Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
teratocarcinoma-derived growth factor 1
Synonyms:
cripto,  CR1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tdgf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases predicted to be associated to Tdgf1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Holoprosencephaly 5
Semilobar holoprosencephaly, Hypertelorism, Holoprosencephaly, Alobar holoprosencephaly, Lobar ho... OMIM:609637
Acalvaria
Holoprosencephaly, Spina bifida, Hypertelorism, Hydrocephalus ORPHA:945
Holoprosencephaly-Caudal Dysgenesis Syndrome
Hypertelorism, Cyclopia, Holoprosencephaly, Proptosis, Abnormality of the diencephalon, Microcephaly ORPHA:2165
Solitary Median Maxillary Central Incisor
Coloboma, Cyclopia, Holoprosencephaly, Microcephaly, Hypotelorism, Anterior hypopituitarism, Decr... OMIM:147250
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly, Microcephaly, Cerebral cortical atrophy ORPHA:2523
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Deeply set eye, Cerebral cortical a... ORPHA:2570
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly, Chorioretinal coloboma, Iris coloboma OMIM:611638
Holoprosencephaly With Fetal Akinesia/Hypokinesia Sequence
Holoprosencephaly, Microcephaly OMIM:306990
Holoprosencephaly 11
Holoprosencephaly, Proptosis, Microcephaly, Hypotelorism, Agenesis of corpus callosum OMIM:614226
Hydrocephalus, Congenital, 3, With Brain Anomalies
Holoprosencephaly, Hydranencephaly, Hydrocephalus OMIM:617967
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly, Agenesis of corpus callosum, Cyclopia ORPHA:990
Aminopterin/Methotrexate Embryofetopathy
Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Spinal dysraphism, P... ORPHA:1908
Microform Holoprosencephaly
Panhypopituitarism, Cyclopia, Holoprosencephaly, Iris coloboma, Microcephaly, Hypotelorism, Agene... ORPHA:280200
Chromosome 1Q41-Q42 Deletion Syndrome
Holoprosencephaly, Deeply set eye, Hypotelorism, Microcephaly OMIM:612530
Distal Monosomy 13Q
Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Iris coloboma, Anenc... ORPHA:1590
Pseudotrisomy 13 Syndrome
Agenesis of corpus callosum, Cyclopia, Holoprosencephaly, Polymicrogyria, Microcephaly, Hypotelor... OMIM:264480
Trisomy 18
Spina bifida, Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Cyclopia, Holoprosencepha... ORPHA:3380
Holoprosencephaly
Chorioretinal coloboma, Panhypopituitarism, Hypertelorism, Aplasia/Hypoplasia of the corpus callo... ORPHA:2162
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Hydrocephalus, Absent septum pellucidum, Holoprosencephaly, Aqueductal stenosis, Agenesis of corp... ORPHA:2182
Holoprosencephaly 3
Cyclopia, Holoprosencephaly, Proptosis, Central diabetes insipidus, Microcephaly, Hypotelorism OMIM:142945
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Holoprosencephaly-Postaxial Polydactyly Syndrome
Aplasia/Hypoplasia of the corpus callosum, Cyclopia, Holoprosencephaly, Umbilical hernia, Microce... ORPHA:2166
Triploidy
Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Iris coloboma, Menin... ORPHA:3376
16P13.11 Microdeletion Syndrome
Holoprosencephaly, Microcephaly, Agenesis of corpus callosum, Cyclopia ORPHA:261236
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly, Coloboma, Absent septum pellucidum OMIM:601357
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Hartsfield Syndrome
Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Lobar holoprosencephaly ORPHA:2117
Vissers-Bodmer Syndrome
Holoprosencephaly OMIM:619033
Alobar Holoprosencephaly
Panhypopituitarism, Agenesis of corpus callosum, Cyclopia, Abnormal hypothalamus physiology, Neur... ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Panhypopituitarism, Agenesis of corpus callosum, Cyclopia, Abnormal hypothalamus physiology, Neur... ORPHA:93926
Lobar Holoprosencephaly
