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Gene: Hspa1b MGI:99517

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
heat shock protein 1B
Synonyms:
HSP70B1,  hsp68,  Hsp70.1,  Hsp70-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Hspa1b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Hspa1b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Primary Erythromelalgia
Hypothermia ORPHA:90026
Riboflavin Deficiency
Hypothermia OMIM:615026
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Spontaneous Periodic Hypothermia
Hypothermia ORPHA:29822
Idiopathic Congenital Hypothyroidism
Hypothermia ORPHA:95717
Coenzyme Q10 Deficiency, Primary, 5
Hypothermia OMIM:614654
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypothermia OMIM:245400
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Hypothermia OMIM:614498
Sepsis In Premature Infants
Temperature instability, Fever, Hypothermia, Cyanosis, Increased circulating interleukin 6 concen... ORPHA:90051
Meningococcal Meningitis
Fever, Hypothermia ORPHA:33475
Menkes Disease
Hypothermia OMIM:309400
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Hypothermia ORPHA:226313
Timothy Syndrome
Hypothermia OMIM:601005
Familial Thyroid Dyshormonogenesis
Hypothermia ORPHA:95716
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Fever, Abnormality of temperature regulation, Hypothermia OMIM:618493
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
N-Acetylglutamate Synthase Deficiency
Hypothermia OMIM:237310
Carnitine-Acylcarnitine Translocase Deficiency
Hypothermia, Cyanosis ORPHA:159
Congenital Enterovirus Infection
Fever, Hypothermia ORPHA:292
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia OMIM:618775
Genetic Transient Congenital Hypothyroidism
Hypothermia ORPHA:226316
Adult Acute Respiratory Distress Syndrome
Abnormal circulating interleukin concentration, Abnormality of tumor necrosis factor secretion, A... ORPHA:70578
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypothermia ORPHA:26793
3-Hydroxy-3-Methylglutaric Aciduria
Fever, Hypothermia ORPHA:20
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia OMIM:618329
Hypothyroidism Due To Tsh Receptor Mutations
Hypothermia ORPHA:90673
Ethylene Glycol Poisoning
Hypothermia, Cyanosis ORPHA:31826
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypothermia OMIM:251880
Dopamine Beta-Hydroxylase Deficiency
Hypothermia ORPHA:230
Aromatic L-Amino Acid Decarboxylase Deficiency
Intermittent hypothermia, Temperature instability OMIM:608643
Tbck-Related Intellectual Disability Syndrome
Hypothermia ORPHA:488632
Car T Cell Therapy-Associated Cytokine Release Syndrome
Abnormal circulating interleukin concentration, Fever, Increased circulating interferon-gamma con... ORPHA:542323
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Hypothermia ORPHA:99027
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Alexander Disease
Hypothermia ORPHA:58
Neuroleptic Malignant Syndrome
Fever, Hypothermia ORPHA:94093
Mitochondrial Dna-Associated Leigh Syndrome
Fever, Hypothermia ORPHA:255210
Isolated Thyroid-Stimulating Hormone Deficiency
Hypothermia ORPHA:90674
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypothermia ORPHA:17
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypothermia ORPHA:79282
Macrophage Activation Syndrome
Abnormal circulating interleukin concentration, Fever, Abnormality of tumor necrosis factor secre... ORPHA:158061
Menkes Disease
Hypothermia ORPHA:565
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Fever, Hypothermia, Cyanosis ORPHA:293987
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia ORPHA:226307
Marburg Hemorrhagic Fever
Fever, Hypothermia, Increased circulating antibody level ORPHA:99826
Occipital Horn Syndrome
Hypothermia ORPHA:198
Hypothyroidism, Congenital, Nongoitrous, 2
Hypothermia OMIM:218700
Hereditary Sensory And Autonomic Neuropathy Type 4
Unexplained fevers, Hypothermia, Recurrent fever ORPHA:642
Sarcoidosis
Fever, Hypothermia ORPHA:797
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Hypothermia ORPHA:438213
Aregenerative Anemia
Abnormal circulating interleukin concentration, Fever ORPHA:101096

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hspa1b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hspa1b.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome medicine (May 2024) Tg(RARE-Hspa1b/lacZ)12Jrt PMC11140907

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