Gene: Ryr1

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Name
ryanodine receptor 1, skeletal muscle
MGI ID
MGI:99659
Synonyms
calcium release channel isoform 1 Ryr skrr
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased respiratory quotient Ryr1tm1b(EUCOMM)Hmgu HET   Early adult 1.14×10-05
increased spleen weight Ryr1tm1b(EUCOMM)Hmgu HET Early adult 1.53×10-12
preweaning lethality, complete penetrance Ryr1tm1b(EUCOMM)Hmgu HOM   Early adult 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584)  (1/2)  Wholemount images
Aorta 2 No  (1/584) N/A
Bone 2 No N/A
Brain 2 No  (4/584)  (1/2)  Wholemount images
Brainstem 2 No  (2/584) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584) N/A
Cerebellum 2 No  (3/584) N/A
Cerebral cortex 2 No  (2/584) N/A
Esophagus 2 No  (7/408) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/584) N/A
Hippocampus 2 No  (3/584) N/A
Hypothalamus 2 No  (2/584) N/A
Kidney 2 No  (21/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/584) N/A
Lung 2 No  (2/584) N/A
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/584) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/562)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/584) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/584) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (3/584) N/A
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584)  (1/2)  Wholemount images
Striatum 2 No  (3/584) N/A
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584) N/A
Thyroid gland 2 No  (16/584)  (2/2)  Wholemount images
Trachea 2 No  (3/584) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/507) N/A
Ear 2  (1/507) N/A
Embryo 2  (1/508)  (4/4) N/A
Eye 2  (1/507) N/A
Footplate 2  (1/507) N/A
Forebrain 2  (1/507) N/A
Forelimb 2  (1/507)  (3/4) N/A
Handplate 2  (1/507) N/A
Head 2  (5/507)  (2/4) N/A
Heart 2  (1/507) N/A
Hindbrain 2  (6/507) N/A
Hindlimb 2  (1/507)  (2/4) N/A
Liver 2  (1/502) N/A
Lung 2  (1/502) N/A
Mandibular process 2  (1/507) N/A
Maxillary process 2  (1/507) N/A
Midbrain 2  (1/507) N/A
Oral cavity 2  (1/502) N/A
Skin 2  (1/507) N/A
Tail 2  (1/507)  (4/4) N/A
Tail somite group 2  (1/507)  (1/4) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
7 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

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MGI Allele Allele Type Produced
Ryr1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ryr1tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Ryr1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice