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Gene: Thy1 MGI:98747

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
thymus cell antigen 1, theta
Synonyms:
T25,  Thy1.2,  Thy-1,  Thy-1.2,  Thy1.1,  CD90,  Thy 1.2

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Thy1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Thy1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypersensitivity Pneumonitis, Familial
Hypersensitivity pneumonitis OMIM:145300
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 3
Pulmonary fibrosis, Usual interstitial pneumonia OMIM:616373
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 5
Pulmonary fibrosis OMIM:618674
Idiopathic Pulmonary Fibrosis
Bronchiectasis, Abnormal pulmonary interstitial morphology, Honeycomb lung, Pulmonary fibrosis, R... ORPHA:2032
Cystic Hamartoma Of Lung And Kidney
Recurrent respiratory infections, Pulmonary fibrosis ORPHA:2111
Pulmonary Hemosiderosis
Recurrent intrapulmonary hemorrhage, Pulmonary fibrosis OMIM:178550
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 4
Honeycomb lung, Pulmonary fibrosis OMIM:616371
Interstitial Lung Disease 2
Usual interstitial pneumonia, Alveolar cell carcinoma, Pulmonary fibrosis, Elevated bronchoalveol... OMIM:178500
Autosomal Recessive Spastic Paraplegia Type 70
Abnormal pulmonary interstitial morphology ORPHA:401835
Riddle Syndrome
Pulmonary fibrosis OMIM:611943
Retinal Dystrophy With Or Without Extraocular Anomalies
Pulmonary fibrosis OMIM:617175
Surfactant Metabolism Dysfunction, Pulmonary, 3
Nonspecific interstitial pneumonia, Crazy paving pattern, Nodular pattern on pulmonary HRCT, Desq... OMIM:610921
Chronic Beryllium Disease
Pulmonary fibrosis, Hypersensitivity pneumonitis, Lymphocytic interstitial pneumonia, Reticulonod... ORPHA:133
Sarcoidosis, Susceptibility To, 2
Pneumothorax, Bronchiectasis, Abnormal pulmonary interstitial morphology, Pleural effusion, Pulmo... OMIM:612387
Interstitial Lung Disease 1
Nonspecific interstitial pneumonia, Intralobular septal thickening, Elevated bronchoalveolar lava... OMIM:619611
Pulmonary Nodular Lymphoid Hyperplasia
Nodular pattern on pulmonary HRCT ORPHA:60026
Surfactant Metabolism Dysfunction, Pulmonary, 2
Nonspecific interstitial pneumonia, Spontaneous pneumothorax, Intralobular septal thickening, Des... OMIM:610913
Acute Interstitial Pneumonia
Peribronchovascular interstitial thickening, Nodular pattern on pulmonary HRCT, Atelectasis, Bron... ORPHA:79126
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 2
Pulmonary fibrosis OMIM:614743
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 1
Reticular pattern on pulmonary HRCT, Pulmonary fibrosis, Usual interstitial pneumonia OMIM:614742
Asbestos Intoxication
Atelectasis, Pleural thickening, Abnormal pulmonary interstitial morphology, Pulmonary fibrosis, ... ORPHA:2302
Limited Cutaneous Systemic Sclerosis
Pulmonary fibrosis ORPHA:220402
Plectin-Related Limb-Girdle Muscular Dystrophy R17
Bronchiolitis, Atelectasis, Pulmonary fibrosis ORPHA:254361
Fanconi Renotubular Syndrome 5
Emphysema, Pulmonary fibrosis, Lung adenocarcinoma OMIM:618913
Poikiloderma, Hereditary Fibrosing, With Tendon Contractures, Myopathy, And Pulmonary Fibrosis
Pulmonary fibrosis OMIM:615704
Pulmonary Fibrosis-Hepatic Hyperplasia-Bone Marrow Hypoplasia Syndrome
Pulmonary fibrosis, Abnormal pleura morphology ORPHA:210136
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Pulmonary fibrosis OMIM:611926
Idiopathic Pulmonary Hemosiderosis
Reticular pattern on pulmonary HRCT, Pulmonary fibrosis, Nodular pattern on pulmonary HRCT, Diffu... ORPHA:99931
Immunodeficiency 60 And Autoimmunity
Recurrent sinopulmonary infections, Bronchiectasis, Pulmonary fibrosis OMIM:618394
Autoimmune Interstitial Lung, Joint, And Kidney Disease
Abnormal pulmonary interstitial morphology, Hemosiderin-laden macrophages in bronchoalveolar flui... OMIM:616414
Hereditary Mucoepithelial Dysplasia
Recurrent respiratory infections, Pulmonary fibrosis ORPHA:1839
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Recurrent respiratory infections, Atelectasis, Elevated bronchoalveolar lavage fluid neutrophil p... OMIM:610978
Aspergillosis
Pneumonia, Hypersensitivity pneumonitis, Bronchiectasis, Pulmonary fibrosis, Pleural effusion, Pl... ORPHA:1163
Scedosporiosis
Pneumonia, Bronchitis, Pleural empyema, Pulmonary fibrosis, Pleuritis ORPHA:449280
Niemann-Pick Disease, Type B
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology OMIM:607616
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Recurrent respiratory infections, Recurrent pneumonia, Bronchiectasis, Pulmonary fibrosis, Recurr... OMIM:618986
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Pulmonary fibrosis ORPHA:457240
Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Pulmonary venous occlusion, Interlobular septal thickening OMIM:265450
Braddock Syndrome
Pulmonary fibrosis ORPHA:52047
Hermansky-Pudlak Syndrome 4
Pulmonary fibrosis OMIM:614073
Interstitial Pneumonitis, Desquamative, Familial
Desquamative interstitial pneumonitis, Recurrent upper respiratory tract infections, Type II pneu... OMIM:263000
Antisynthetase Syndrome
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology, Pulmonary fibrosis ORPHA:81
Felty Syndrome
Recurrent respiratory infections, Recurrent pharyngitis, Recurrent pneumonia, Pulmonary fibrosis,... ORPHA:47612
Immunodeficiency 85 And Autoimmunity
Recurrent respiratory infections, Pulmonary fibrosis OMIM:619510
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 7
Emphysema, Pulmonary fibrosis OMIM:620365
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 6
Pulmonary fibrosis OMIM:619767
Respiratory Bronchiolitis-Interstitial Lung Disease Syndrome
Respiratory tract infection, Hypersensitivity pneumonitis, Bronchiectasis, Honeycomb lung, Chroni... ORPHA:79127
Immunodeficiency 13
Recurrent upper respiratory tract infections, Bronchiolitis obliterans organizing pneumonia, Bron... OMIM:615518
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Recurrent upper respiratory tract infections, Abnormal pulmonary interstitial morphology, Recurre... OMIM:613101
Diffuse Alveolar Hemorrhage
Irregular septal thickening on pulmonary HRCT, Pulmonary fibrosis ORPHA:90060
Neonatal Acute Respiratory Distress Due To Sp-B Deficiency
Intraalveolar phospholipid accumulation, Interstitial pneumonitis, Abnormal pulmonary interstitia... ORPHA:217563
Lymphoid Interstitial Pneumonia
Multiple pulmonary cysts, Respiratory tract infection, Bronchiectasis, Subpleural interstitial th... ORPHA:79128
Bone Marrow Failure Syndrome 5
Pulmonary fibrosis OMIM:618165
Polymyositis
Abnormal pulmonary interstitial morphology, Pulmonary fibrosis ORPHA:732
46,Xx Gonadal Dysgenesis
Pulmonary fibrosis ORPHA:243
Bronchiolitis Obliterans With Obstructive Pulmonary Disease
Respiratory tract infection, Bronchiolitis obliterans, Bronchiectasis, Pneumonia ORPHA:1303
Pulmonary Alveolar Microlithiasis
Bronchitis, Respiratory tract infection, Pleural thickening, Pneumothorax, Bronchiectasis, Fatiga... ORPHA:60025
Mixed Connective Tissue Disease
Pleuritis, Pulmonary fibrosis, Abnormal pulmonary interstitial morphology ORPHA:809
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Pleural effusion, Recurrent pneumonia, Pulmonary fibrosis OMIM:618935
Sting-Associated Vasculopathy, Infantile-Onset
Recurrent respiratory infections, Pulmonary fibrosis OMIM:615934
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Recurrent respiratory infections, Recurrent aspiration pneumonia, Pulmonary fibrosis, Pulmonary h... ORPHA:79124
Immunodeficiency 91 And Hyperinflammation
Recurrent pneumonia, Abnormal pulmonary interstitial morphology, Recurrent lower respiratory trac... OMIM:619644
Chitayat Syndrome
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology OMIM:617180
Riddle Syndrome
Pneumonia, Bronchitis, Recurrent pneumonia, Abnormal pulmonary interstitial morphology, Pulmonary... ORPHA:420741
Diffuse Cutaneous Systemic Sclerosis
Pulmonary fibrosis ORPHA:220393
Interstitial Lung And Liver Disease
Intraalveolar phospholipid accumulation, Abnormal pulmonary interstitial morphology, Pulmonary fi... OMIM:615486
Brain-Lung-Thyroid Syndrome
Recurrent respiratory infections, Recurrent pneumonia, Pulmonary fibrosis, Abnormal pulmonary int... ORPHA:209905
Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis
Pulmonary fibrosis OMIM:612852
Immune-Mediated Necrotizing Myopathy
Fatiguable weakness of proximal limb muscles, Abnormal pulmonary interstitial morphology ORPHA:206569
Acute Lung Injury
Abnormal pulmonary interstitial morphology, Pneumonia, Diffuse alveolar hemorrhage ORPHA:178320
Dyskeratosis Congenita, Autosomal Recessive 1
Pulmonary fibrosis OMIM:224230
Hermansky-Pudlak Syndrome 1
Pulmonary fibrosis OMIM:203300
Dyskeratosis Congenita, Autosomal Dominant 2
Pulmonary fibrosis OMIM:613989
Surfactant Metabolism Dysfunction, Pulmonary, 1
Desquamative interstitial pneumonitis, Intraalveolar phospholipid accumulation, Absent bronchoalv... OMIM:265120
Dyskeratosis Congenita, Autosomal Dominant 3
Pulmonary fibrosis OMIM:613990
Rajab Interstitial Lung Disease With Brain Calcifications 2
Abnormal pulmonary interstitial morphology OMIM:619013
Dyskeratosis Congenita, Autosomal Dominant 1
Interstitial pneumonitis, Pulmonary fibrosis OMIM:127550
Erdheim-Chester Disease
Pleural effusion, Abnormal pulmonary interstitial morphology, Pulmonary fibrosis ORPHA:35687
Wild Type Attr Amyloidosis
Pleural effusion, Abnormal pulmonary interstitial morphology, Pulmonary edema ORPHA:330001
Typhoid
Abnormal pulmonary interstitial morphology ORPHA:99745
Congenital Myopathy 21 With Early Respiratory Failure
Lipoid pneumonia OMIM:620326
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Bronchiolitis obliterans OMIM:617241
Systemic Sclerosis
Abnormal pulmonary interstitial morphology, Pulmonary fibrosis ORPHA:90291
Hermansky-Pudlak Syndrome 2
Recurrent pneumonia, Pulmonary fibrosis OMIM:608233
Niemann-Pick Disease, Type C2
Pulmonary fibrosis OMIM:607625
Cerebroretinal Microangiopathy With Calcifications And Cysts 1
Pulmonary fibrosis OMIM:612199
Surfactant Metabolism Dysfunction, Pulmonary, 5
Interlobular septal thickening, Intraalveolar phospholipid accumulation OMIM:614370
Sarcoidosis, Susceptibility To, 1
Emphysema, Bronchiectasis, Abnormal pulmonary interstitial morphology, Pulmonary fibrosis, Pleura... OMIM:181000
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Interstitial pneumonitis, Recurrent lower respiratory tract infections, Recurrent upper respirato... OMIM:615952
Juvenile Dermatomyositis
Pulmonary fibrosis ORPHA:93672
Reactive Arthritis
Pulmonary fibrosis, Abnormal pleura morphology ORPHA:29207
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Atelectasis, Recurrent respiratory infections, Pulmonary fibrosis OMIM:618278
Primary Ciliary Dyskinesia
Recurrent sinopulmonary infections, Peribronchovascular interstitial thickening, Pulmonary situs ... ORPHA:244
Idiopathic Chronic Eosinophilic Pneumonia
Atelectasis, Pleural effusion, Hypersensitivity pneumonitis ORPHA:2902
Hermansky-Pudlak Syndrome
Pulmonary fibrosis ORPHA:79430
Dermatomyositis
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology, Pulmonary fibrosis,... ORPHA:221
Granulomatosis With Polyangiitis
Recurrent respiratory infections, Pleuritis, Recurrent intrapulmonary hemorrhage, Pulmonary fibrosis ORPHA:900
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Atelectasis, Abnormal pulmonary interstitial morphology, Bronchiectasis, Recurrent lower respirat... OMIM:620233
Idiopathic Hypereosinophilic Syndrome
Pleural effusion, Pulmonary fibrosis ORPHA:3260
Hermansky-Pudlak Syndrome 10
