Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
caveolae associated 2
Synonyms:
cavin 2,  Sdpr

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cavin2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cavin2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pulmonary Atresia With Intact Ventricular Septum
Pulmonary artery atresia OMIM:265150
Pulmonary Atresia With Ventricular Septal Defect
Pulmonary artery atresia OMIM:178370
Heart Defects-Limb Shortening Syndrome
Abnormality of the pulmonary artery ORPHA:1354
Congenital Unilateral Hypoplasia Of Depressor Anguli Oris
Cryptorchidism, Abnormality of the pulmonary artery, Congenital diaphragmatic hernia, Abnormal ao... ORPHA:1166
Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome
Abnormality of the pulmonary artery ORPHA:1065
Waardenburg Syndrome Type 2
Abnormality of the pulmonary artery ORPHA:895
Duodenal Atresia
Abnormality of the pulmonary artery ORPHA:1203
Congenital Rubella Syndrome
Abnormality of the pulmonary artery ORPHA:290
Klippel-Trénaunay Syndrome
Abnormality of the pulmonary artery, Cellulitis ORPHA:90308
Diabetic Embryopathy
Cryptorchidism, Abnormality of the pulmonary artery, Abnormal aortic morphology ORPHA:1926
Pulmonary Hypertension, Primary, 1
Pulmonary aterial intimal fibrosis, Pulmonary arterial medial hypertrophy, Pulmonary artery vasoc... OMIM:178600
Lmna-Related Cardiocutaneous Progeria Syndrome
Lipoatrophy, Aortic root aneurysm, Aortic atherosclerotic lesion, Emphysema, Abnormality of the p... ORPHA:363618
X-Linked Mandibulofacial Dysostosis
Cryptorchidism, Abnormality of the pulmonary artery ORPHA:1131
Pagod Syndrome
Omphalocele, Congenital diaphragmatic hernia, Pulmonary artery hypoplasia, Abnormal aortic morpho... ORPHA:991
Dextrocardia
Abnormality of the pulmonary artery, Abnormal lung lobation, Abnormal pulmonary situs morphology ORPHA:1666
Noonan Syndrome With Multiple Lentigines
Cryptorchidism, Abnormality of the pulmonary artery ORPHA:500
Atypical Werner Syndrome
Coronary artery atherosclerosis, Lipoatrophy, Peripheral arterial stenosis, Generalized lipodystr... ORPHA:79474
Peters Plus Syndrome
Inguinal hernia, Cryptorchidism, Abnormal pulmonary vein morphology, Umbilical hernia, Abnormalit... ORPHA:709
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Pulmonary artery sling, Cryptorchidism, Flexion contracture, Coarctation of aorta, Hydrocele test... ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Pulmonary artery sling, Cryptorchidism, Flexion contracture, Coarctation of aorta, Hydrocele test... ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cavin2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cavin2.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nature communications (January 2013) Cavin2tm1(KOMP)Vlcg PMC3674239

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cavin2tm284548(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cavin2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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