Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
phosphodiesterase 4D, cAMP specific
Synonyms:
dunce,  Dpde3,  9630011N22Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Pde4d mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Pde4d by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pde4D Haploinsufficiency Syndrome
Intrauterine growth retardation, Postnatal growth retardation, Obesity ORPHA:439822
Acrodysostosis
Irregular menstruation, Hypogonadism, Short stature ORPHA:950
Acrodysostosis 2 With Or Without Hormone Resistance
Intrauterine growth retardation, Mild short stature, Obesity OMIM:614613
Acrodysostosis With Multiple Hormone Resistance
Intrauterine growth retardation, Hypogonadism, Mild short stature, Obesity ORPHA:280651

The table below shows human diseases predicted to be associated to Pde4d by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Specific Granule Deficiency 1
Absent neutrophil specific granules, Increased neutrophil mitochondria, Increased neutrophil ribo... OMIM:245480
Immunodeficiency 81
Decreased proportion of class-switched memory B cells, Autoimmune hemolytic anemia, Reduced natur... OMIM:619374
Neutrophil Immunodeficiency Syndrome
Leukocytosis, Abnormality of neutrophil physiology ORPHA:183707
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Leukocytosis, Impaired oxidative burst, Abnormally low T cell receptor excision circle level, Imp... OMIM:608203
Granulomatous disease with defect in neutrophil chemotaxis
Impaired neutrophil killing of staphylococci OMIM:233670
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine, T l... OMIM:618986
Shwachman-Diamond Syndrome
Growth delay, Hypoamylasemia, Chronic neutropenia, Neutropenia, Impaired neutrophil chemotaxis, N... ORPHA:811
Congenital Disorder Of Glycosylation, Type Iic
Neutrophilia, Reduction of neutrophil motility, Short stature OMIM:266265
Say-Barber-Miller Syndrome
Decreased circulating antibody level, Impaired neutrophil chemotaxis, Abnormal T cell morphology,... ORPHA:3132
Necrobiosis Lipoidica
Abnormality of neutrophil physiology, Granuloma ORPHA:542592
Mast Cell Sarcoma
Mastocytosis, Weight loss, Splenomegaly ORPHA:66661
Leukocyte Adhesion Deficiency
Impaired platelet aggregation, Thrombocytosis, Leukocytosis, Polycythemia, Growth delay, Impaired... ORPHA:2968
Indolent Systemic Mastocytosis
Increased proportion of CD25+ mast cells, Abnormal mast cell morphology, Mastocytosis, Splenomegaly ORPHA:98848
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Hemolytic anemia, Lymphopenia, Impaired oxidative burst, Granuloma, Perianal abscess, Short statu... OMIM:618935
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Nonspherocytic hemolytic anemia, Impaired neutrophil bactericidal activity, Spontaneous hemolytic... OMIM:613470
Chediak-Higashi Syndrome
Hemophagocytosis, Abnormal dense granules, Impaired neutrophil bactericidal activity, Neutropenia... OMIM:214500
Ch├ędiak-Higashi Syndrome
Increased proportion of CD25+ mast cells, Hemophagocytosis, Increased circulating ferritin concen... ORPHA:167
Aggressive Systemic Mastocytosis
Increased proportion of CD25+ mast cells, Leukocytosis, Neutropenia, Weight loss, Pancytopenia, T... ORPHA:98850
Systemic Mastocytosis With Associated Hematologic Neoplasm
Myeloid leukemia, Leukocytosis, Chronic lymphatic leukemia, Weight loss, Normocytic anemia, Throm... ORPHA:98849
Dyskeratosis Congenita, Autosomal Recessive 5
Decreased circulating antibody level, Postnatal growth retardation, Leukopenia, Intrauterine grow... OMIM:615190
Focal Facial Dermal Dysplasia Type Iv
Abnormal mast cell morphology ORPHA:398189
X-Linked Lymphoproliferative Disease
Increased circulating ferritin concentration, Lymphocytosis, Pancytopenia, Histiocytosis, Increas... ORPHA:2442
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Impaired oxidative burst, Rectal abscess, Splenomegaly, Liver abscess, Granulomatosis OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Impaired oxidative burst, Rectal abscess, Splenomegaly, Liver abscess, Granulomatosis OMIM:233710
Granulomatous Disease, Chronic, X-Linked
Impaired oxidative burst, Rectal abscess, Splenomegaly, Liver abscess, Granulomatosis OMIM:306400
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Impaired oxidative burst, Rectal abscess, Splenomegaly, Liver abscess, Granulomatosis OMIM:233690
Pmm2-Cdg
Impaired neutrophil chemotaxis, Hypoalbuminemia, Failure to thrive, Reduced thyroxin-binding glob... ORPHA:79318
Hennekam-Beemer Syndrome
Mastocytosis, Failure to thrive, Short stature ORPHA:2135
Mastocytosis
Acute leukemia, Chronic leukemia, Mastocytosis, Splenomegaly ORPHA:98292
Pde4D Haploinsufficiency Syndrome
Intrauterine growth retardation, Postnatal growth retardation, Obesity ORPHA:439822
Acrodysostosis
Irregular menstruation, Hypogonadism, Short stature ORPHA:950
Acrodysostosis 2 With Or Without Hormone Resistance
Intrauterine growth retardation, Mild short stature, Obesity OMIM:614613
Acrodysostosis With Multiple Hormone Resistance
Intrauterine growth retardation, Hypogonadism, Mild short stature, Obesity ORPHA:280651

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pde4d

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pde4d.

No publications found that use IMPC mice or data for Pde4d.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pde4dtm378682(L1L2_Bact_P) Targeting vectors
Pde4dtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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