Panhypopituitarism, Agenesis of corpus callosum, Cyclopia, Abnormal hypothalamus physiology, Neur... ORPHA:93924
Semilobar Holoprosencephaly
Panhypopituitarism, Agenesis of corpus callosum, Cyclopia, Abnormal hypothalamus physiology, Neur... ORPHA:220386
Holoprosencephaly 13, X-Linked
Semilobar holoprosencephaly, Agenesis of corpus callosum, Cyclopia, Alobar holoprosencephaly, Sep... OMIM:301043
Chromosome 3Q13.31 Deletion Syndrome
Hypertelorism, Alobar holoprosencephaly, Agenesis of corpus callosum OMIM:615433
Holoprosencephaly, Recurrent Infections, And Monocytosis
Holoprosencephaly, Microcephaly, Agenesis of corpus callosum OMIM:610680
Thanatophoric Dysplasia Type 2
Holoprosencephaly, Hydrocephalus, Proptosis ORPHA:93274
Holoprosencephaly 2
Cyclopia, Holoprosencephaly, Anterior pituitary agenesis, Microcephaly, Hypotelorism, Agenesis of... OMIM:157170
Lambotte Syndrome
Semilobar holoprosencephaly, Microcephaly, Hypertelorism OMIM:245552
Ring Chromosome 21 Syndrome
Holoprosencephaly, Microcephaly ORPHA:1445
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Cyclopia, Holoprosencephaly, Iris coloboma, Microcephaly, Hypotelorism ORPHA:3186
Distal Monosomy 7Q36
Holoprosencephaly, Microcephaly ORPHA:1636
1Q41Q42 Microdeletion Syndrome
Holoprosencephaly, Deeply set eye, Hypotelorism ORPHA:250999
Monosomy 18P
Holoprosencephaly, Microcephaly ORPHA:1598
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly, Hypotelorism, Microcephaly ORPHA:2163
Agnathia-Otocephaly Complex
Holoprosencephaly, Agenesis of corpus callosum OMIM:202650
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Holoprosencephaly, Iris coloboma, Hydrocephalus, Agenesis of corpus callosum ORPHA:77298
Holoprosencephaly 1
Ethmocephaly, Cyclopia, Alobar holoprosencephaly, Microcephaly, Hypotelorism, Agenesis of corpus ... OMIM:236100
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Hypoplasia of the brainstem, Pachygyria, Type II lissencephaly, Agenesis of corpus callosum, Holo... OMIM:253800
49,Xxxxy Syndrome
Holoprosencephaly, Arrhinencephaly, Hypoplasia of the corpus callosum, Hypertelorism ORPHA:96264
Iniencephaly
Spina bifida, Holoprosencephaly, Spinal dysraphism, Anencephaly, Myelomeningocele, Hydrocephalus,... ORPHA:63259
Septopreoptic Holoprosencephaly
Abnormality of the septum pellucidum, Abnormal midbrain morphology, Megalencephaly, Abnormal corp... ORPHA:280195
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Pachygyria, Abnormal periventricular white matter morphology, Simplified gyral pattern, Hypoplasi... ORPHA:468631
Isolated Exencephaly
Holoprosencephaly, Posterior pituitary agenesis, Proptosis, Anterior pituitary hypoplasia, Agenes... ORPHA:563612
Holoprosencephaly 7
Semilobar holoprosencephaly, Panhypopituitarism, Agenesis of corpus callosum, Fusion of the left ... OMIM:610828
Coach Syndrome 2
Chorioretinal coloboma, Coloboma, Hydrocephalus, Molar tooth sign on MRI, Agenesis of corpus call... OMIM:619111
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies
Semilobar holoprosencephaly, Agenesis of corpus callosum, Colpocephaly, Umbilical hernia OMIM:618651
Jacobsen Syndrome
Chorioretinal coloboma, Hypertelorism, Holoprosencephaly, Iris coloboma, Microcephaly, Hydrocephalus OMIM:147791
Endocrine-Cerebroosteodysplasia
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Hydrocephalus OMIM:612651
Holoprosencephaly 4
Semilobar holoprosencephaly, Hypotelorism OMIM:142946
Pancreatic Agenesis-Holoprosencephaly Syndrome
Semilobar holoprosencephaly, Holoprosencephaly, Hypotelorism, Agenesis of corpus callosum ORPHA:556955
Hydrolethalus Syndrome 2
Molar tooth sign on MRI, Agenesis of corpus callosum, Hydrocephalus, Anencephaly OMIM:614120
Microtia-Anotia
Holoprosencephaly OMIM:600674
Holoprosencephaly 9
Panhypopituitarism, Holoprosencephaly, Anterior pituitary agenesis, Decreased response to growth ... OMIM:610829
Microtia
Holoprosencephaly ORPHA:83463
Meckel Syndrome, Type 4
Hypoplasia of the corpus callosum, Anencephaly, Meningocele, Microcephaly, Molar tooth sign on MR... OMIM:611134
Short-Rib Thoracic Dysplasia 12
Holoprosencephaly, Hypertelorism, Hydrocephalus, Anencephaly OMIM:269860
Genitourinary And/Or Brain Malformation Syndrome
Hypertelorism, Agenesis of corpus callosum, Absent septum pellucidum, Holoprosencephaly, Dysplast... OMIM:618820
Monosomy 13Q14
Hypertelorism, Holoprosencephaly, Hypoplasia of the corpus callosum, Iris coloboma, Microcephaly ORPHA:1587
Steinfeld Syndrome
Retinal coloboma, Holoprosencephaly, Iris coloboma OMIM:184705
Hartsfield Syndrome
Hypertelorism, Lobar holoprosencephaly, Microcephaly, Hypotelorism, Agenesis of corpus callosum, ... OMIM:615465
Pallister-Hall Syndrome
Holoprosencephaly, Panhypopituitarism, Hypothalamic hamartoma, Decreased response to growth hormo... OMIM:146510
Smith-Lemli-Opitz Syndrome
Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Iris coloboma, Propt... ORPHA:818
Orofaciodigital Syndrome Xiv
Retinal coloboma, Holoprosencephaly, Hypoplasia of the corpus callosum, Polymicrogyria, Simplifie... OMIM:615948
Charge Syndrome
Hypertelorism, Coloboma, Retinal coloboma, Arrhinencephaly, Holoprosencephaly, Iris coloboma, Dec... OMIM:214800
Smith-Lemli-Opitz Syndrome
Hypertelorism, Holoprosencephaly, Hypoplasia of the corpus callosum, Hypoplasia of the frontal lo... OMIM:270400
Charge Syndrome
Chorioretinal coloboma, Hypertelorism, Holoprosencephaly, Iris coloboma, Aqueductal stenosis, Mic... ORPHA:138
Mosaic Variegated Aneuploidy Syndrome
Holoprosencephaly, Microcephaly, Aplasia/Hypoplasia of the corpus callosum ORPHA:1052
Combined Pituitary Hormone Deficiencies, Genetic Forms
Ectopic anterior pituitary gland, Absent septum pellucidum, Holoprosencephaly, Anterior pituitary... ORPHA:95494
Slc35A2-Cdg
Cerebral white matter atrophy, Abnormal midbrain morphology, Hypoplasia of the corpus callosum, A... ORPHA:356961
Meckel Syndrome
Hypertelorism, Aplasia/Hypoplasia of the corpus callosum, Anencephaly, Lobar holoprosencephaly, M... ORPHA:564
Pallister-Hall Syndrome
Panhypopituitarism, Hypothalamic hamartoma, Hypertelorism, Holoprosencephaly, Arrhinencephaly, Pi... ORPHA:672
Ring Chromosome 7 Syndrome
Holoprosencephaly, Hypotelorism, Microcephaly, Cerebral cortical atrophy ORPHA:1449
Adult Krabbe Disease
Abnormal corpus callosum morphology, Abnormality of the medulla oblongata, Abnormal pons morpholo... ORPHA:206448
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly, Hypertelorism, Microcephaly, Central diabetes insipidus, Decreased r... OMIM:129900
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Semilobar holoprosencephaly, Hypoplasia of the corpus callosum, Deeply set eye, Microcephaly, Hyp... OMIM:301044
Duplication Of The Pituitary Gland
Abnormality of the pituitary gland, Hypertelorism, Abnormal hypothalamus morphology, Abnormal mid... ORPHA:314621
Amoebiasis Due To Free-Living Amoebae
Abnormal brainstem MRI signal intensity, Abnormal hypothalamus morphology, Abnormal midbrain morp... ORPHA:68
Japanese Encephalitis
Abnormality of thalamus morphology, Focal T2 hyperintense thalamic lesion, Abnormality of the int... ORPHA:79139
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly, Absent mesencephalon OMIM:601374
Cerebellar-Facial-Dental Syndrome
Hypoplasia of the brainstem, Abnormal midbrain morphology, Hypoplasia of the corpus callosum, Per... ORPHA:444072
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hypertelorism, Abnormal midbrain morphology, Decreased response to growth hormone stimuation test... ORPHA:293987

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tdgf1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tdgf1.

No publications found that use IMPC mice or data for Tdgf1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Tdgf1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter