Genes Phenotypes

Gene: Abca1

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Name
ATP-binding cassette, sub-family A (ABC1), member 1
MGI ID
MGI:99607
Synonyms
ABC1
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (234) All data table (821)
Expression & images (111) Disease models (0) Histopathology (2) Order (6)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal locomotor behavior Abca1tm1b(EUCOMM)Hmgu HET Early adult 5.28×10-05
preweaning lethality, complete penetrance Abca1tm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal embryo size Abca1tm1b(EUCOMM)Hmgu HOM E18.5 0.00
abnormal embryo size Abca1tm1b(EUCOMM)Hmgu HET E18.5 0.00
abnormal retina morphology Abca1tm1b(EUCOMM)Hmgu HET Early adult 2.50×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No  (3/589)  (2/3)  Wholemount images
Aorta 3 No  (1/589)  (3/3)  Wholemount images
Bone 3 No  (3/3)  Wholemount images
Brain 3 No  (3/589)  (3/3)  Wholemount images
Brainstem 3 No  (2/589)  (3/3)  Wholemount images
Brown adipose tissue 3 No  (3/3)  Wholemount images
Cartilage tissue 3 No  (3/3)  Wholemount images
Cecum 3 No  (12/379) N/A
Cerebellum 3 No  (3/589)  (3/3)  Wholemount images
Cerebral cortex 3 No  (2/589)  (3/3)  Wholemount images
Esophagus 3 No  (7/415) N/A
Eye 3 No N/A
Gall bladder 3 No  (3/3)  Wholemount images
Heart 3 No  (1/589)  (3/3)  Wholemount images
Hippocampus 3 No  (3/589)  (3/3)  Wholemount images
Hypothalamus 3 No  (2/589)  (3/3)  Wholemount images
Kidney 3 No  (20/589)  (3/3)  Wholemount images
Large intestine 3 No  (10/589) N/A
Liver 3 No  (3/3)  Wholemount images
Lower urinary tract 3 No  (1/589)  (3/3)  Wholemount images
Lung 3 No  (1/589)  (3/3) N/A
Lymph node 3 No  (3/3) N/A
Mammary gland 3 No N/A
Olfactory lobe 3 No  (2/589)  (3/3)  Wholemount images
Oral epithelium 3 No  (3/3)  Wholemount images
Ovary 3 No  (1/589)  (1/3)  Wholemount images
Oviduct 3 No  (1/3)  Wholemount images
Pancreas 3 No  (5/589)  (3/3)  Wholemount images
Parathyroid gland 3 No N/A
Peripheral nervous system 3 No  (1/589)  (3/3)  Wholemount images
Peyer's patch 3 No N/A
Pituitary gland 3 No  (1/589)  (3/3)  Wholemount images
Prostate gland 3 No  (12/589)  (2/3)  Wholemount images
Skeletal muscle 3 No  (3/3)  Wholemount images
Skin 3 No  (3/3)  Wholemount images
Small intestine 3 No  (9/589) N/A
Spinal cord 3 No  (2/589)  (3/3)  Wholemount images
Spleen 3 No  (2/589) N/A
Stomach 3 No  (13/589)  (3/3)  Wholemount images
Striatum 3 No  (3/589)  (3/3)  Wholemount images
Testis 3 No  (5/589)  (2/3)  Wholemount images
Thymus 3 No N/A
Thyroid gland 3 No  (16/589)  (3/3)  Wholemount images
Trachea 3 No  (2/589)  (3/3)  Wholemount images
Trigeminal V nerve 3 No  (3/3)  Wholemount images
Uterus 3 No  (1/3)  Wholemount images
Vas deferens 3 No  (15/388)  (1/3)  Wholemount images
Vascular system 3 No N/A
White adipose tissue 3 No  (3/3)  Wholemount images
LacZ Wholemount Images
Unassigned Top Level MA (58)
adipose tissue (2)
Brown adipose tissue expression
MA:0000057
digestive system (4)
Liver expression
MA:0000358
endocrine system (1)
Adrenal gland expression
MA:0000116
immune system (4)
Mesenteric Lymph Node
MA:0002829
integumental system (2)
Skin expression
MA:0000151
nervous system (2)
