Gene: Notch3

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal heart morphology Notch3tm1.1(KOMP)Vlcg HOM Early adult 0.00
enlarged kidney Notch3tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased lung weight Notch3tm1.1(KOMP)Vlcg HOM   Early adult 5.57×10-05
abnormal kidney morphology Notch3tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased liver weight Notch3tm1.1(KOMP)Vlcg HOM   Early adult 0.00
improved glucose tolerance Notch3tm1.1(KOMP)Vlcg HOM Early adult 6.07×10-18
decreased prepulse inhibition Notch3tm1.1(KOMP)Vlcg HOM   Early adult 2.89×10-05
enlarged heart Notch3tm1.1(KOMP)Vlcg HOM Early adult 0.00
increased lean body mass Notch3tm1.1(KOMP)Vlcg HOM Early adult 4.69×10-07

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Blood 2 No N/A
Bone marrow 2 No  (1/2)  Section images
Brain 2 No  (3/590) N/A
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No N/A
Cecum 2 No  (12/377)  (1/2)  Section images
Cerebellum 2 No  (3/590)  (1/2)  Section images
Cerebral cortex 2 No  (2/590) N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (1/2)  Section images
Diaphragm 2 No  (1/2)  Section images
Duodenum 2 No  (2/127)  (1/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (1/2)  Section images
Eye 2 No N/A
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2)  Section images
Harderian gland 2 No  (1/2)  Section images
Heart 2 No  (1/590) N/A
Hindlimb 2 No N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Ileum 2 No  (14/127)  (2/2)  Section images
Jejunum 2 No  (6/127) N/A
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590) N/A
Liver 2 No  (1/2)  Section images
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590)  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No  (1/2)  Section images
Mesenteric adipose tissue 2 No  (2/2)  Section images
Mesenteric lymph node 2 No N/A
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/590)  (2/2)  Section images
Parathyroid gland 2 No N/A
Parotid gland 2 No N/A
Penis 2 No  (1/2)  Section images
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590)  (1/2)  Section images
Quadriceps 2 No  (2/2)  Section images
Sciatic nerve 2 No  (1/2)  Section images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590)  (2/2)  Section images
Stomach 2 No  (13/590)  (2/2)  Section images
Stomach pyloric region 2 No N/A
Striatum 2 No  (3/590) N/A
Sublingual gland 2 No N/A
Submandibular gland 2 No  (2/132)  (1/2)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Tongue 2 No  (5/127)  (2/2)  Section images
Trachea 2 No  (2/590)  (1/2)  Section images
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vagina 2 No  Section images
Vas deferens 2 No  (15/388)  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No  (1/2)  Section images
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
20 Images
Adult LacZ: LacZ Images Section
84 Images
X-ray: XRay Images Whole Body Dorso Ventral
20 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Notch3tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Notch3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Notch3tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Notch3tm48394(L1L2_Bact_P) Targeting vectors

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