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology OMIM:617050
Autoimmune Lymphoproliferative Syndrome
Pulmonary fibrosis ORPHA:3261
Gaucher Disease, Type I
Abnormal pulmonary interstitial morphology OMIM:230800
Gaucher Disease
Abnormal pulmonary interstitial morphology, Pulmonary fibrosis ORPHA:355
Sarcoidosis
Abnormal pleura morphology, Abnormal lung morphology, Pneumothorax, Bronchiectasis, Pleural effus... ORPHA:797
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Abnormal pulmonary interstitial morphology, Pulmonary fibrosis ORPHA:2072
Bronchial Neuroendocrine Tumor
Abnormal pulmonary interstitial morphology, Pneumonia ORPHA:97287
Al Amyloidosis
Abnormal pulmonary interstitial morphology, Pulmonary interstitial high-resolution computed tomog... ORPHA:85443
Overlap Myositis
Abnormal pulmonary interstitial morphology ORPHA:206572
Hereditary Pulmonary Alveolar Proteinosis
Acute infectious pneumonia, Crazy paving pattern ORPHA:264675
Primary Fanconi Renotubular Syndrome
Pulmonary fibrosis ORPHA:3337
Dyskeratosis Congenita, X-Linked
Pulmonary fibrosis OMIM:305000
Gaucher Disease Type 1
Abnormal pulmonary interstitial morphology ORPHA:77259
Immunodeficiency 97 With Autoinflammation
Recurrent sinopulmonary infections, Bronchiolitis obliterans organizing pneumonia OMIM:619802
Q Fever
Pleural effusion, Abnormal pulmonary interstitial morphology, Pneumonia ORPHA:781
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Pulmonary interstitial lymphocyte infiltration, Recurrent respiratory infections OMIM:606367
Knobloch Syndrome 2
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology OMIM:618458
Fusariosis
Lung abscess, Pneumonia, Hypersensitivity pneumonitis, Bronchiectasis, Pleural effusion ORPHA:228119
Gaucher Disease Type 3
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology ORPHA:77261
Agammaglobulinemia, X-Linked
Recurrent pneumonia, Bronchiectasis, Bronchiolitis obliterans, Recurrent sinusitis, Recurrent low... OMIM:300755
Primary Sjögren Syndrome
Usual interstitial pneumonia, Abnormal pulmonary interstitial morphology, Lymphocytic interstitia... ORPHA:289390
Autoimmune Polyendocrinopathy Type 4
Abnormal pulmonary interstitial morphology ORPHA:227990
Autoimmune Polyendocrinopathy Type 3
Abnormal pulmonary interstitial morphology ORPHA:227982
Rajab Interstitial Lung Disease With Brain Calcifications 1
Emphysema, Abnormal pulmonary interstitial morphology OMIM:613658
Kawasaki Disease
Recurrent pharyngitis, Abnormal pulmonary interstitial morphology ORPHA:2331
Autoimmune Pulmonary Alveolar Proteinosis
Crazy paving pattern, Intraalveolar phospholipid accumulation ORPHA:747
Kikuchi-Fujimoto Disease
Pleural effusion, Abnormal pulmonary interstitial morphology ORPHA:50918
Brucellosis
Lung abscess, Pneumonia, Bronchitis, Pulmonary granulomatosis, Pleural effusion ORPHA:1304
Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome
Recurrent respiratory infections, Abnormal pulmonary interstitial morphology OMIM:614748
Chronic Visceral Acid Sphingomyelinase Deficiency
Abnormal pulmonary interstitial morphology ORPHA:77293
Chronic Graft Versus Host Disease
Bronchiolitis obliterans, Pleural effusion, Pneumothorax, Bronchiectasis ORPHA:99921
Ehlers-Danlos Syndrome, Vascular Type
Pulmonary bulla, Recurrent intrapulmonary hemorrhage, Spontaneous pneumothorax, Repeated pneumoth... OMIM:130050
Goodpasture Syndrome
Nodular pattern on pulmonary HRCT, Hemosiderin-laden macrophages in bronchoalveolar fluid, Reticu... OMIM:233450

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Thy1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Thy1.

No publications found that use IMPC mice or data for Thy1.

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MGI Allele Allele Type Produced
Thy1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Thy1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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