Gene: Pola2

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Pola2tm1b(KOMP)Mbp HOM   E9.5 0.00
preweaning lethality, complete penetrance Pola2tm1b(KOMP)Mbp HOM   Early adult 0.00
embryonic lethality prior to tooth bud stage Pola2tm1b(KOMP)Mbp HOM   E12.5 0.00
increased mean corpuscular volume Pola2tm1b(KOMP)Mbp HET Early adult 7.09×10-05

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583) N/A
Brain 2 No  (4/583) N/A
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Epididymis 2 No  (18/132) N/A
Esophagus 2 No  (7/407) N/A
Eye 2 No N/A
Heart 2 No  (2/583) N/A
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583)  (2/2)  Section images
Large intestine 2 No  (10/583)  (2/2)  Section images
Liver 2 No N/A
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No  (2/583) N/A
Ovary 2 No  (1/583)  (1/2)  Section images
Oviduct 2 No N/A
Pancreas 2 No  (5/583) N/A
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583)  (2/2)  Section images
Spinal cord 2 No  (3/583)  Section images
Spleen 2 No  (3/583)  (2/2)  Section images
Stomach 2 No  (13/583) N/A
Striatum 2 No  (3/583) N/A
Submandibular gland 2 No  (2/130) N/A
Testis 2 No  (6/583)  (1/2)  Section images
Thalamus 2 No N/A
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583) N/A
Urinary bladder 2 No N/A
Uterus 2 No  Section images
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/2) N/A
2  (1/60) Image Only N/A
2  (1/505)  (2/2) N/A
2  (1/506)  (2/2)  Wholemount images
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/61) Image Only N/A
2  (1/505)  (2/2) N/A
2  (5/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (6/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/503)  (2/2) N/A
2  (1/503) Image Only N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/75)  (2/2) N/A
2  (1/503) Image Only N/A
2  (1/505)  (2/2) N/A
2  (1/72)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
11 Images
Sleep Wake: Wake state (bmp file)
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
Original Image
Adult LacZ: LacZ Images Section
9 Images
Eye Morphology: Images Ophthalmoscopy
8 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
7 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pola2tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Pola2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Pola2tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice

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