Spinal cord expression
MA:0000216
postnatal mouse (19)
Adrenal gland expression
MA:0000116
respiratory system (2)
Oral epithelium expression
MA:0000344
set of connective tissues (2)
Brown adipose tissue expression
MA:0000057
trunk (10)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/61) N/A
Axial skeleton 2  (1/65) N/A
Brain 2  (6/506)  (2/3) N/A
Central nervous system ganglion 2  (1/74)  (1/3) N/A
Cranium 2  (1/65) N/A
Dorsal root ganglion 2  (1/61) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507)  (2/3) N/A
Outer ear 2  (1/70) N/A
Eye 2  (1/506) N/A
Femur pre-cartilage condensation 2  (1/56)  (2/3) N/A
Foot 2  (1/506)  (2/3) N/A
Forearm 2  (1/301) N/A
Forebrain 2  (1/506)  (2/3) N/A
Forelimb 2  (1/506)  (2/3) N/A
Fronto-nasal process 2  (1/62)  (2/3) N/A
Gut 2  (1/60) N/A
Hand 2  (1/505)  (2/3) N/A
Head 2  (5/506)  (2/3) N/A
Head mesenchyme 2  (1/61)  (2/3) N/A
Heart 2  (1/506) N/A
Heart ventricle 2  (1/61) N/A
Hindbrain 2  (6/506)  (2/3) N/A
Hindlimb 2  (1/505)  (2/3) N/A
Humerus pre-cartilage condensation 2  (1/65) N/A
Inner ear 2  (1/65) N/A
Intestine 2  (1/59) N/A
Liver 2  (1/506)  (2/3) N/A
Lower leg 2  (1/301) N/A
Lung 2  (1/502) N/A
Mandibular process 2  (1/506)  (1/3) N/A
Maxillary process 2  (1/506) N/A
Mesonephros of female 2  (1/56) N/A
Mesonephros of male 2  (1/56) N/A
Metanephros 2  (1/56) N/A
Midbrain 2  (1/506)  (2/3) N/A
Nasal septum 2  (1/61) N/A
Nose 2  (1/74) N/A
Notochord 2  (1/61) N/A
Oral cavity 2  (1/506)  (2/3) N/A
Outflow tract 2  (1/61) N/A
Pancreas 2  (1/56) N/A
Pericardium 2  (1/56)  (2/3) N/A
Pharynx 2  (1/56) N/A
Radius-ulna pre-cartilage condensation 2  (1/65)  (2/3) N/A
Rib pre-cartilage condensation 2  (1/58)  (2/3) N/A
Skeleton 2  (1/74) N/A
Skin 2  (1/506) N/A
Spinal cord 2  (1/73)  (2/3) N/A
Stomach 2  (1/56)  (2/3) N/A
Tail 2  (1/506)  (2/3) N/A
Tail somite 2  (1/506)  (2/3) N/A
Thoracic vertebral cartilage condensation 2  (1/56)  (2/3) N/A
Tongue 2  (1/56)  (2/3) N/A
Trachea 2  (1/60) N/A
Trunk mesenchyme 2  (1/61)  (2/3) N/A
Umbilical artery embryonic part 2  (1/61) N/A
Umbilical vein embryonic part 2  (1/61) N/A
Upper arm 2  (1/301) N/A
Upper leg 2  (1/301) N/A
Urinary system 2  (1/60) N/A
Vibrissa 2  (1/70) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
77 Images
X-ray: XRay Images Skull Lateral Orientation
9 Images
X-ray: XRay Images Forepaw
9 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images
Immunophenotyping: Panel B FCS file(s)
6 Images
X-ray: XRay Images Whole Body Dorso Ventral
9 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
MicroCT E18.5: Embryo reconstruction
1 Images
Immunophenotyping: Panel A FCS file(s)
6 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - developmental and structural abnormality Abca1tm1b(EUCOMM)Hmgu HET Early adult
Eye with optic nerve - hypoplasia Abca1tm1b(EUCOMM)Hmgu HET Early adult

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MGI Allele Allele Type Produced
Abca1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Abca1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Abca1tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Abca1tm398(L1L2_Bact_P) Targeting vectors
Abca1tm398(L1L2_gt0) Targeting vectors
Abca1tm398(L1L2_st0) Targeting vectors