Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

prostaglandin I receptor (IP)
prostacyclin receptor,  IP

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ptgir mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ptgir by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Glanzmann Thrombasthenia 2
Epistaxis, Decreased platelet glycoprotein IIb-IIIa, Impaired clot retraction, Impaired ADP-induc... OMIM:619267
Thrombocytopenia 7
Reduced platelet alpha granules, Impaired arachidonic acid-induced platelet aggregation, Reduced ... OMIM:619130
Glanzmann Thrombasthenia 1
Epistaxis, Gastrointestinal hemorrhage, Decreased platelet glycoprotein IIb-IIIa, Subdural hemorr... OMIM:273800
Bleeding Disorder, Platelet-Type, 22
Gastrointestinal hemorrhage, Impaired arachidonic acid-induced platelet aggregation, Impaired ADP... OMIM:618462
Platelet Signal Processing Defect
Epistaxis, Impaired ADP-induced platelet aggregation, Thrombocytopenia, Impaired collagen-induced... OMIM:173590
Athrombia, Essential
Impaired platelet adhesion, Prolonged bleeding time, Impaired platelet aggregation OMIM:209050
Moyamoya Disease With Early-Onset Achalasia
Raynaud phenomenon, Hypertension, Abnormal platelet aggregation, Thrombocytopenia ORPHA:401945
Bleeding Disorder, Platelet-Type, 18
Epistaxis, Impaired ADP-induced platelet aggregation, Prolonged bleeding time, Impaired epinephri... OMIM:615888
Bleeding Disorder, Platelet-Type, 24
Platelet anisocytosis, Impaired arachidonic acid-induced platelet aggregation, Impaired epinephri... OMIM:619271
Bleeding Disorder, Platelet-Type, 11
Epistaxis, Abnormal platelet count, Impaired ristocetin-induced platelet aggregation, Impaired co... OMIM:614201
Thrombocytopenia 9
Abnormal platelet aggregation, Thrombocytopenia OMIM:620478
Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss
Epistaxis, Giant platelets, Impaired ADP-induced platelet aggregation, Myocardial infarction, Thr... OMIM:155100
Bleeding Disorder, Platelet-Type, 15
Epistaxis, Platelet anisocytosis, Impaired clot retraction, Impaired ADP-induced platelet aggrega... OMIM:615193
Bleeding Disorder, Platelet-Type, 13, Susceptibility To
Impaired arachidonic acid-induced platelet aggregation, Abnormal platelet count, Impaired thrombo... OMIM:614009
Thrombocythemia 1
Impaired collagen-induced platelet aggregation, Impaired ADP-induced platelet aggregation, Impair... OMIM:187950
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
Abnormal platelet function, Thrombocytopenia ORPHA:231393
Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia
Macrothrombocytopenia, Thrombocytopenia, Impaired platelet aggregation OMIM:124900
Macrothrombocytopenia, Isolated, 1, Autosomal Dominant
Macrothrombocytopenia, Impaired platelet aggregation OMIM:613112
Bleeding Disorder, Platelet-Type, 8
Epistaxis, Impaired ADP-induced platelet aggregation OMIM:609821
Bleeding Disorder, Platelet-Type, 21
Eczematoid dermatitis, Psoriasiform dermatitis, Impaired ADP-induced platelet aggregation, Thromb... OMIM:617443
Bleeding Disorder, Platelet-Type, 25
Impaired ADP-induced platelet aggregation, Spontaneous, recurrent epistaxis, Thrombocytopenia, Ma... OMIM:620486
Bleeding Disorder, Platelet-Type, 16
Platelet anisocytosis, Giant platelets, Thrombocytopenia, Impaired platelet aggregation, Macrothr... OMIM:187800
Bernard-Soulier Syndrome
Epistaxis, Gastrointestinal hemorrhage, Giant platelets, Thrombocytopenia, Impaired ristocetin-in... OMIM:231200
