Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
phosphodiesterase 4D, cAMP specific
Synonyms:
9630011N22Rik,  Dpde3,  dunce

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Pde4d mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Pde4d by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pde4D Haploinsufficiency Syndrome
Postnatal growth retardation, Obesity, Intrauterine growth retardation ORPHA:439822
Acrodysostosis
Short stature, Irregular menstruation, Hypogonadism ORPHA:950
Acrodysostosis 2 With Or Without Hormone Resistance
Obesity, Intrauterine growth retardation, Mild short stature OMIM:614613
Acrodysostosis With Multiple Hormone Resistance
Mild short stature, Obesity, Intrauterine growth retardation, Hypogonadism ORPHA:280651

The table below shows human diseases predicted to be associated to Pde4d by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Specific Granule Deficiency 1
Increased neutrophil ribosomes, Increased neutrophil mitochondria, Impaired neutrophil bactericid... OMIM:245480
Immunodeficiency 81
Reduced antigen-specific T cell proliferation, Impaired neutrophil chemotaxis, Reduced natural ki... OMIM:619374
Neutrophil Immunodeficiency Syndrome
Leukocytosis, Abnormality of neutrophil physiology ORPHA:183707
Immunodeficiency 86
Decreased circulating IgG level, Impaired oxidative burst, Increased circulating IgM level OMIM:619549
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Reduction of neutrophil motility, Leukocytosis, Impaired neutrophil chemotaxis, Rectal abscess, N... OMIM:608203
Granulomatous disease with defect in neutrophil chemotaxis
Impaired neutrophil killing of staphylococci OMIM:233670
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Pancytopenia, Decreased circulating IgG level, T lymphocytopenia, Leukopenia, Partial absence of ... OMIM:618986
Congenital Disorder Of Glycosylation, Type Iic
Reduction of neutrophil motility, Short stature, Neutrophilia OMIM:266265
Shwachman-Diamond Syndrome
Pancytopenia, Leukopenia, Normocytic anemia, Leukemia, Bone marrow hypocellularity, Impaired neut... ORPHA:811
Say-Barber-Miller Syndrome
Decreased circulating IgG level, Transient hypogammaglobulinemia of infancy, Impaired neutrophil ... ORPHA:3132
Necrobiosis Lipoidica
Granuloma, Abnormality of neutrophil physiology ORPHA:542592
Mast Cell Sarcoma
Mastocytosis, Splenomegaly, Weight loss ORPHA:66661
Leukocyte Adhesion Deficiency
Leukocytosis, Intrauterine growth retardation, Impaired platelet aggregation, Bone marrow hypocel... ORPHA:2968
Indolent Systemic Mastocytosis
Abnormal mast cell morphology, Mastocytosis, Increased proportion of CD25+ mast cells, Splenomegaly ORPHA:98848
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Impaired neutrophil bactericidal activity, Nonspherocytic hemolytic anemia, Splenomegaly, Spontan... OMIM:613470
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Hepatosplenomegaly, Splenomegaly, Abscess, Short stature, Granuloma, Hemolytic anemia, Perianal a... OMIM:618935
Aggressive Systemic Mastocytosis
Pancytopenia, Abnormal mast cell morphology, Hepatosplenomegaly, Leukemia, Leukocytosis, Increase... ORPHA:98850
Chediak-Higashi Syndrome
Leukopenia, Giant neutrophil granules, Hemophagocytosis, Splenomegaly, Neutropenia, Anemia, Impai... OMIM:214500
Ch├ędiak-Higashi Syndrome
Pancytopenia, Increased circulating ferritin concentration, Hypoproteinemia, Abnormal platelet fu... ORPHA:167
Systemic Mastocytosis With Associated Hematologic Neoplasm
Eosinophilia, Abnormal mast cell morphology, Leukocytosis, Normocytic anemia, Chronic myelomonocy... ORPHA:98849
Focal Facial Dermal Dysplasia Type Iv
Abnormal mast cell morphology ORPHA:398189
Dyskeratosis Congenita, Autosomal Recessive 5
Leukopenia, Bone marrow hypocellularity, Intrauterine growth retardation, Decreased circulating a... OMIM:615190
X-Linked Lymphoproliferative Disease
Pancytopenia, Decreased circulating IgG level, Histiocytosis, Absent natural killer cells, Increa... ORPHA:2442
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Rectal abscess, Splenomegaly, Granulomatosis, Liver abscess, Impaired oxidative burst OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Rectal abscess, Splenomegaly, Granulomatosis, Liver abscess, Impaired oxidative burst OMIM:233710
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Rectal abscess, Splenomegaly, Granulomatosis, Liver abscess, Impaired oxidative burst OMIM:233690
Pmm2-Cdg
Hypogonadotropic hypogonadism, Impaired neutrophil chemotaxis, Failure to thrive, Hypoalbuminemia... ORPHA:79318
Granulomatous Disease, Chronic, X-Linked
Rectal abscess, Splenomegaly, Granuloma, Granulomatosis, Liver abscess, Impaired oxidative burst OMIM:306400
Hennekam-Beemer Syndrome
Short stature, Failure to thrive, Mastocytosis ORPHA:2135
Mastocytosis
Chronic leukemia, Mastocytosis, Splenomegaly, Acute leukemia ORPHA:98292
Pde4D Haploinsufficiency Syndrome
Postnatal growth retardation, Obesity, Intrauterine growth retardation ORPHA:439822
Acrodysostosis
Short stature, Irregular menstruation, Hypogonadism ORPHA:950
Acrodysostosis 2 With Or Without Hormone Resistance
Obesity, Intrauterine growth retardation, Mild short stature OMIM:614613
Acrodysostosis With Multiple Hormone Resistance
Mild short stature, Obesity, Intrauterine growth retardation, Hypogonadism ORPHA:280651

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pde4d

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pde4d.

No publications found that use IMPC mice or data for Pde4d.

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MGI Allele Allele Type Produced
Pde4dtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Pde4dtm378682(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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