Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
zinc finger protein 1
Synonyms:
Zfp-1,  mkr-1,  Fnp-1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zfp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp1.

There are 12 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Zfp182tm1a(KOMP)Wtsi Zfp182tm1b(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Zfp182tm1b(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Zfp106tm1a(KOMP)Wtsi Zfp106tm1a(KOMP)Wtsi Zfp182tm1a(KOMP)Wtsi Zfp182tm1b(KOMP)Wtsi Zfp184tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Zfp106tm1a(KOMP)Wtsi Zfp182tm1a(KOMP)Wtsi Zfp182tm1b(KOMP)Wtsi Zfp184tm1a(KOMP)Wtsi PMC6459510
WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proceedings of the National Academy of Sciences of the United States of America (October 2017) Zfp106tm1a(KOMP)Wtsi PMC5676932
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Zfp182tm1b(KOMP)Wtsi Zfp182tm1a(KOMP)Wtsi PMC5827107
Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. eLife (January 2017) Zfp106tm1a(KOMP)Wtsi PMC5283830
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proceedings of the National Academy of Sciences of the United States of America (July 2016) Zfp106tm1a(KOMP)Wtsi PMC4978283
Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration. Human molecular genetics (November 2015) Zfp106tm1a(KOMP)Wtsi PMC4706115
Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology (January 2015) Zfp106tm1a(KOMP)Wtsi PMC4399322
Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mammalian genome : official journal of the International Mammalian Genome Society (August 2013) Zfp106tm1a(KOMP)Wtsi PMC3745610
The mouse genetics toolkit: revealing function and mechanism. Genome biology (June 2011) Zfp106tm1a(KOMP)Wtsi PMC3218837

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Zfp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zfp1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zfp1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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