Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

prostaglandin I receptor (IP)

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ptgir mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ptgir by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Glanzmann Thrombasthenia 2
Prolonged bleeding time, Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced ... OMIM:619267
Thrombocytopenia 7
Reduced platelet alpha granules, Impaired ADP-induced platelet aggregation, Impaired collagen-ind... OMIM:619130
Platelet Signal Processing Defect
Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced platelet aggregation, Epi... OMIM:173590
Athrombia, Essential
Impaired platelet aggregation, Impaired platelet adhesion, Prolonged bleeding time OMIM:209050
Moyamoya Disease With Early-Onset Achalasia
Thrombocytopenia, Abnormal platelet aggregation, Raynaud phenomenon, Hypertension ORPHA:401945
Glanzmann Thrombasthenia 1
Impaired platelet aggregation, Prolonged bleeding time, Gastrointestinal hemorrhage, Intracranial... OMIM:273800
Platelet Aggregation, Spontaneous
Spontaneous platelet aggregation, Abnormal platelet function OMIM:173400
Bleeding Disorder, Platelet-Type, 18
Impaired platelet aggregation, Prolonged bleeding time, Epistaxis OMIM:615888
Bleeding Disorder, Platelet-Type, 24
Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced platelet aggregation, Inc... OMIM:619271
+173470 integrin, beta-3
Impaired platelet aggregation, Gastrointestinal hemorrhage, Intracranial hemorrhage, Epistaxis, D... OMIM:173470
Thrombocythemia 1
Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced platelet aggregation, Thr... OMIM:187950
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
Thrombocytopenia, Abnormal platelet function ORPHA:231393
Bleeding Disorder, Platelet-Type, 22
Impaired platelet aggregation OMIM:618462
Bleeding Disorder, Platelet-Type, 13, Susceptibility To
Impaired thromboxane A2 agonist-induced platelet aggregation, Epistaxis OMIM:614009
Bleeding Disorder, Platelet-Type, 8
Impaired ADP-induced platelet aggregation, Epistaxis OMIM:609821
Von Willebrand Disease
Abnormal thrombocyte morphology, Abnormal platelet function ORPHA:903
Platelet Responsiveness To Adrenaline, Depressed
Impaired epinephrine-induced platelet aggregation OMIM:173580
Bleeding Disorder, Platelet-Type, 16
Impaired platelet aggregation, Macrothrombocytopenia, Thrombocytopenia, Giant platelets, Platelet... OMIM:187800
Von Willebrand Disease, Type 3
Impaired platelet aggregation, Joint hemorrhage, Prolonged bleeding time, Epistaxis, Thrombocytop... OMIM:277480
Platelet Disorder, Undefined
Impaired platelet aggregation, Thrombocytopenia, Prolonged bleeding time OMIM:173420
Bleeding Disorder, Platelet-Type, 21
Impaired platelet aggregation, Eczema, Thrombocytopenia, Psoriasiform dermatitis OMIM:617443
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Impaired platelet aggregation, Prolonged bleeding time, Abnormal alpha granule content, Abnormal ... OMIM:601399
Bernard-Soulier Syndrome
Prolonged bleeding time, Gastrointestinal hemorrhage, Epistaxis, Thrombocytopenia, Impaired risto... OMIM:231200
Bleeding Disorder, Platelet-Type, 12
Impaired platelet aggregation, Joint hemorrhage, Intestinal bleeding, Epistaxis OMIM:605735
Gray Platelet Syndrome
Prolonged bleeding time, Abnormal number of alpha granules, Impaired thrombin-induced platelet ag... OMIM:139090
Quebec Platelet Disorder
Impaired epinephrine-induced platelet aggregation, Thrombocytopenia, Joint hemorrhage, Epistaxis OMIM:601709
Von Willebrand Disease, X-Linked Form
Prolonged bleeding time OMIM:314560
Sitosterolemia 1
Impaired platelet aggregation, Hypercholesterolemia, Coronary artery atherosclerosis, Giant plate... OMIM:210250
Von Willebrand Disease, Type 1
Impaired platelet aggregation, Joint hemorrhage, Prolonged bleeding time, Gastrointestinal hemorr... OMIM:193400
Ataxia-Pancytopenia Syndrome
Decreased circulating antibody level, Abnormal platelet function ORPHA:2585
Glanzmann Thrombasthenia
Spontaneous, recurrent epistaxis, Impaired ristocetin-induced platelet aggregation, Prolonged ble... ORPHA:849
Immunodeficiency 81
Skin rash, Impaired neutrophil chemotaxis, Impaired collagen-induced platelet aggregation, Recurr... OMIM:619374
Tatsumi Factor Deficiency
Prolonged bleeding time OMIM:272650
Hermansky-Pudlak Syndrome 7
Impaired platelet aggregation, Epistaxis OMIM:614076
Pseudo-Von Willebrand Disease
Prolonged bleeding time, Intermittent thrombocytopenia OMIM:177820
Hermansky-Pudlak Syndrome 6
Impaired ADP-induced platelet aggregation, Prolonged bleeding time, Epistaxis, Abnormal platelet ... OMIM:614075
Platelet Glycoprotein Iv Deficiency
Thrombocytopenia, Prolonged bleeding time, Giant platelets OMIM:608404
Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss
Prolonged bleeding time, Epistaxis, Thrombocytopenia, Myocardial infarction, Giant platelets OMIM:155100
Bleeding Disorder, Platelet-Type, 14
Prolonged bleeding time, Epistaxis OMIM:614158
Sebastian syndrome
Thrombocytopenia, Giant platelets, Prolonged bleeding time, Epistaxis OMIM:605249
Congenital Disorder Of Glycosylation, Type Iif
Pulmonary hemorrhage, Aortic regurgitation, Macrothrombocytopenia, Thrombocytopenia, Decreased pl... OMIM:603585
Bleeding Disorder, Platelet-Type, 11
Prolonged bleeding time, Epistaxis OMIM:614201
Macrothrombocytopenia and progressive sensorineural deafness
Thrombocytopenia, Prolonged bleeding time, Giant platelets, Macrothrombocytopenia OMIM:600208
Myh9-Related Disease
Prolonged bleeding time, Spontaneous, recurrent epistaxis, Congenital thrombocytopenia, Increased... ORPHA:182050
Pulmonary hemorrhage, Prolonged bleeding time, Pneumonia, Thrombocytopenia, Giant platelets, Abno... ORPHA:238459
Wiskott-Aldrich Syndrome
Intracranial hemorrhage, Sinusitis, Eczema, Otitis media, Epistaxis, Sudden cardiac death, Thromb... ORPHA:906
Hermansky-Pudlak Syndrome 11
Reduced platelet dense granules, Epistaxis, Impaired collagen-induced platelet aggregation OMIM:619172
Hermansky-Pudlak Syndrome 8
Impaired platelet aggregation, Epistaxis OMIM:614077
Autoerythrocyte Sensitization Syndrome
Thrombocytosis, Joint hemorrhage, Impaired platelet adhesion, Gastrointestinal hemorrhage, Autoim... ORPHA:324636
Factor V Deficiency
Prolonged bleeding time, Epistaxis, Prolonged prothrombin time OMIM:227400
Neurofibromatosis-Noonan Syndrome
Pulmonic stenosis, Prolonged bleeding time, Hypertrophic cardiomyopathy ORPHA:638
Hermansky-Pudlak Syndrome 2
Prolonged bleeding time, Chronic oral candidiasis, Recurrent otitis media, Impaired ADP-induced p... OMIM:608233
Bernard-Soulier Syndrome
Gastrointestinal hemorrhage, Hematemesis, Spontaneous, recurrent epistaxis, Macrothrombocytopenia... ORPHA:274
Blue Rubber Bleb Nevus
Skin rash, Prolonged bleeding time, Intestinal bleeding ORPHA:1059
Essential Thrombocythemia
Prolonged bleeding time, Myocardial infarction, Abnormal thrombocyte morphology, Transient ischem... ORPHA:3318
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities
Impaired platelet aggregation, Thrombocytopenia, Abnormal platelet morphology OMIM:300835
Prothrombin Deficiency, Congenital
Joint hemorrhage, Prolonged bleeding time, Gastrointestinal hemorrhage, Epistaxis, Prolonged prot... OMIM:613679
Thrombocytopenia With Beta-Thalassemia, X-Linked
Thrombocytopenia, Prolonged bleeding time, Epistaxis OMIM:314050
Aplasia Cutis Congenita
Prolonged bleeding time ORPHA:1114
Fechtner syndrome
Thrombocytopenia, Nephritis, Prolonged bleeding time, Giant platelets OMIM:153640
Chédiak-Higashi Syndrome
Increased proportion of CD25+ mast cells, Skin rash, Recurrent bacterial skin infections, Periodo... ORPHA:167
Wiskott-Aldrich Syndrome, Autosomal Dominant
Inflammation of the large intestine, Decreased mean platelet volume, Small vessel vasculitis, Pro... OMIM:600903
Thrombocytopenia, Paris-Trousseau Type
Thrombocytopenia, Prolonged bleeding time OMIM:188025
Bleeding Disorder, Platelet-Type, 17
Prolonged bleeding time, Gastrointestinal hemorrhage, Epistaxis, Thrombocytopenia, Absence of alp... OMIM:187900
Hemophilia B
Intracranial hemorrhage, Joint hemorrhage, Spontaneous, recurrent epistaxis, Prolonged bleeding time ORPHA:98879
Leukocyte Adhesion Deficiency
Impaired platelet aggregation, Peritonitis, Osteomyelitis, Thrombocytosis, Severe periodontitis, ... ORPHA:2968
Wolfram Syndrome 2
Decreased circulating antibody level, Impaired collagen-induced platelet aggregation OMIM:604928
Klippel-Trénaunay Syndrome
Prolonged bleeding time, Gastrointestinal hemorrhage, Internal hemorrhage, Pulmonary embolism, Co... ORPHA:90308
Deafness-Lymphedema-Leukemia Syndrome
Prolonged bleeding time, Intracranial hemorrhage, Chronic otitis media, Thrombocytopenia, Bone ma... ORPHA:3226
Noonan Syndrome
Arrhythmia, Pulmonary artery stenosis, Abnormal platelet function ORPHA:648
Hermansky-Pudlak Syndrome 5
Thrombocytopenia, Prolonged bleeding time, Epistaxis OMIM:614074
Hermansky-Pudlak Syndrome 1
Inflammation of the large intestine, Prolonged bleeding time, Hematochezia, Epistaxis, Colitis, C... OMIM:203300
Pseudohypoparathyroidism Type 1A
Conjunctivitis, Prolonged QT interval, Hypertension, Abnormal platelet function ORPHA:79443
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Impaired platelet aggregation OMIM:618372
Mixed Connective Tissue Disease
Skin rash, Prolonged bleeding time, Pericarditis, Gastrointestinal hemorrhage, Keratoconjunctivit... ORPHA:809
Wiskott-Aldrich Syndrome
Inflammation of the large intestine, Recurrent pneumonia, Decreased mean platelet volume, Small v... OMIM:301000
Storage Pool Platelet Disease
Decreased mean platelet volume, Prolonged bleeding time OMIM:185050
Bartter Syndrome, Type 2, Antenatal
Impaired platelet aggregation, Low-to-normal blood pressure, Hyperaldosteronism OMIM:241200


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ptgir

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ptgir.

No publications found that use IMPC mice or data for Ptgir.

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