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Gene: Trp53

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Name
transformation related protein 53
MGI ID
MGI:98834
Synonyms
p53 p44
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (6) Measurements chart (218) All data table (614)
Expression & images (46) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal retina morphology Trp53tm1b(EUCOMM)Hmgu HOM   Early adult 1.94×10-07
increased large unstained cell number Trp53tm1b(EUCOMM)Hmgu HOM   Early adult 6.74×10-05
increased startle reflex Trp53tm1b(EUCOMM)Hmgu HOM Early adult 6.97×10-05
persistence of hyaloid vascular system Trp53tm1b(EUCOMM)Hmgu HOM Early adult 1.83×10-06
increased blood urea nitrogen level Trp53tm1b(EUCOMM)Hmgu HOM   Early adult 1.87×10-10
preweaning lethality, incomplete penetrance Trp53tm1b(EUCOMM)Hmgu HOM   Early adult 0.00

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Select physiological systems to view:
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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/590)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/590)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590)  (2/2)  Wholemount images
Hippocampus 2 No  (3/590)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/590)  (1/2)  Wholemount images
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590)  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/590)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/590)  (2/2) N/A
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/590)  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/590)  (2/2)  Wholemount images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590)  (2/2)  Wholemount images
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (5)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
immune system (3)
Lymph Node expression
MA:0000139
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (2)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
nervous system (5)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
MA:0000191
MA:0000169
MA:0000198
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (23)
Adrenal gland expression
MA:0000116
reproductive system (2)
Ovary expression
Oviduct expression
Uterus expression
MA:0000384
MA:0000389
MA:0000385
respiratory system (3)
Lung expression
MA:0000415
set of connective tissues (1)
Cartilage tissue expression
Bone expression
MA:0000104
MA:0001459
trunk (13)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

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X-ray: XRay Images Whole Body Dorso Ventral
12 Images
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Adult LacZ: LacZ Images Wholemount
23 Images
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X-ray: XRay Images Whole Body Lateral Orientation
12 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Trp53tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Trp53tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells