Arrb2 | arrestin, beta 2

GeneMGI:99474Synonyms: Arr3, beta-arrestin2, +3 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

15 No significant impact

7 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
47Embryo tissues

Phenotypes

increased circulating alkaline phosphatase level1 supporting datasetArrb2tm1.1(KOMP)VlcghomozygoteEarly adult1.33x10-16 
increased circulating cholesterol level1 supporting datasetArrb2tm1.1(KOMP)VlcghomozygoteEarly adult3.14x10-6 
increased grip strength2 supporting datasetsArrb2tm1.1(KOMP)VlcghomozygoteEarly adult9.38x10-6 
increased circulating HDL cholesterol level1 supporting datasetArrb2tm1.1(KOMP)VlcghomozygoteEarly adult1.17x10-6 
increased circulating phosphate level1 supporting datasetArrb2tm1.1(KOMP)VlcghomozygoteEarly adult4.64x10-5 
increased circulating free fatty acids level1 supporting datasetArrb2tm1.1(KOMP)VlcgheterozygoteEarly adult2.22x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
50% (1/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteSection images
100% (2/2)0.22% (1/454)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteSection images
100% (2/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Arrb2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Arrb2tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Arrb2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Arrb2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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