Gene Summary

Name:
zinc finger protein 7
Synonyms:
KRAB20,  mszf73-2,  Zfp65,  Zfp86-rs1,  Krox-2,  KRAB7,  Zfp-7,  Zfp80

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

Human diseases caused by Zfp7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp7.

There are 7 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Zfp712em1(IMPC)Wtsi Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp748em1(IMPC)Wtsi Zfp763em1(IMPC)Wtsi Zfp791tm1a(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp763em1(IMPC)Wtsi Zfp791tm1a(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp748em1(IMPC)Wtsi Zfp748em1(IMPC)Wtsi Zfp763em2Wtsi Zfp791tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp763em1Wtsi Zfp791tm1a(KOMP)Wtsi PMC6459510
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature communications (October 2017) Zfp719tm1b(EUCOMM)Wtsi PMC5638796
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp763em2Wtsi Zfp791tm1a(KOMP)Wtsi PMC5827107
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Disease models & mechanisms (August 2015) Zfp719tm1b(EUCOMM)Wtsi PMC4631787

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MGI Allele Allele Type Produced
Zfp7tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zfp7em1(IMPC)J Exon Deletion Mice

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