Gene: Thra

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Name
thyroid hormone receptor alpha
MGI ID
MGI:98742
Synonyms
Nr1a1 T3R[a] T3Ralpha TR alpha 1 c-erbAalpha Erba TR alpha 2 6430529J03Rik Thra1 Thra2 Rvr
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased mean corpuscular hemoglobin Thratm1b(EUCOMM)Wtsi HET   Early adult 6.72×10-05
increased lean body mass Thratm1b(EUCOMM)Wtsi HET Late adult 4.95×10-12
increased bone mineral density Thratm1b(EUCOMM)Wtsi HET Early adult 2.44×10-06
abnormal bone structure Thratm1b(EUCOMM)Wtsi HET   Early adult 1.78×10-07
decreased total body fat amount Thratm1b(EUCOMM)Wtsi HET Early adult 5.22×10-09
abnormal retinal inner nuclear layer morphology Thratm1b(EUCOMM)Wtsi HET   Early adult 7.88×10-06
abnormal contextual conditioning behavior Thratm1b(EUCOMM)Wtsi HET Early adult 1.55×10-06
increased circulating alkaline phosphatase level Thratm1b(EUCOMM)Wtsi HET   Early adult 6.90×10-06
increased lean body mass Thratm1b(EUCOMM)Wtsi HET   Early adult 7.59×10-05
decreased total body fat amount Thratm1b(EUCOMM)Wtsi HET Late adult 2.36×10-11
increased startle reflex Thratm1b(EUCOMM)Wtsi HET Early adult 5.78×10-05
abnormal embryo size Thratm1b(EUCOMM)Wtsi HET E18.5 0.00
decreased startle reflex Thratm1b(EUCOMM)Wtsi HET Late adult 2.45×10-19
limb grasping Thratm1b(EUCOMM)Wtsi HET Early adult 7.66×10-06
preweaning lethality, incomplete penetrance Thratm1b(EUCOMM)Wtsi HOM   Early adult 0.00
abnormal tail movements Thratm1b(EUCOMM)Wtsi HET Late adult 5.67×10-07
decreased exploration in new environment Thratm1b(EUCOMM)Wtsi HET   Late adult 6.78×10-05
hyperactivity Thratm1b(EUCOMM)Wtsi HET Late adult 9.31×10-09
abnormal contextual conditioning behavior Thratm1b(EUCOMM)Wtsi HET Late adult 1.82×10-07
hyperactivity Thratm1b(EUCOMM)Wtsi HET Early adult 1.21×10-12
increased bone mineral content Thratm1b(EUCOMM)Wtsi HET Early adult 2.59×10-08
decreased total retina thickness Thratm1b(EUCOMM)Wtsi HET Early adult 1.75×10-20
abnormal body weight Thratm1b(EUCOMM)Wtsi HET Late adult 1.81×10-06
improved glucose tolerance Thratm1b(EUCOMM)Wtsi HET Early adult 2.23×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Section images
Aorta 2 No  (1/590)  (2/2)  Section images
Brain 2 No  (3/590)  (2/2)  Section images
Brainstem 2 No  (2/590)  (2/2)  Section images
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No  (2/2)  Section images
Cerebellum 2 No  (3/590)  (2/2)  Section images
Cerebral cortex 2 No  (2/590)  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (1/590)  (2/2)  Section images
Hippocampus 2 No  (3/590)  (2/2)  Section images
Hypothalamus 2 No  (2/590)  (2/2)  Section images
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590)  (2/2)  Section images
Lymph node 2 No  (2/2)  Section images
Mammary gland 2 No  (1/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/590)  (2/2)  Section images
Ovary 2 No  (1/590)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/590)  (2/2)  Section images
Peripheral nervous system 2 No  (1/590)  (2/2)  Section images
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (1/590)  (2/2)  Section images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No  (2/2)  Section images
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/590)  (2/2)  Section images
Spinal cord 2 No  (2/590)  (2/2)  Section images
Spleen 2 No  (2/590)  (2/2)  Section images
Stomach 2 No  (13/590)  (2/2)  Section images
Striatum 2 No  (3/590)  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  Section images
Thyroid gland 2 No  (16/590)  (2/2)  Section images
Trachea 2 No  (2/590)  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2)  Section images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (2/3) N/A
Dorsal root ganglion 2  (1/61) Image Only N/A
Ear 2  (1/506) Image Only N/A
Embryo 2  (1/507)  (2/3)  Wholemount images
Eye 2  (1/506)  (2/3) N/A
Foot 2  (1/506)  (2/3) N/A
Forebrain 2  (1/506)  (2/3) N/A
Forelimb 2  (1/506)  (2/3) N/A
Fronto-nasal process 2  (1/62) Image Only N/A
Hand 2  (1/506)  (2/3) N/A
Head 2  (5/506)  (2/3) N/A
Heart 2  (1/506)  (2/3) N/A
Hindbrain 2  (6/506)  (2/3) N/A
Hindlimb 2  (1/506)  (2/3) N/A
Liver 2  (1/504) Image Only N/A
Lung 2  (1/504) Image Only N/A
Mandibular process 2  (1/506)  (2/3) N/A
Maxillary process 2  (1/506)  (2/3) N/A
Midbrain 2  (1/506)  (2/3) N/A
Nose 2  (1/76)  (2/2) N/A
Oral cavity 2  (1/504) Image Only N/A
Skin 2  (1/506)  (2/3) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Tail 2  (1/506)  (2/3) N/A
Tail somite 2  (1/506)  (2/3) N/A

 Associated Images

Original Image
Adult LacZ: LacZ Images Section
45 Images
X-ray: XRay Images Whole Body Dorso Ventral
20 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
20 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
12 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Thratm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Thratm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Thratm357(L1L2_gt2) Targeting vectors
Thratm43807(L1L2_gt1) Targeting vectors
Thratm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells