Gene: Rasgrf1

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Name
RAS protein-specific guanine nucleotide-releasing factor 1
MGI ID
MGI:99694
Synonyms
CDC25Mm CDC25 Grfbeta Grf1
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased anxiety-related response Rasgrf1tm1bNarl HOM Early adult 1.84×10-10
increased thigmotaxis Rasgrf1tm1bNarl HOM Early adult 1.26×10-07
decreased total body fat amount Rasgrf1tm1bNarl HOM Early adult 3.12×10-05
decreased grip strength Rasgrf1tm1bNarl HOM Early adult 6.31×10-05
thrombocytopenia Rasgrf1tm1bNarl HOM   Early adult 8.50×10-06
abnormal behavior Rasgrf1tm1bNarl HOM Early adult 1.26×10-07
decreased circulating cholesterol level Rasgrf1tm1bNarl HOM Early adult 1.75×10-07
hypoactivity Rasgrf1tm1bNarl HOM Early adult 4.89×10-05
increased lean body mass Rasgrf1tm1bNarl HOM Early adult 7.18×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583) N/A
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Esophagus 2 No  (7/407) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/583) N/A
Hippocampus 2 No  (3/583)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583) N/A
Large intestine 2 No  (10/583) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/583) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563) N/A
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583) N/A
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583) N/A
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583)  (1/2)  Wholemount images
Trachea 2 No  (3/583) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
1  (6/505) N/A
1  (1/505) N/A
1  (1/506) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (5/505) N/A
1  (1/505) N/A
1  (6/505) N/A
1  (1/505) N/A
1  (1/503) N/A
1  (1/503) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/503) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A

 Associated Images

Echo: M-Mode Images
28 Images
Adult LacZ: LacZ Images Wholemount
5 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rasgrf1tm1bNarl Reporter-tagged deletion allele (post-Cre) Mice
Rasgrf1tm1aNarl KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors

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