The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp7.
There are 7 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Zfp712em1(IMPC)Wtsi Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp748em1(IMPC)Wtsi Zfp763em1(IMPC)Wtsi Zfp791tm1a(KOMP)Wtsi||PMC7263671|
|High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.||Nature immunology (December 2019)||Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp763em1(IMPC)Wtsi Zfp791tm1a(KOMP)Wtsi||PMC7338221|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp748em1(IMPC)Wtsi Zfp748em1(IMPC)Wtsi Zfp763em2Wtsi Zfp791tm1a(KOMP)Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp763em1Wtsi Zfp791tm1a(KOMP)Wtsi||PMC6459510|
|A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.||Nature communications (October 2017)||Zfp719tm1b(EUCOMM)Wtsi||PMC5638796|
|Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.||Scientific data (September 2017)||Zfp719tm1a(EUCOMM)Wtsi Zfp719tm1b(EUCOMM)Wtsi Zfp763em2Wtsi Zfp791tm1a(KOMP)Wtsi||PMC5827107|
|A gene expression resource generated by genome-wide lacZ profiling in the mouse.||Disease models & mechanisms (August 2015)||Zfp719tm1b(EUCOMM)Wtsi||PMC4631787|
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|MGI Allele||Allele Type||Produced|
|Zfp7tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|