Genes Phenotypes

Gene: Rasgrf1

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Name
RAS protein-specific guanine nucleotide-releasing factor 1
MGI ID
MGI:99694
Synonyms
Grf1 Grfbeta CDC25 CDC25Mm
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (216) All data table (373)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone structure Rasgrf1tm1bNarl HOM Early adult 1.71×10-07
decreased circulating cholesterol level Rasgrf1tm1bNarl HOM Early adult 1.10×10-08
decreased bone mineral content Rasgrf1tm1bNarl HOM Early adult 9.61×10-13
decreased bone mineral density Rasgrf1tm1bNarl HOM Early adult 7.15×10-09
decreased lean body mass Rasgrf1tm1bNarl HOM Early adult 5.36×10-08
thrombocytopenia Rasgrf1tm1bNarl HOM Early adult 5.32×10-05
decreased total body fat amount Rasgrf1tm1bNarl HOM Early adult 3.47×10-05
decreased grip strength Rasgrf1tm1bNarl HOM Early adult 4.19×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
endocrine system (1)
Thyroid gland expression
MA:0000129
nervous system (3)
Hippocampus expression
Brain expression
Brainstem expression
MA:0000191
MA:0000168
MA:0000169
postnatal mouse (5)
Hippocampus expression
Brain expression
Brainstem expression
MA:0000191
MA:0000168
MA:0000169
reproductive system (1)
Testis expression
MA:0000411
trunk (1)
Testis expression
MA:0000411
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/504) N/A
Ear 1  (1/504) N/A
Embryo 1  (1/505) N/A
Eye 1  (1/504) N/A
Foot 1  (1/504) N/A
Forebrain 1  (1/504) N/A
Forelimb 1  (1/504) N/A
Hand 1  (1/503) N/A
Head 1  (5/504) N/A
Heart 1  (1/504) N/A
Hindbrain 1  (6/504) N/A
Hindlimb 1  (1/503) N/A
Liver 1  (1/504) N/A
Lung 1  (1/500) N/A
Mandibular process 1  (1/504) N/A
Maxillary process 1  (1/504) N/A
Midbrain 1  (1/504) N/A
Oral cavity 1  (1/504) N/A
Skin 1  (1/504) N/A
Tail 1  (1/504) N/A
Tail somite 1  (1/504) N/A

 Associated Images

Echo: M-Mode Images
28 Images
Adult LacZ: LacZ Images Wholemount
5 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rasgrf1tm1aNarl KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors
Rasgrf1tm1bNarl Reporter-tagged deletion allele (post-Cre) Mice

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