Gene: Thra

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Name
thyroid hormone receptor alpha
MGI ID
MGI:98742
Synonyms
Thra2 TR alpha 2 Erba Thra1 TR alpha 1 6430529J03Rik T3R[a] T3Ralpha Nr1a1 c-erbAalpha Rvr
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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Thratm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased body length Thratm1b(EUCOMM)Wtsi HET postnatal 3.53×10-06
abnormal behavioral response to light Thratm1b(EUCOMM)Wtsi HET postnatal 3.10×10-05
decreased grip strength Thratm1b(EUCOMM)Wtsi HET postnatal 5.63×10-08
increased bone mineral content Thratm1b(EUCOMM)Wtsi HET postnatal 9.40×10-15
hyperactivity Thratm1b(EUCOMM)Wtsi HET postnatal 2.60×10-08
abnormal behavior Thratm1b(EUCOMM)Wtsi HET postnatal 1.76×10-13
decreased total retina thickness Thratm1b(EUCOMM)Wtsi HET postnatal 1.10×10-10
abnormal eye anterior chamber depth Thratm1b(EUCOMM)Wtsi HET postnatal 4.13×10-05
abnormal retinal inner nuclear layer morphology Thratm1b(EUCOMM)Wtsi HET postnatal 1.40×10-05
increased circulating alkaline phosphatase level Thratm1b(EUCOMM)Wtsi HET postnatal 1.16×10-06
decreased total body fat amount Thratm1b(EUCOMM)Wtsi HET postnatal 2.09×10-07
limb grasping Thratm1b(EUCOMM)Wtsi HET postnatal 4.70×10-06
increased startle reflex Thratm1b(EUCOMM)Wtsi HET postnatal 3.43×10-09

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No  (2/2)  Section images
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2)  Section images
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No  (2/2)  Section images
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2)  Section images
Hippocampus 2 No  (2/2)  Section images
Hypothalamus 2 No  (2/2)  Section images
Kidney 2 No  (18/584)  (2/2)  Section images
Large intestine 2 No  (10/584)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No  (2/2)  Section images
Mammary gland 2 No  (1/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/2)  Section images
Ovary 2 No  (1/584)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No  (2/2)  Section images
Peyer's patch 2 No  (2/2)  Section images
Pituitary gland 2 No  (2/2)  Section images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No  (2/2)  Section images
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584)  (2/2)  Section images
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584)  (2/2)  Section images
Stomach 2 No  (12/584)  (2/2)  Section images
Striatum 2 No  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (2/584)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  Section images
Thyroid gland 2 No  (15/584)  (2/2)  Section images
Trachea 2 No  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2)  Section images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (2/3) N/A
Dorsal root ganglion 2  (1/47) Image Only N/A
Ear 2  (1/485) Image Only N/A
Embryo 2  (1/485)  (2/3)  Wholemount images
Eye 2  (1/485)  (2/3) N/A
Foot 2  (1/485)  (2/3) N/A
Forebrain 2  (1/485)  (2/3) N/A
Forelimb 2  (1/485)  (2/3) N/A
Fronto-nasal process 2  (1/48) Image Only N/A
Hand 2  (1/485)  (2/3) N/A
Head 2  (5/485)  (2/3) N/A
Heart 2  (1/485)  (2/3) N/A
Hindbrain 2  (6/485)  (2/3) N/A
Hindlimb 2  (1/485)  (2/3) N/A
Liver 2  (1/485) Image Only N/A
Lung 2  (1/485) Image Only N/A
Mandibular process 2  (1/485)  (2/3) N/A
Maxillary process 2  (1/485)  (2/3) N/A
Midbrain 2  (1/485)  (2/3) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 2  (1/485) Image Only N/A
Skin 2  (1/485)  (2/3) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 2  (1/485)  (2/3) N/A
Tail somite 2  (1/485)  (2/3) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
X-ray: XRay Images Lateral Orientation
18 Images
X-ray: XRay Images Skull Lateral Orientation
8 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Forepaw
8 Images
Original Image
Adult LacZ: LacZ Images Section
45 Images
X-ray: XRay Images Dorso Ventral
18 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Thratm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Thratm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Thratm357(L1L2_gt2) Targeting vectors
Thratm43807(L1L2_gt1) Targeting vectors
Thratm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells