Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

epoxide hydrolase 2, cytoplasmic
sEH,  sEP,  Eph2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ephx2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ephx2 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Hypercholesterolemia, Familial, 1
Xanthelasma OMIM:143890

The table below shows human diseases predicted to be associated to Ephx2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Exudative Vitreoretinopathy 2, X-Linked
Subretinal exudate, Exudative vitreoretinopathy, Retinal hole, Peripheral vitreous opacities, Ret... OMIM:305390
Central Retinal Vein Occlusion
Intraretinal hemorrhage, Macular edema, Macular degeneration, Papilledema, Retinal neovasculariza... ORPHA:411527
Vitreoretinopathy, Neovascular Inflammatory
Vitreoretinopathy, Large hyperpigmented retinal spots, Peripheral retinal neovascularization, Ret... OMIM:193235
Familial Exudative Vitreoretinopathy
Rhegmatogenous retinal detachment, Tractional retinal detachment, Vitreous floaters, Vitreoretino... ORPHA:891
Exudative Vitreoretinopathy 1
Exudative vitreoretinopathy, Peripheral retinal avascularization, Retinal exudate, Retinal detach... OMIM:133780
Congenital Tricuspid Stenosis
Tricuspid stenosis, Pulmonary arterial hypertension, Tricuspid regurgitation, Congestive heart fa... ORPHA:95459
Corticosteroid-Binding Globulin Deficiency
Hypertension, Hypotension OMIM:611489
Metachromatic Leukodystrophy, Adult-Onset, With Normal Arylsulfatase A
Hypotension OMIM:156310
Eales Disease
Rhegmatogenous retinal detachment, Optic disc pallor, Tractional retinal detachment, Vitreous flo... ORPHA:40923
Retinal Venous Beading
Retinal neovascularization, Abnormal distribution of retinal arterioles and venules, Retinal infa... OMIM:180080
Tachycardia, Hypotension OMIM:236800
Abnormality of chorioretinal pigmentation, Retinal detachment, Vitreous hemorrhage, Retinal neova... OMIM:193220
Tako-Tsubo Cardiomyopathy
Syncope, Hypertension, Prolonged QT interval, Decreased QRS voltage, Ventricular arrhythmia, Mitr... ORPHA:66529
Obesity Due To Sim1 Deficiency
Postural hypotension with compensatory tachycardia, Hypotension ORPHA:369873
Cardiogenic Shock
Right ventricular failure, Mitral regurgitation, Low pulse pressure, Elevated jugular venous pres... ORPHA:97292
Perry Syndrome
Hypotension ORPHA:178509
Hypotension OMIM:616000
Snakebite Envenomation
Intracranial hemorrhage, Epistaxis, Tachycardia, Cerebral ischemia, Cardiogenic shock, Myocardial... ORPHA:449285
Chromosome 5Q12 Deletion Syndrome
Hypotension OMIM:615668
Infant Acute Respiratory Distress Syndrome
Cardiac arrest, Tachycardia, Bradycardia, Hypotension ORPHA:70587
Nipah Virus Disease
Hypotension ORPHA:99825
Malignant Hyperthermia, Susceptibility To, 1
Tachycardia, Hypotension OMIM:145600
Carnitine-Acylcarnitine Translocase Deficiency
Premature ventricular contraction, Ventricular tachycardia, Atrioventricular block, Cardiomyopath... OMIM:212138
Late-Onset Familial Hypoaldosteronism
Orthostatic hypotension, Hypotension ORPHA:556037
Erythrocytosis, Familial, 2
Cerebral hemorrhage, Hypotension OMIM:263400
Glycogen Storage Disease Of Heart, Lethal Congenital
Bradycardia, Cardiomyopathy, Congestive heart failure, Shortened PR interval, Hypotension OMIM:261740
Acquired Von Willebrand Syndrome
Intracranial hemorrhage, Mitral regurgitation, Aortic regurgitation, Epistaxis, Joint hemorrhage,... ORPHA:99147
Adult Acute Respiratory Distress Syndrome
Shock, Vasculitis, Hypotension ORPHA:70578
Neuroendocrine Tumor Of The Colon
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100080
Cleft Palate, Proliferative Retinopathy, And Developmental Delay
Retinal neovascularization OMIM:619074
Cutaneous Mastocytoma
Telangiectasia macularis eruptiva perstans, Telangiectasia of the skin, Hypotension ORPHA:79455
Early-Onset Familial Hypoaldosteronism
Orthostatic hypotension, Hypotension ORPHA:556030
Neuroendocrine Tumor Of The Rectum
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100082
Car T Cell Therapy-Associated Cytokine Release Syndrome
Reduced ejection fraction, Tachycardia, Heart block, Arrhythmia, Hypotension, Capillary leak ORPHA:542323
Dengue Fever
Cerebral hemorrhage, Gastrointestinal hemorrhage, Epistaxis, Hypotension ORPHA:99828
Tachycardia, Hypotension ORPHA:79155
Inhalational Anthrax
Internal hemorrhage, Hypotension ORPHA:247257
Neurodevelopmental Disorder With Seizures And Speech And Walking Impairment
Hypotension OMIM:618480
Corticosterone Methyloxidase Type I Deficiency
Hypotension OMIM:203400
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Abnormal retinal vascular morphology, Retinal neovascularization, Macular edema, Retinal cotton w... ORPHA:247691
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Systemic Capillary Leak Syndrome
Myocarditis, Arrhythmia, Pericarditis, Hypotension ORPHA:188
Bronchial Neuroendocrine Tumor
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Cardioge... ORPHA:97287
Congenital Isolated Acth Deficiency
Hypotension ORPHA:199296
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Hypotension OMIM:264350
Renal Tubular Dysgenesis
Hypotension OMIM:267430
Mercury Poisoning
Hypertension, Tachycardia, Hypotension ORPHA:330021
Infant Botulism
Hypertension, Cardiac arrest, Hypotension ORPHA:178478
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension OMIM:177735
Familial Hypoaldosteronism
Orthostatic hypotension, Hypovolemia, Hypotension ORPHA:427
Ileal Neuroendocrine Tumor
Right ventricular failure, Tricuspid stenosis, Palpitations, Arterial occlusion, Pulmonic stenosi... ORPHA:100078
Jejunal Neuroendocrine Tumor
Right ventricular failure, Tricuspid stenosis, Palpitations, Arterial occlusion, Pulmonic stenosi... ORPHA:100077
Neuroendocrine Tumor Of Stomach
Right ventricular failure, Facial telangiectasia, Palpitations, Tricuspid regurgitation, Melena, ... ORPHA:100075
Post-Traumatic Pituitary Deficiency
Hypotension ORPHA:95619
Scrub Typhus
Myocarditis, Hypotension ORPHA:83317
Aa Amyloidosis
Hypotension ORPHA:85445
Colchicine Poisoning
Myocarditis, Cardiogenic shock, Congestive heart failure, Hypovolemia, Arrhythmia, Hypotension ORPHA:31824
Meningococcal Meningitis
Shock, Hypotension ORPHA:33475
Cocaine Intoxication
Cerebral hemorrhage, Hypertension, Prolonged QT interval, Ventricular arrhythmia, Tachycardia, My... ORPHA:90068
Carnitine-Acylcarnitine Translocase Deficiency
Ventricular tachycardia, Cardiomyopathy, Arrhythmia, Hypotension ORPHA:159
Relapsing Fever
Epistaxis, Tachycardia, Hypotension ORPHA:91547
Necrotizing Enterocolitis
Shock, Bradycardia, Hypotension ORPHA:391673
Legionnaires Disease
Myocarditis, Arrhythmia, Pericarditis, Hypotension ORPHA:549
Whipple Disease
Myocarditis, Pericarditis, Myocardial infarction, Gastrointestinal hemorrhage, Hypotension ORPHA:3452
Congenital Hypothyroidism
Hypertension, Arrhythmia, Hypotension ORPHA:442
Aggressive Systemic Mastocytosis
Gastrointestinal hemorrhage, Portal hypertension, Hypotension ORPHA:98850
Pde4D Haploinsufficiency Syndrome
Hypotension ORPHA:439822
Diffuse Cutaneous Mastocytosis
Gastrointestinal hemorrhage, Hypotension ORPHA:79456
Serotonin Syndrome
Hypertension, Tachycardia, Hypotension ORPHA:43116
Gastrointestinal hemorrhage, Arrhythmia, Telangiectasia of the skin, Hypotension ORPHA:98292
Congenital Enterovirus Infection
Myocarditis, Cardiomyopathy, Hypotension ORPHA:292
Ethylene Glycol Poisoning
Shock, Hypertension, Prolonged QT interval, Atrial fibrillation, Tachycardia, Congestive heart fa... ORPHA:31826
Duodenal Neuroendocrine Tumor
Right ventricular failure, Tricuspid stenosis, Palpitations, Melena, Pulmonic stenosis, Cardiogen... ORPHA:100076
Staphylococcal Necrotizing Pneumonia
Shock, Hypotension ORPHA:36238
Hypertension, Hypovolemic shock, Hypotension ORPHA:2912
Bacterial Toxic-Shock Syndrome
Myocarditis, Shock, Tachycardia, Hypotension, Capillary leak ORPHA:36234
Crimean-Congo Hemorrhagic Fever
Myocarditis, Hypertension, Retinal hemorrhage, Subdural hemorrhage, Subconjunctival hemorrhage, H... ORPHA:99827
Neuroleptic Malignant Syndrome
Hypertension, Hypertensive crisis, Tachycardia, Bradycardia, Pulmonary embolism, Arrhythmia, Hypo... ORPHA:94093
