Dntt | deoxynucleotidyltransferase, terminal

GeneMGI:98659Synonyms: Tdt

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

16 No significant impact

6 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

increased circulating sodium level1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult2.51x10-7 
increased circulating HDL cholesterol level1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult8.09x10-9 
increased circulating cholesterol level1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult1.58x10-7 
increased coping response1 supporting datasetDntttm2b(KOMP)WtsihomozygoteEarly adult7.55x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Dntttm119376(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Dntttm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Dntttm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Dntttm2b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Dntttm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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