Gene Summary

Name:
transthyretin
Synonyms:
prealbumin

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased locomotor activity Ttrem1(IMPC)H HOM   Early adult 6.85×10-05

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ttr mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ttr by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Carpal Tunnel Syndrome 1
Reduced circulating vitamin B6 circulating OMIM:115430
Amyloidosis, Hereditary, Transthyretin-Related
Amyloidosis OMIM:105210
Attrv122I Amyloidosis
Cardiac amyloidosis ORPHA:85451
Hyperthyroxinemia, Dystransthyretinemic
Euthyroid hyperthyroxinemia OMIM:145680
Attrv30M Amyloidosis
ORPHA:85447

The table below shows human diseases predicted to be associated to Ttr by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Plasma Fibronectin Deficiency
Reduced circulating fibronectin level OMIM:614101
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration ORPHA:206599
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Hypoalphalipoproteinemia, Primary, 2, Intermediate
Decreased HDL cholesterol concentration, Decreased circulating apolipoprotein A-I concentration OMIM:619836
Amyloidosis, Cutaneous Bullous
Amyloidosis OMIM:204900
Amyloidosis, Primary Localized Cutaneous, 2
Cutaneous amyloidosis OMIM:613955
Myeloma, Multiple
Amyloidosis OMIM:254500
Tumoral Calcinosis, Normophosphatemic, Familial
Abnormal blood phosphate concentration, Abnormality of vitamin D metabolism, Decreased circulatin... OMIM:610455
Hypercarotenemia And Vitamin A Deficiency, Autosomal Dominant
Reduced circulating vitamin A concentration, Increased circulating beta-carotene concentration OMIM:115300
Amyloidosis Of Gingiva And Conjunctiva With Impaired Intellectual Development
Amyloidosis OMIM:204850
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Amyloidosis, Primary Localized Cutaneous, 1
Cutaneous amyloidosis OMIM:105250
Cerebral Amyloid Angiopathy, Cst3-Related
Generalized amyloid deposition OMIM:105150
Variant Abeta2M Amyloidosis
Cutaneous amyloidosis, Amyloidosis of peripheral nerves, Cardiac amyloidosis, Renal amyloidosis, ... ORPHA:314652
Bile Acid Malabsorption, Primary, 2
Decreased circulating vitamin D concentration, Reduced circulating vitamin A concentration, Decre... OMIM:619481
Vitamin D-Dependent Rickets, Type 3
Elevated circulating parathyroid hormone level, Hypocalcemia, Low serum calcitriol, Hypophosphate... OMIM:619073
Acys Amyloidosis
Amyloidosis, Cerebral amyloid angiopathy ORPHA:100008
Amyloidosis, Familial Visceral
Generalized amyloid deposition, Renal amyloidosis OMIM:105200
Hypercholanemia, Familial, 2
Decreased circulating vitamin D concentration, Increased serum bile acid concentration, Unconjuga... OMIM:619256
Hypobetalipoproteinemia, Familial, 1
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Decreased circulating vitamin E co... OMIM:615558
Amyloidosis, Finnish Type
Cardiac amyloidosis, Renal glomerular amyloid deposition, Generalized amyloid deposition, Optic n... OMIM:105120
Intellectual Developmental Disorder, X-Linked 110
Bradykinesia OMIM:301095
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Hypertriglyceridemia, Increased LDL cholesterol concentration, Abnormal circulating vitamin E con... ORPHA:209902
Maternal Uniparental Disomy Of Chromosome 4
Diabetes insipidus, Elevated circulating creatine kinase concentration, Abetalipoproteinemia, Hyp... ORPHA:96180
Hypercarotenemia And Vitamin A Deficiency, Autosomal Recessive
Reduced circulating vitamin A concentration OMIM:277350
Carpal Tunnel Syndrome 1
Reduced circulating vitamin B6 circulating OMIM:115430
Alpha-Fetoprotein, Hereditary Persistence Of
Elevated circulating alpha-fetoprotein concentration OMIM:615970
Palmoplantar Carcinoma, Multiple Self-Healing
Amyloidosis, Cutaneous macular amyloidosis OMIM:615225
Aa Amyloidosis
Amyloidosis, Renal amyloidosis ORPHA:85445
Hemochromatosis, Type 5
Abnormal circulating transferrin concentration, Abnormal circulating ceruloplasmin concentration,... OMIM:615517
Idiopathic Trachyonychia
Amyloidosis ORPHA:79153
Obesity Due To Sim1 Deficiency
Hyperinsulinemia, Decreased circulating vitamin B1 concentration ORPHA:369873
Duodenal Ulcer Due To Antral G-Cell Hyperfunction
Hyperpepsinogenemia I, Hypergastrinemia OMIM:126840
Abetalipoproteinemia
Decreased HDL cholesterol concentration, Hypotriglyceridemia, Hyperbilirubinemia, Abnormal circul... ORPHA:14
Formiminoglutamic Aciduria
Abnormal circulating histidine concentration, Increased blood folate concentration, Abnormality o... ORPHA:51208
Aapoaiv Amyloidosis
Cardiac amyloidosis, Renal interstitial amyloid deposits, Cutaneous amyloidosis, Renal amyloidosis ORPHA:439232
Duodenal Ulcer, Hyperpepsinogenemic I
Hyperpepsinogenemia I OMIM:126850
Hereditary Hypophosphatemic Rickets With Hypercalciuria
Increased circulating osteocalcin level, Hypophosphatemic rickets, Increased circulating beta-C-t... ORPHA:157215
Periodic Fever, Familial, Autosomal Dominant
Hepatic amyloidosis, AA amyloidosis OMIM:142680
Amyloidosis, Hereditary, Transthyretin-Related
Amyloidosis OMIM:105210
Diamond-Blackfan Anemia 9
Decreased circulating vitamin D concentration OMIM:613308
Shwachman-Diamond Syndrome
Decreased response to growth hormone stimulation test, Increased serum bile acid concentration, H... ORPHA:811
Imerslund-Grasbeck Syndrome 1
Malabsorption of Vitamin B12, Abnormal blood folate concentration, Decreased circulating vitamin ... OMIM:261100
Optic Nerve Hypoplasia, Bilateral
Optic nerve hypoplasia, Optic nerve aplasia, Remnants of the hyaloid vascular system OMIM:165550
Pancreatic Triacylglycerol Lipase Deficiency
Decreased circulating vitamin K concentration, Decreased circulating vitamin D concentration, Red... ORPHA:309031
Intrinsic Factor Deficiency
Malabsorption of Vitamin B12, Reduced haptoglobin level, Decreased circulating vitamin B12 concen... OMIM:261000
Primary Sclerosing Cholangitis
Thyroiditis, Decreased circulating vitamin E concentration, Decreased circulating vitamin K conce... ORPHA:171
Pomgnt2-Related Limb-Girdle Muscular Dystrophy R24
Decreased circulating vitamin K concentration, Elevated circulating creatine kinase concentration ORPHA:565899
Riboflavin Deficiency
Elevated circulating acylcarnitine concentration, Decreased circulating vitamin B2 concentration OMIM:615026
Pernicious Anemia
Malabsorption of Vitamin B12 OMIM:170900
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Elevated circulating parathyroid hormone level, Parathyroid hyperplasia, Hypercalcemia, Hyperphos... OMIM:617994
Dietary Iron Overload Disease
Abnormal adrenal morphology, Increased circulating ferritin concentration, Decreased circulating ... ORPHA:139507
Hypercholanemia, Familial 1
Decreased circulating vitamin K concentration, Increased serum bile acid concentration OMIM:607748
Secondary Short Bowel Syndrome
Primary hypothyroidism, Central hypothyroidism, Abnormal blood ion concentration, Low plasma citr... ORPHA:95427
Systemic Mastocytosis With Associated Hematologic Neoplasm
Amyloidosis ORPHA:98849
Liver Disease, Severe Congenital
Hypocalcemia, Hyperbilirubinemia, Hypoproteinemia, Hyperalaninemia, Abnormal circulating thyroid ... OMIM:619991
Primary Intestinal Lymphangiectasia
Hypocalcemia, Hypoproteinemia, Decreased circulating vitamin D concentration, Hypomagnesemia, Hyp... ORPHA:90362
Familial Mediterranean Fever
Amyloidosis, Renal amyloidosis OMIM:249100
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Remnants of the hyaloid vascular system ORPHA:231736
Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked
Cutaneous amyloidosis OMIM:301220
Rajab Interstitial Lung Disease With Brain Calcifications 1
Hypocalcemia, Unconjugated hyperbilirubinemia, Decreased circulating vitamin D concentration, Red... OMIM:613658
Fanconi Renotubular Syndrome 2
Elevated circulating parathyroid hormone level, Hypophosphatemia, High serum calcitriol OMIM:613388
Q Fever
Amyloidosis ORPHA:781
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Hypophosphatemic rickets, High serum calcifediol, Abnormal circulating calcium concentration, Hyp... OMIM:241530
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Elevated circulating parathyroid hormone level, High serum calcitriol OMIM:600785
Congenital Bile Acid Synthesis Defect Type 4
Elevated circulating creatine kinase concentration, Decreased circulating vitamin K concentration... ORPHA:79095
Autosomal Recessive Polycystic Kidney Disease
Increased serum bile acid concentration, Decreased circulating vitamin E concentration, Hyponatre... ORPHA:731
Congenital Bile Acid Synthesis Defect Type 3
Hyperbilirubinemia, Abnormality of vitamin metabolism ORPHA:79302
Bile Acid Synthesis Defect, Congenital, 6
Decreased circulating vitamin D concentration, Hypolipidemia OMIM:617308
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Elevated circulating parathyroid hormone level, Hypocalcemic seizures, Hypocalcemia, Low serum ca... OMIM:264700
Deafness-Hypogonadism Syndrome
Delayed puberty, Decreased circulating vitamin B1 concentration, Hypergonadotropic hypogonadism ORPHA:90646
Oculopalatocerebral Syndrome
Remnants of the hyaloid vascular system OMIM:257910
Lead Poisoning
Delayed puberty, Decreased HDL cholesterol concentration, Abnormality of vitamin D metabolism, In... ORPHA:330015
Classic Galactosemia
Delayed puberty, Decreased circulating vitamin D concentration, Decreased serum insulin-like grow... ORPHA:79239
Folate Malabsorption, Hereditary
Reduced blood folate concentration, Impaired folate absorption OMIM:229050
Megaloblastic Anemia, Folate-Responsive
Hyperbilirubinemia, Increased circulating ferritin concentration, Decreased circulating vitamin B... OMIM:601775
Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type
Decreased circulating methylcobalamin concentration, Hyperhomocystinemia, Abnormal circulating vi... OMIM:250940
Bile Acid Synthesis Defect, Congenital, 4
Hyperbilirubinemia, Decreased serum bile acid concentration, Decreased circulating calcifediol co... OMIM:214950
Congenital Disorder Of Glycosylation, Type Iit
Decreased HDL cholesterol concentration, Abnormal protein O-linked glycosylation, Hypotriglycerid... OMIM:618885
Alpha-Fetoprotein Deficiency
Decreased circulating alpha-fetoprotein concentration OMIM:615969
Generalized Eruptive Histiocytosis
Abnormal circulating vitamin B12 concentration ORPHA:157991
Osteoporosis-Pseudoglioma Syndrome
Low serum calcitriol, Isosexual precocious puberty ORPHA:2788
Celiac Disease, Susceptibility To, 1
Delayed puberty, Hypocalcemia, Thyroiditis, Decreased circulating vitamin B12 concentration, Decr... OMIM:212750
Familial Mediterranean Fever
Amyloidosis ORPHA:342
Vitamin D-Dependent Rickets, Type 2A
Elevated circulating parathyroid hormone level, Hypocalcemic seizures, Hypophosphatemia, Secondar... OMIM:277440
Refractory Celiac Disease
Hypocalcemia, Low serum calcitriol, Hypoproteinemia, Hypomagnesemia, Hypophosphatemia, Hypoalbumi... ORPHA:398063
Alkaptonuria
Amyloidosis ORPHA:56
Immunodeficiency 114, Folate-Responsive
Hypertriglyceridemia, Increased circulating ferritin concentration, Abnormal blood folate concent... OMIM:620603
Microphthalmia/Coloboma 12
Optic disc coloboma, Optic nerve aplasia, Remnants of the hyaloid vascular system OMIM:120200
Chylomicron Retention Disease
Hypocholesterolemia, Abnormality of vitamin metabolism ORPHA:71
Maxillonasal Dysplasia
Decreased circulating vitamin K concentration ORPHA:1248
Multiple Endocrine Neoplasia, Type Iia
Cutaneous lichen amyloidosis OMIM:171400
Growth Delay-Intellectual Disability-Hepatopathy Syndrome
Diabetes mellitus, Abnormality of vitamin D metabolism, Decreased serum zinc ORPHA:541423
Autosomal Dominant Hypophosphatemic Rickets
Hypocalcemia, Decreased circulating vitamin D concentration, Hypophosphatemia ORPHA:89937
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1
Calcinosis, Hypercalcemia, Hyperphosphatemia, High serum calcitriol, Hyperparathyroidism OMIM:211900
Hyperprolinemia Type 2
Reduced circulating vitamin B6 circulating, Hyperglycinemia, Hyperalaninemia, Hyperprolinemia ORPHA:79101
Methylmalonic Aciduria, Cblb Type
Elevated circulating methylmalonylcarnitine concentration, Methylmalonic acidemia, Abnormal circu... OMIM:251110
Hypocalcemic Vitamin D-Dependent Rickets
Elevated circulating parathyroid hormone level, Hypocalcemic seizures, Hypocalcemia, Low serum ca... ORPHA:289157
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Hypocalcemia, Hypophosphatemia, Decreased circulating calcifediol concentration OMIM:600081
Congenital Bile Acid Synthesis Defect Type 2
Hyperbilirubinemia, Abnormal serum bile acid concentration, Conjugated hyperbilirubinemia, Decrea... ORPHA:79303
Infantile Nephropathic Cystinosis
Abnormality of thyroid physiology, Abnormality of vitamin D metabolism, Hypokalemia, Hypophosphat... ORPHA:411629
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Delayed puberty, Decreased circulating carnitine concentration, Decreased circulating vitamin D c... ORPHA:89842
Familial Mediterranean Fever, Autosomal Dominant
Renal amyloidosis OMIM:134610
Ataxia With Vitamin E Deficiency
Hypertriglyceridemia, Increased LDL cholesterol concentration, Hypercholesterolemia, Decreased ci... OMIM:277460
Marchiafava-Bignami Disease
Decreased circulating vitamin B1 concentration ORPHA:221074
Familial Cold Autoinflammatory Syndrome 1
Renal amyloidosis OMIM:120100
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Abnormal circulating vitamin B12 concentration, Hyperammonemia, Methylmalonic acidemia, Hyperglyc... OMIM:251000
Muckle-Wells Syndrome
Optic atrophy, Renal amyloidosis ORPHA:575
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Decreased CSF 5-methyltetrahydrofolate concentration, Abnormal blood folate concentration OMIM:613839
Inherited Creutzfeldt-Jakob Disease
Amyloidosis of peripheral nerves ORPHA:282166
Muckle-Wells Syndrome
Renal amyloidosis OMIM:191900
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Increased total iron binding capacity, Abnormal blood inorganic cation concentration, Abnormal tr... ORPHA:309854
Methylmalonic Aciduria, Cbla Type
Methylmalonic acidemia, Abnormal circulating vitamin B12 concentration, Hyperammonemia, Decreased... OMIM:251100
Persistent Hyperplastic Primary Vitreous
Hyaloid vascular remnant and retrolental mass, Tractional retinal detachment, Remnants of the hya... ORPHA:91495
Juvenile Nephropathic Cystinosis
Hypokalemia, Hypocalcemia, Hypouricemia, Hypothyroidism, Hyponatremia, Decreased circulating vita... ORPHA:411634
Hypophosphatemic Rickets, X-Linked Recessive
High serum calcitriol, Hypophosphatemic rickets, Hypophosphatemia OMIM:300554
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Delayed puberty, Decreased circulating vitamin D concentration, Decreased serum zinc, Abnormal ci... ORPHA:79408
Rnf13-Related Severe Early-Onset Epileptic Encephalopathy
Abnormal circulating vitamin B12 concentration ORPHA:544503
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Retinal detachment, Optic nerve hypoplasia, Remnants of the hyaloid vascular system, Retinal dysp... OMIM:614643
Multiple Endocrine Neoplasia Type 2
Cutaneous lichen amyloidosis ORPHA:653
Hypomagnesemia 3, Renal
Elevated circulating parathyroid hormone level, Hypocalcemic seizures, Increased circulating beta... OMIM:248250
Oculo-Palato-Cerebral Syndrome
Retinal detachment, Remnants of the hyaloid vascular system ORPHA:2714
Dent Disease 1
High serum calcitriol, Hypophosphatemia OMIM:300009
Multiple Myeloma
Elevated circulating creatinine concentration, Hypercalcemia, Abnormality of vitamin B12 metaboli... ORPHA:29073
Autosomal Recessive Hypophosphatemic Rickets
Low serum calcitriol, Renal hypophosphatemia, Hypophosphatemic rickets, Abnormality of vitamin D ... ORPHA:289176
Imerslund-Gräsbeck Syndrome
Abnormal blood 5-methyltetrahydrofolate level, Malabsorption of Vitamin B12, Decreased circulatin... ORPHA:35858
Transcobalamin Ii Deficiency
Abnormal circulating vitamin B12 concentration, Abnormal blood folate concentration, Hyperhomocys... OMIM:275350
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Methylmalonic acidemia, Decreased circulating methylcobalamin concentration, Hyperhomocystinemia,... OMIM:277400
Pyruvate Dehydrogenase E2 Deficiency
Decreased circulating vitamin B1 concentration ORPHA:79244
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Delayed puberty, Hypertriglyceridemia, Hyperuricemia, Thyroiditis, Hyperlipidemia, Hypothyroidism... ORPHA:79259
Bone Marrow Failure Syndrome 3
Decreased circulating vitamin D concentration, Decreased circulating vitamin E concentration OMIM:617052
Diamond-Blackfan Anemia 7
Decreased circulating vitamin D concentration OMIM:612562
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Retinal nonattachment, Remnants of the hyaloid vascular system OMIM:221900
Oculocerebrorenal Syndrome Of Lowe
Delayed puberty, Abnormal circulating calcium-phosphate regulating hormone concentration, Hypokal... ORPHA:534
Dent Disease
Renal hypophosphatemia, Elevated circulating creatine kinase concentration, High serum calcitriol ORPHA:1652
Epidermal Nevus Syndrome
Decreased circulating vitamin D concentration ORPHA:35125
Attrv122I Amyloidosis
Cardiac amyloidosis ORPHA:85451
Eiken Syndrome
Decreased circulating vitamin D concentration OMIM:600002
Pearson Syndrome
Decreased response to growth hormone stimulation test, Hypoparathyroidism, Hypokalemia, Hypocalce... ORPHA:699
Atelis Syndrome 2
Remnants of the hyaloid vascular system OMIM:620185
Chondrodysplasia Punctata, Autosomal Dominant
Decreased circulating vitamin K concentration OMIM:118650
Mucopolysaccharidosis Type 3
Decreased circulating vitamin D concentration ORPHA:581
Congenital Erythropoietic Porphyria
Increased erythrocyte protoporphyrin concentration, Reduced haptoglobin level, Unconjugated hyper... ORPHA:79277
Pierson Syndrome
Retinal detachment, Remnants of the hyaloid vascular system, Retinal hemorrhage OMIM:609049
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Abnormality of the endocrine system, Hypothyroidism, Precocious puberty, Decreased circulating vi... ORPHA:438213
Acromelic Frontonasal Dysostosis
Optic nerve hypoplasia, Remnants of the hyaloid vascular system OMIM:603671
Autoimmune Lymphoproliferative Syndrome
Abnormal circulating vitamin B12 concentration, Thyroiditis, Thyroid carcinoma, Thyroid adenoma ORPHA:3261
Full Nf2-Related Schwannomatosis
Remnants of the hyaloid vascular system ORPHA:637
Microphthalmia, Syndromic 2
Retinal detachment, Remnants of the hyaloid vascular system OMIM:300166
Autosomal Dominant Cutis Laxa
Decreased circulating vitamin D concentration ORPHA:90348
Lysinuric Protein Intolerance
Hepatic amyloidosis, Renal amyloidosis ORPHA:470
Norrie Disease
Optic atrophy, Retinal detachment, Remnants of the hyaloid vascular system ORPHA:649
Neuroocular Syndrome
Remnants of the hyaloid vascular system OMIM:619539
Holoprosencephaly 2
Remnants of the hyaloid vascular system OMIM:157170
Hyperthyroxinemia, Dystransthyretinemic
Euthyroid hyperthyroxinemia OMIM:145680
Attrv30M Amyloidosis
ORPHA:85447

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ttr

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ttr.

No publications found that use IMPC mice or data for Ttr.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ttrtm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ttrem2(IMPC)H Indel Mice
Ttrtm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ttrem1(IMPC)H Indel Mice
Ttrtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ttrtm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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