Hennekam-Beemer Syndrome
Arrhythmia, Telangiectasia of the skin, Hypotension ORPHA:2135
Hemorrhagic Fever-Renal Syndrome
Shock, Hypertension, Intracranial hemorrhage, Palpitations, Subconjunctival hemorrhage, Epistaxis... ORPHA:340
Beta-Ketothiolase Deficiency
Hypertension, Hypotension ORPHA:134
Hypovolemic shock, Tachycardia, Hypotension ORPHA:173
Lujo Hemorrhagic Fever
Myocarditis, Shock, Subconjunctival hemorrhage, Bradycardia, Hypotension ORPHA:319213
Gitelman Syndrome
Palpitations, Prolonged QT interval, Hypotension, Ventricular tachycardia OMIM:263800
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Hypertension, Hypotension OMIM:174000
Systemic Mastocytosis With Associated Hematologic Neoplasm
Syncope, Tachycardia, Hypotension ORPHA:98849
Sepsis In Premature Infants
Tachycardia, Hypotension, Bradycardia ORPHA:90051
Pituitary Apoplexy
Hypertension, Hypotension ORPHA:95613
Autosomal Dominant Hypocalcemia
Congestive heart failure, Arrhythmia, Hypotension ORPHA:428
Familial Glucocorticoid Deficiency
Hypertrophic cardiomyopathy, Hypotension ORPHA:361
Acute Adrenal Insufficiency
Orthostatic hypotension, Myocardial infarction, Hypotension, Hypovolemia ORPHA:95409
3-Hydroxy-3-Methylglutaric Aciduria
Dilated cardiomyopathy, Cardiac arrest, Hypotension ORPHA:20
Late-Onset Isolated Acth Deficiency
Orthostatic hypotension, Hypotension ORPHA:199299
Fragile X-Associated Tremor/Ataxia Syndrome
Hypertension, Hypotension ORPHA:93256
Alexander Disease
Sudden cardiac death, Hypertension, Hypotension ORPHA:58
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension OMIM:608643
Hellp Syndrome
Cerebral hemorrhage, Internal hemorrhage, Hypotension ORPHA:244242
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Hypotension ORPHA:293978
Bartter Syndrome, Type 3
Hypotension OMIM:607364
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypotension ORPHA:90791
Neuroendocrine Neoplasm Of Appendix
Palpitations, Tricuspid stenosis, Heart murmur, Hypotension ORPHA:100079
Tsh-Secreting Pituitary Adenoma
Hypertension, Ventricular arrhythmia, Palpitations, Congestive heart failure, Supraventricular ar... ORPHA:91347
Hypotension ORPHA:2965
Exercise-Induced Malignant Hyperthermia
Abnormal T-wave, Prolonged QT interval, ST segment depression, Abnormal pulse pressure, Hypotensi... ORPHA:466650
Hereditary Angioedema Type 1
Hypotension ORPHA:100050
Marburg Hemorrhagic Fever
Shock, Pericarditis, Subconjunctival hemorrhage, Tachycardia, Bradycardia, Hypovolemia, Internal ... ORPHA:99826
Hepatocellular Carcinoma
Portal hypertension, Hypotension, Internal hemorrhage, Budd-Chiari syndrome ORPHA:88673
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hypovolemia, Hypotension ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hypovolemia, Hypotension ORPHA:289548
Lysosomal Acid Lipase Deficiency
Hypovolemia, Pulmonary arterial hypertension, Hypotension ORPHA:275761
Pericarditis, Retinal hemorrhage, Subconjunctival hemorrhage, Pulmonary hemorrhage, First degree ... ORPHA:509
Addison Disease
Orthostatic hypotension, Hypotension ORPHA:85138
Acute Liver Failure
Shock, Gastrointestinal hemorrhage, Intracranial hemorrhage, Hypotension ORPHA:90062
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Hypovolemia, Shock, Hypotension ORPHA:90794
Arrhythmia, Hematemesis, Tachycardia, Hypotension ORPHA:707
Non-Acquired Panhypopituitarism
Hypotension ORPHA:90695
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypotension ORPHA:95494
Hypercholesterolemia, Familial, 1
Xanthelasma OMIM:143890


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ephx2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ephx2.

No publications found that use IMPC mice or data for Ephx2.

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MGI Allele Allele Type Produced
Ephx2tm83826(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ephx2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ephx2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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