Platelet Disorder, Undefined
Prolonged bleeding time, Thrombocytopenia, Impaired platelet aggregation OMIM:173420
Von Willebrand Disease, Type 3
Epistaxis, Thrombocytopenia, Impaired platelet aggregation, Joint hemorrhage, Prolonged bleeding ... OMIM:277480
Hermansky-Pudlak Syndrome 3
Spontaneous, recurrent epistaxis, Abnormal number of dense granules, Impaired platelet aggregation OMIM:614072
Hermansky-Pudlak Syndrome 9
Recurrent skin infections, Abnormal platelet aggregation, Thrombocytopenia OMIM:614171
Bleeding Disorder, Platelet-Type, 12
Epistaxis, Intestinal bleeding, Joint hemorrhage, Impaired platelet aggregation OMIM:605735
Gray Platelet Syndrome
Epistaxis, Abnormal number of alpha granules, Impaired thrombin-induced platelet aggregation, Thr... OMIM:139090
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Epistaxis, Impaired arachidonic acid-induced platelet aggregation, Abnormal dense granule content... OMIM:601399
Ataxia-Pancytopenia Syndrome
Decreased circulating antibody level, Abnormal platelet function ORPHA:2585
Von Willebrand Disease, X-Linked Form
Prolonged bleeding time OMIM:314560
Bleeding Disorder, Platelet-Type, 17
Epistaxis, Gastrointestinal hemorrhage, Absence of alpha granules, Thrombocytopenia, Macrothrombo... OMIM:187900
Quebec Platelet Disorder
Epistaxis, Joint hemorrhage, Thrombocytopenia, Impaired epinephrine-induced platelet aggregation OMIM:601709
Glanzmann Thrombasthenia
Impaired ristocetin-induced platelet aggregation, Gastrointestinal hemorrhage, Prolonged bleeding... ORPHA:849
Von Willebrand Disease, Type 1
Aortic valve stenosis, Epistaxis, Gastrointestinal hemorrhage, Impaired platelet aggregation, Joi... OMIM:193400
Hermansky-Pudlak Syndrome 7
Epistaxis, Prolonged bleeding time, Impaired platelet aggregation OMIM:614076
Sitosterolemia 1
Giant platelets, Xanthelasma, Coronary artery atherosclerosis, Carotid artery stenosis, Hyperchol... OMIM:210250
Tatsumi Factor Deficiency
Prolonged bleeding time OMIM:272650
Immunodeficiency 81
Skin rash, Impaired neutrophil chemotaxis, Reduced antigen-specific T cell proliferation, Reduced... OMIM:619374
Von Willebrand Disease, Platelet-Type
Prolonged bleeding time, Intermittent thrombocytopenia OMIM:177820
Von Willebrand Disease
Epistaxis, Gastrointestinal hemorrhage, Abnormality of thrombocytes, Muscle hemorrhage, Thrombocy... ORPHA:903
Congenital Disorder Of Glycosylation, Type Iif
Aortic regurgitation, Pulmonary hemorrhage, Decreased platelet glycoprotein Ib, Thrombocytopenia,... OMIM:603585
Hermansky-Pudlak Syndrome 5
Epistaxis, Impaired ADP-induced platelet aggregation, Absent platelet dense granules, Thrombocyto... OMIM:614074
Bernard-Soulier Syndrome, Type A2, Autosomal Dominant
Epistaxis, Impaired ADP-induced platelet aggregation, Impaired collagen-related peptide-induced p... OMIM:153670
Platelet Glycoprotein Iv Deficiency
Giant platelets, Prolonged bleeding time, Thrombocytopenia OMIM:608404
Wiskott-Aldrich Syndrome
Inflammation of the large intestine, Arrhythmia, Abnormal platelet morphology, Chronic otitis med... ORPHA:906
Pneumonia, Giant platelets, Pulmonary hemorrhage, Abnormal platelet granules, Thrombocytopenia, P... ORPHA:238459
Myh9-Related Disease
Nephritis, Giant platelets, Spontaneous, recurrent epistaxis, Myocardial infarction, Congenital t... ORPHA:182050
Bernard-Soulier Syndrome
Gastrointestinal hemorrhage, Giant platelets, Decreased platelet glycoprotein Ib-IX-V, Spontaneou... ORPHA:274
Factor V Deficiency
Epistaxis, Prolonged bleeding time, Prolonged prothrombin time OMIM:227400
Hermansky-Pudlak Syndrome 11
Epistaxis, Reduced platelet dense granules, Impaired collagen-induced platelet aggregation OMIM:619172
Autoerythrocyte Sensitization Syndrome
Impaired platelet adhesion, Gastrointestinal hemorrhage, Epistaxis, Intracranial hemorrhage, Supe... ORPHA:324636
Blue Rubber Bleb Nevus
Skin rash, Intestinal bleeding, Prolonged bleeding time ORPHA:1059
Neurofibromatosis-Noonan Syndrome
Hypertrophic cardiomyopathy, Prolonged bleeding time, Pulmonic stenosis ORPHA:638
Essential Thrombocythemia
Abnormality of thrombocytes, Transient ischemic attack, Myocardial infarction, Abnormal platelet ... ORPHA:3318
Thrombocytopenia With Beta-Thalassemia, X-Linked
Epistaxis, Reduced platelet alpha granules, Thrombocytopenia, Prolonged bleeding time, Increased ... OMIM:314050
Hermansky-Pudlak Syndrome 2
Recurrent pneumonia, Periodontitis, Enlarged platelet dense granules, Recurrent otitis media, Imp... OMIM:608233
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities
Bone marrow hypocellularity, Thrombocytopenia, Impaired platelet aggregation OMIM:300835
Hermansky-Pudlak Syndrome 6
Epistaxis, Impaired arachidonic acid-induced platelet aggregation, Impaired ADP-induced platelet ... OMIM:614075
Decreased circulating IgG level, Arrhythmia, Impaired platelet aggregation, Decreased circulating... ORPHA:79329
Prothrombin Deficiency, Congenital
Epistaxis, Gastrointestinal hemorrhage, Prolonged prothrombin time, Joint hemorrhage, Prolonged b... OMIM:613679
Wolfram Syndrome 2
Decreased circulating antibody level, Impaired collagen-induced platelet aggregation OMIM:604928
Thrombocytopenia, Paris-Trousseau Type
Prolonged bleeding time, Thrombocytopenia OMIM:188025
Ch├ędiak-Higashi Syndrome
Epistaxis, Abnormality of neutrophil physiology, Periodontitis, Increased proportion of CD25+ mas... ORPHA:167
Hermansky-Pudlak Syndrome 8
Epistaxis, Impaired platelet aggregation OMIM:614077
Hemophilia B
Intracranial hemorrhage, Joint hemorrhage, Prolonged bleeding time, Spontaneous, recurrent epistaxis ORPHA:98879
Noonan Syndrome
Abnormal EKG, Hypertrophic cardiomyopathy, Pulmonary artery stenosis, Arrhythmia, Abnormal platel... ORPHA:648
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Impaired platelet aggregation OMIM:618372
Leukocyte Adhesion Deficiency
Pneumonia, Bone marrow hypocellularity, Abnormality of neutrophil physiology, Vaginitis, Impaired... ORPHA:2968
Pseudohypoparathyroidism Type 1A
Prolonged QT interval, Conjunctivitis, Abnormal platelet function, Hypertension ORPHA:79443
Mixed Connective Tissue Disease
Gastrointestinal hemorrhage, Skin rash, Myositis, Gastritis, Pulmonary arterial hypertension, Ker... ORPHA:809
Hermansky-Pudlak Syndrome 1
Hematochezia, Inflammation of the large intestine, Epistaxis, Cardiomyopathy, Colitis, Prolonged ... OMIM:203300
Wiskott-Aldrich Syndrome
Decreased mean platelet volume, Epistaxis, Inflammation of the large intestine, Recurrent pneumon... OMIM:301000
Storage Pool Platelet Disease
Decreased mean platelet volume, Prolonged bleeding time OMIM:185050
Bartter Syndrome, Type 2, Antenatal
Hyperaldosteronism, Low-to-normal blood pressure, Impaired platelet aggregation OMIM:241200


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ptgir

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ptgir.

No publications found that use IMPC mice or data for Ptgir.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter