Genes Phenotypes

Gene: Xbp1

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Name
X-box binding protein 1
MGI ID
MGI:98970
Synonyms
TREB-5 TREB5 D11Ertd39e XBP-1
Viability
Homozygous - Lethal
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (17) Measurements chart (681) All data table (1447)
Expression & images (67) Disease models (0) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Xbp1tm1a(EUCOMM)Wtsi HET postnatal 3.67×10-05
decreased T cell number Xbp1tm1a(EUCOMM)Wtsi HET postnatal 5.13×10-05
preweaning lethality, complete penetrance Xbp1tm1a(EUCOMM)Wtsi HOM n/a 0.00
persistence of hyaloid vascular system Xbp1tm1b(EUCOMM)Wtsi HET postnatal 4.72×10-05
cataract Xbp1tm1a(EUCOMM)Wtsi HET postnatal 1.10×10-05
abnormal bone structure Xbp1tm1a(EUCOMM)Wtsi HET postnatal 4.97×10-05
decreased circulating cholesterol level Xbp1tm1a(EUCOMM)Wtsi HET postnatal 5.26×10-05
abnormal urination Xbp1tm1a(EUCOMM)Wtsi HET postnatal 3.26×10-06
preweaning lethality, complete penetrance Xbp1tm1b(EUCOMM)Wtsi HOM n/a 0.00
increased mean corpuscular volume Xbp1tm1b(EUCOMM)Wtsi HET postnatal 3.84×10-05
abnormal bone mineralization Xbp1tm1a(EUCOMM)Wtsi HET postnatal 8.14×10-08
abnormal vertebral arch morphology Xbp1tm1a(EUCOMM)Wtsi HET postnatal 1.17×10-07
increased grip strength Xbp1tm1a(EUCOMM)Wtsi HET postnatal 7.68×10-07
decreased IgG1 level Xbp1tm1a(EUCOMM)Wtsi HET postnatal 4.21×10-05
abnormal lens morphology Xbp1tm1a(EUCOMM)Wtsi HET postnatal 1.10×10-05
decreased circulating triglyceride level Xbp1tm1a(EUCOMM)Wtsi HET postnatal 6.88×10-05
vertebral fusion Xbp1tm1a(EUCOMM)Wtsi HET postnatal 3.68×10-21

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (1/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
postnatal mouse (1)
Kidney ambiguous
MA:0000368
trunk (1)
Kidney ambiguous
MA:0000368
urinary system (1)
Kidney ambiguous
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
51 Images
X-ray: XRay Images Forepaw
12 Images
X-ray: XRay Images Lateral Orientation
38 Images
X-ray: XRay Images Skull Lateral Orientation
13 Images
Echo: M-Mode Images
32 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
24 Images
Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Xbp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Xbp1tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Xbp1tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Xbp1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Xbp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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