Gene Summary

Name:
ubiquitin C
Synonyms:
2700054O04Rik

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal neural tube closure Ubcem1(IMPC)Mbp HET E9.5 0.00
preweaning lethality, complete penetrance Ubcem1(IMPC)Mbp HOM   Early adult 0.00
abnormal neural tube morphology Ubcem1(IMPC)Mbp HET E9.5 0.00
abnormal neural tube morphology Ubcem1(IMPC)Mbp HOM E9.5 0.00
prenatal lethality prior to heart atrial septation Ubcem1(IMPC)Mbp HOM   E15.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Ubc mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ubc by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Craniorachischisis
Sirenomelia, Anencephaly, Myelomeningocele, Cervical spina bifida, Spinal dysraphism ORPHA:63260
Aplasia Cutis Congenita
Spinal dysraphism ORPHA:1114
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Alg3-Cdg
Neural tube defect ORPHA:79321
Posterior Meningocele
Meningocele, Occipital meningocele, Neural tube defect, Hydrocephalus, Lipomyelomeningocele ORPHA:268810
Fanconi Anemia, Complementation Group C
Neutropenia, Intrauterine growth retardation, Leukemia, Anemia, Prolonged G2 phase of cell cycle,... OMIM:227645
Aminopterin/Methotrexate Embryofetopathy
Meningocele, Anencephaly, Holoprosencephaly, Hydrocephalus, Spinal dysraphism ORPHA:1908
Fanconi Anemia, Complementation Group E
Neutropenia, Leukemia, Anemia, Prolonged G2 phase of cell cycle, Reticulocytopenia, Pancytopenia,... OMIM:600901
Fanconi Anemia, Complementation Group A
Neutropenia, Leukemia, Anemia, Prolonged G2 phase of cell cycle, Reticulocytopenia, Pancytopenia,... OMIM:227650
Fanconi Anemia, Complementation Group D2
Neutropenia, Annular pancreas, Leukemia, Anemia, Patent ductus arteriosus, Prolonged G2 phase of ... OMIM:227646
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi
Spinal dysraphism OMIM:612918
Iniencephaly
Anencephaly, Myelomeningocele, Holoprosencephaly, Spina bifida, Hydrocephalus, Spinal dysraphism ORPHA:63259
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Spinal dysraphism OMIM:617660
Schinzel-Giedion Syndrome
Umbilical hernia, Neural tube defect ORPHA:798
Semilobar Holoprosencephaly
Hydrocephalus, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Hydrocephalus, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Neural tube defect ORPHA:93924

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ubc

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ubc.

No publications found that use IMPC mice or data for Ubc.

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MGI Allele Allele Type Produced
Ubcem1(IMPC)Mbp Whole-gene deletion Mice, Tissue

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