Gene: Thra

Log in to follow
Name
thyroid hormone receptor alpha
MGI ID
MGI:98742
Synonyms
T3Ralpha T3R[a] Nr1a1 TR alpha 1 c-erbAalpha Erba TR alpha 2 6430529J03Rik Thra2 Thra1 Rvr
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
limb grasping Thratm1b(EUCOMM)Wtsi HET Early adult 3.30×10-06
shortened ST segment Thratm1b(EUCOMM)Wtsi HET   Late adult 3.18×10-05
hyperactivity Thratm1b(EUCOMM)Wtsi HET Early adult 7.35×10-13
decreased startle reflex Thratm1b(EUCOMM)Wtsi HET Late adult 2.45×10-19
decreased total retina thickness Thratm1b(EUCOMM)Wtsi HET Early adult 2.05×10-21
decreased circulating aspartate transaminase level Thratm1b(EUCOMM)Wtsi HET   Late adult 4.32×10-05
decreased total body fat amount Thratm1b(EUCOMM)Wtsi HET Early adult 5.98×10-07
increased blood urea nitrogen level Thratm1b(EUCOMM)Wtsi HET Late adult 1.76×10-07
abnormal contextual conditioning behavior Thratm1b(EUCOMM)Wtsi HET Early adult 1.55×10-06
abnormal tail movements Thratm1b(EUCOMM)Wtsi HET Late adult 5.67×10-07
abnormal heart left ventricle morphology Thratm1b(EUCOMM)Wtsi HET   Late adult 2.77×10-05
preweaning lethality, incomplete penetrance Thratm1b(EUCOMM)Wtsi HOM   Early adult 0.00
increased startle reflex Thratm1b(EUCOMM)Wtsi HET Early adult 3.96×10-05
abnormal body weight Thratm1b(EUCOMM)Wtsi HET Late adult 1.81×10-06
decreased exploration in new environment Thratm1b(EUCOMM)Wtsi HET   Late adult 6.78×10-05
hyperactivity Thratm1b(EUCOMM)Wtsi HET Late adult 9.31×10-09
increased bone mineral content Thratm1b(EUCOMM)Wtsi HET Early adult 3.58×10-06
shortened QT interval Thratm1b(EUCOMM)Wtsi HET   Late adult 9.11×10-05
improved glucose tolerance Thratm1b(EUCOMM)Wtsi HET Early adult 2.23×10-05
increased circulating alkaline phosphatase level Thratm1b(EUCOMM)Wtsi HET   Early adult 9.16×10-06
increased lean body mass Thratm1b(EUCOMM)Wtsi HET Late adult 9.16×10-12
abnormal contextual conditioning behavior Thratm1b(EUCOMM)Wtsi HET Late adult 1.82×10-07
decreased total body fat amount Thratm1b(EUCOMM)Wtsi HET Late adult 4.38×10-11
increased bone mineral density Thratm1b(EUCOMM)Wtsi HET   Early adult 3.41×10-05
abnormal bone structure Thratm1b(EUCOMM)Wtsi HET   Early adult 2.81×10-05
abnormal retinal inner nuclear layer morphology Thratm1b(EUCOMM)Wtsi HET   Early adult 7.74×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/556)  (2/2)  Section images
Aorta 2 No  (1/557)  (2/2)  Section images
Brain 2 No  (4/564)  (2/2)  Section images
Brainstem 2 No  (2/555)  (2/2)  Section images
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No  (1/567)  (2/2)  Section images
Cerebellum 2 No  (3/559)  (2/2)  Section images
Cerebral cortex 2 No  (2/559)  (2/2)  Section images
Epididymis 2 No  (16/127)  (1/2)  Section images
Esophagus 2 No  (7/393)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/546)  (2/2)  Section images
Hippocampus 2 No  (3/556)  (2/2)  Section images
Hypothalamus 2 No  (2/557)  (2/2)  Section images
Kidney 2 No  (21/561)  (2/2)  Section images
Large intestine 2 No  (10/556)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No  (1/555) N/A
Lung 2 No  (2/556)  (2/2)  Section images
Lymph node 2 No  (1/561)  (2/2)  Section images
Mammary gland 2 No  (1/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/552)  (2/2)  Section images
Ovary 2 No  (1/558)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/555)  (2/2)  Section images
Peripheral nervous system 2 No  (2/550)  (2/2)  Section images
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (1/565)  (2/2)  Section images
Prostate gland 2 No  (12/550) N/A
Skeletal muscle 2 No  (2/2)  Section images
Skin 2 No  (1/558)  (2/2)  Section images
Small intestine 2 No  (9/558)  (2/2)  Section images
Spinal cord 2 No  (3/552)  (2/2)  Section images
Spleen 2 No  (2/563)  (2/2)  Section images
Stomach 2 No  (12/556)  (2/2)  Section images
Striatum 2 No  (3/554)  (2/2)  Section images
Submandibular gland 2 No  (2/123)  (2/2)  Section images
Testis 2 No  (6/552)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  (1/551)  Section images
Thyroid gland 2 No  (16/554)  (2/2)  Section images
Trachea 2 No  (3/556)  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2)  Section images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (4/320)  (2/3) N/A
Dorsal root ganglion 2  (1/37) Image Only N/A
Ear 2  (1/341) Image Only N/A
Embryo 2  (1/316)  (2/3)  Wholemount images
Eye 2  (2/3) N/A
Footplate 2  (1/327)  (2/3) N/A
Forebrain 2  (2/3) N/A
Forelimb 2  (1/335)  (2/3) N/A
Fronto-nasal process 2 Image Only N/A
Handplate 2  (2/3) N/A
Head 2  (5/326)  (2/3) N/A
Heart 2  (1/333)  (2/3) N/A
Hindbrain 2  (4/330)  (2/3) N/A
Hindlimb 2  (1/329)  (2/3) N/A
Liver 2  (1/319) Image Only N/A
Lung 2  (1/350) Image Only N/A
Mandibular process 2  (1/330)  (2/3) N/A
Maxillary process 2  (1/335)  (2/3) N/A
Midbrain 2  (1/322)  (2/3) N/A
Nose 2  (2/2) N/A
Oral cavity 2 Image Only N/A
Skin 2  (2/3) N/A
Spinal cord 2  (1/48)  (2/2) N/A
Tail 2  (2/3) N/A
Tail somite group 2  (1/345)  (2/3) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
20 Images
X-ray: XRay Images Whole Body Lateral Orientation
20 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Original Image
Adult LacZ: LacZ Images Section
45 Images
X-ray: XRay Images Forepaw
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
7 Images
Immunophenotyping: Panel A FCS file(s)
6 Images
Immunophenotyping: Panel B FCS file(s)
6 Images

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Thratm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Thratm357(L1L2_gt2) Targeting vectors
Thratm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Thratm43807(L1L2_gt1) Targeting vectors
Thratm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells