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Gene: Slx MGI:99543

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Sycp3 like X-linked
Synonyms:
EG664958,  Xmr

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slx mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Slx by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spermatogenic Failure 4
OMIM:270960
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
ORPHA:399805

The table below shows human diseases predicted to be associated to Slx by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spermatogenic Failure 4
OMIM:270960
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
ORPHA:399805

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slx

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slx.

There are 12 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts. NPJ genomic medicine (June 2022) Slx1bem1(IMPC)Ics PMC9205872
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Slx4iptm1a(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Slx4iptm1a(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Slx4tm1a(EUCOMM)Wtsi Slx4tm1a(EUCOMM)Wtsi Slx4iptm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Slx4iptm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Slx4iptm1a(EUCOMM)Wtsi PMC5827107
Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction. Genes & development (March 2016) Slx4tm1a(EUCOMM)Wtsi PMC4803051
Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Molecular cell (April 2014) Slx4tm1a(EUCOMM)Wtsi PMC4017094
Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS genetics (February 2013) Slx4tm1a(EUCOMM)Wtsi PMC3585019
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature (August 2012) Slx4tm1a(EUCOMM)Wtsi 22922648
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS genetics (June 2011) Slx4tm1a(EUCOMM)Wtsi PMC3107204
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Nature genetics (January 2011) Slx4tm1a(EUCOMM)Wtsi PMC3624090

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