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Gene: Xbp1

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Name
X-box binding protein 1
MGI ID
MGI:98970
Synonyms
XBP-1 TREB-5 TREB5 D11Ertd39e
Viability
Data available
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (12) Measurements chart (299) All data table (837)
Expression & images (67) Disease models (0) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased mean corpuscular volume Xbp1tm1b(EUCOMM)Wtsi HET Early adult 8.76×10-07
increased total body fat amount Xbp1tm1a(EUCOMM)Wtsi HET Early adult 7.72×10-05
preweaning lethality, complete penetrance Xbp1tm1b(EUCOMM)Wtsi HOM   Early adult 0.00
increased circulating free fatty acids level Xbp1tm1a(EUCOMM)Wtsi HET Early adult 3.55×10-05
decreased circulating potassium level Xbp1tm1a(EUCOMM)Wtsi HET Early adult 9.34×10-05
cataract Xbp1tm1a(EUCOMM)Wtsi HET   Early adult 1.27×10-05
preweaning lethality, complete penetrance Xbp1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased monocyte cell number Xbp1tm1b(EUCOMM)Wtsi HET Early adult 2.70×10-05
decreased red blood cell distribution width Xbp1tm1b(EUCOMM)Wtsi HET Early adult 2.04×10-09
impaired glucose tolerance Xbp1tm1b(EUCOMM)Wtsi HET Early adult 7.90×10-05
abnormal vertebral arch morphology Xbp1tm1a(EUCOMM)Wtsi HET   Early adult 1.02×10-07
abnormal lens morphology Xbp1tm1a(EUCOMM)Wtsi HET   Early adult 1.27×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583) N/A
Bone 2 No N/A
Brain 2 No  (4/583) N/A
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Esophagus 2 No  (7/407) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/583) N/A
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583)  Wholemount images
Large intestine 2 No  (10/583) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/583) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563) N/A
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583) N/A
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (1/2) N/A
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583) N/A
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
postnatal mouse (1)
Kidney ambiguous
MA:0000368
trunk (1)
Kidney ambiguous
MA:0000368
urinary system (1)
Kidney ambiguous
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505) N/A
2  (1/505) N/A
2  (1/506) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (5/505) N/A
2  (1/505) N/A
2  (6/505) N/A
2  (1/505) N/A
2  (1/503) N/A
2  (1/503) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/503) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A

 Associated Images

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X-ray: XRay Images Skull Dorso Ventral Orientation
24 Images
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X-ray: XRay Images Skull Lateral Orientation
13 Images
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X-ray: XRay Images Whole Body Dorso Ventral
26 Images
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X-ray: XRay Images Whole Body Lateral Orientation
25 Images
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Echo: M-Mode Images
32 Images
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X-ray: XRay Images Forepaw
12 Images
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Embryo LacZ: LacZ images wholemount
8 Images
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Adult LacZ: LacZ Images Wholemount
1 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Xbp1tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Xbp1tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Xbp1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Xbp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Xbp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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