Gene: Timp3

Name tissue inhibitor of metalloproteinase 3

Synonyms Timp-3

Status ES CellsMice
tm1.1
Mice
tm1
phenotype data available

Links MGI:98754   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Timp3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Timp3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal retinal blood vessel morphology Timp3tm1.1(KOMP)Vlcg HOM Female Male postnatal 9.05E-9
increased hematocrit Timp3tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.24E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354) (2/2)
Aorta 2 No (2/530) (2/2)
Bone marrow 2 No (2/2)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/530) (2/2)
Cerebellum 2 No (6/530) (2/2)
Cerebral cortex 2 No (6/530) (2/2)
Epididymis 2 No (1/103) (1/2)
Esophagus 2 No (1/354) (2/2)
Eye 2 No (1/530) (2/2)
Heart 2 No (4/530) (2/2)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/530)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530) (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (3/354) (2/2)
Ovary 2 No (1/530) (1/2)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530) (2/2)
Peripheral nervous system 2 No (4/530) (2/2)
Peyer's patch 2 No (1/354) (2/2)
Pituitary gland 2 No (2/530) (2/2)
Prostate gland 2 No (3/530)
Skeletal muscle 2 No (2/2)
Skin 2 No (2/530) (2/2)
Small intestine 2 No (5/530) (2/2)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530) (2/2)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530) (2/2)
Submandibular gland 2 No (2/2)
Testis 2 No (7/530) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (1/530) (2/2)
Thyroid gland 2 No (11/530) (2/2)
Trachea 2 No (5/530) (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/530) (1/2)
Vascular system 2 No (1/354) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (5/413)
Ear 1
Embryo 1 (1/1)
Eye 1
Foot 1 (1/1)
Forebrain 1
Forelimb 1 (1/1)
Hand 1 (1/1)
Head 1 (4/413) (1/1)
Heart 1 (1/1)
Hindbrain 1 (5/413)
Hindlimb 1 (1/1)
Liver 1
Lung 1 (1/1)
Mandibular process 1 (1/1)
Maxillary process 1 (1/1)
Midbrain 1
Oral cavity 1 (1/1)
Skin 1 (1/1)
Tail 1 (1/1)
Tail somite 1 (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • X-ray: XRay Images Forepaw
    11 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images
  • X-ray: XRay Images Skull Lateral Orientation
    11 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Timp3tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Timp3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Timp3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Timp3tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene