA:0000168
reproductive system (1)
Testis expression
MA:0000411
trunk (1)
Testis expression
MA:0000411
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/485) N/A
Ear 1  (1/485) N/A
Embryo 1  (1/485) N/A
Eye 1  (1/485) N/A
Foot 1  (1/485) N/A
Forebrain 1  (1/485) N/A
Forelimb 1  (1/485) N/A
Hand 1  (1/485) N/A
Head 1  (5/485) N/A
Heart 1  (1/485) N/A
Hindbrain 1  (6/485) N/A
Hindlimb 1  (1/485) N/A
Liver 1  (1/485) N/A
Lung 1  (1/485) N/A
Mandibular process 1  (1/485) N/A
Maxillary process 1  (1/485) N/A
Midbrain 1  (1/485) N/A
Oral cavity 1  (1/485) N/A
Skin 1  (1/485) N/A
Tail 1  (1/485) N/A
Tail somite 1  (1/485) N/A

 Associated Images

Echo: M-Mode Images
28 Images
Adult LacZ: LacZ Images Wholemount
5 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Rasgrf1tm1bNarl Reporter-tagged deletion allele (post-Cre) Mice
Rasgrf1tm1aNarl KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors

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