Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
transcription factor 7, T cell specific
Synonyms:
T-cell factor 1,  Tcf1,  T cell factor-1,  TCF-1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tcf7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tcf7 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Hypoplasia of the thymus, Lymphopenia, Agammaglobulinemia OMIM:200900
Reticular Dysgenesis
Leukopenia, Lack of T cell function, Congenital agranulocytosis, Impaired T cell function, Hypopl... OMIM:267500
Immunodeficiency 42
Hypoplasia of the thymus OMIM:616622
Immunodeficiency 40
Lymphopenia OMIM:616433
Immunodeficiency 79
Disseminated cutaneous warts, Decreased proportion of CD4-positive T cells OMIM:619238
Immunodeficiency 24
Decreased circulating IgG level, Reduced antigen-specific T cell proliferation, Reduced proportio... OMIM:615897
Immunodeficiency 18
Decreased proportion of CD3-positive T cells, Lymphopenia, Defective T cell proliferation OMIM:615615
Severe Combined Immunodeficiency Due To Foxn1 Deficiency
T lymphocytopenia, Congenital alopecia totalis ORPHA:169095
Wiskott-Aldrich Syndrome 2
Defective T cell proliferation, Thrombocytopenia, Reduced natural killer cell activity, Decreased... OMIM:614493
Immunodeficiency, Partial Combined, With Absence Of Hla Determinants And Beta-2-Microglobulin From Lymphocytes
Decreased circulating IgG level, T lymphocytopenia OMIM:242870
Combined Immunodeficiency, X-Linked
Decreased circulating IgG level, Decreased proportion of CD4-positive helper T cells, Decreased p... OMIM:312863
Immunodeficiency 15A
Decreased proportion of memory B cells, Decreased proportion of CD4-positive helper T cells, Decr... OMIM:618204
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Reduced antigen-specific T cell proliferation, Increased circulating IgM level, Decreased proport... OMIM:617241
Severe Combined Immunodeficiency, X-Linked
Decreased circulating IgG level, T lymphocytopenia, Decreased circulating total IgM, Decreased ci... OMIM:300400
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Pancytopenia, Splenomegaly, Cutaneous anergy, Decreased helper T cell proportion, Hypersplenism OMIM:183350
Combined Cellular And Humoral Immune Defects With Granulomas
Decreased circulating IgG level, T lymphocytopenia, B lymphocytopenia OMIM:233650
Immunodeficiency 17
Autoimmune hemolytic anemia, Abnormal intestine morphology, Decreased proportion of CD8-positive ... OMIM:615607
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Decreased circulating total IgM, Decreased circulating IgG level, Abnormality of the thymus, Decr... OMIM:611926
Immunodeficiency 14A, Autosomal Dominant
T lymphocytopenia, Increased circulating IgM level, Decreased specific pneumococcal antibody leve... OMIM:615513
Immunodeficiency 8
Lymphopenia OMIM:615401
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy
Decreased helper T cell proportion, T lymphocytopenia, Alopecia, Nail dystrophy OMIM:601705
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Eosinophilia, T lymphocytopenia, Decreased proportion of CD3-positive T cells, Hepatosplenomegaly... ORPHA:169154
Immunodeficiency 76
T lymphocytopenia, Colitis, Splenomegaly, B-cell lymphoma, B lymphocytopenia, Lymphadenopathy, Ly... OMIM:619164
T-Cell Lymphopenia, Infantile, With Or Without Nail Dystrophy, Autosomal Dominant
T lymphocytopenia, Abnormally low T cell receptor excision circle level, Nail dystrophy OMIM:618806
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased T cell activation, Lymphoma, Autoimmune thrombocytopenia, Decreased CD4:CD8 ratio, Decr... OMIM:300853
Cernunnos-Xlf Deficiency
T lymphocytopenia, Thrombocytopenia, Decreased circulating antibody level, Anemia, B lymphocytope... ORPHA:169079
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)
T lymphocytopenia DECIPHER:16
Immunodeficiency 104
T lymphocytopenia, Splenomegaly, Lymphadenopathy OMIM:608971
Cd8 Deficiency, Familial
Absence of CD8-positive T cells OMIM:608957
Epidermodysplasia Verruciformis, Susceptibility To, 5
T lymphocytopenia, Lymphopenia, Verrucae, Squamous cell carcinoma of the skin OMIM:618309
Lymphoid System Deterioration, Progressive
Decreased circulating total IgM, Lymphopenia, Abnormal T cell morphology, Decreased circulating I... OMIM:247630
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Hypoplastic spleen, T lymphocytopenia, Impaired lymphocyte transformation with phytohemagglutinin... OMIM:619313
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
T lymphocytopenia, Lack of T cell function, Absence of lymph node germinal center, Absent tonsils... ORPHA:277
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Decreased circulating total IgM, Decreased circulating IgG level, Cervical lymphadenopathy, Abnor... OMIM:618987
Omenn Syndrome
Eosinophilia, Splenomegaly, Severe B lymphocytopenia, Anemia, B lymphocytopenia, Lymphadenopathy,... OMIM:603554
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive
T lymphocytopenia, Panhypogammaglobulinemia, B lymphocytopenia, Arthritis OMIM:601457
Immunodeficiency 50
Neutropenia, Lymphopenia, Decreased circulating antibody level OMIM:300988
Caspase 8 Deficiency
Decreased T cell activation, Decreased circulating total IgM, Decreased circulating IgG level, De... OMIM:607271
Immunodeficiency 64
Decreased circulating IgG level, Hepatosplenomegaly, Increased circulating IgG level, Abnormal CD... OMIM:618534
Immunodeficiency 85 And Autoimmunity
Decreased circulating IgG level, T lymphocytopenia, Decreased proportion of memory B cells, Decre... OMIM:619510
Combined Immunodeficiency Due To Zap70 Deficiency
Eosinophilia, Hepatosplenomegaly, Lymphadenitis, Lymphoma, Colitis, Autoimmune thrombocytopenia, ... ORPHA:911
Ataxia-Telangiectasia
Decreased circulating IgG level, T lymphocytopenia, Non-Hodgkin lymphoma, Female hypogonadism, Le... OMIM:208900
Combined Immunodeficiency Due To Dock8 Deficiency
T lymphocytopenia, Squamous cell carcinoma, Verrucae, B lymphocytopenia, Squamous cell carcinoma ... ORPHA:217390
Griscelli Syndrome, Type 2
Hepatosplenomegaly, Hemophagocytosis, Melanin pigment aggregation in hair shafts, Silver-gray hai... OMIM:607624
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Leukocytosis, Agammaglobulinemia, Thrombocytosis, Intestinal malrotation, Autoimmune hemolytic an... OMIM:243150
Immunodeficiency 57 With Autoinflammation
T lymphocytopenia, Decreased circulating antibody level, Inflammation of the large intestine, B l... OMIM:618108
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Decreased circulating antibody level, Lymphoproliferative disorder, Hodgkin l... OMIM:618261
Lymphopenic Hypergammaglobulinemia, Antibody Deficiency, Autoimmune Hemolytic Anemia, And Glomerulonephritis
Increased circulating antibody level, Autoimmune hemolytic anemia, Lymphopenia, Plasmacytosis OMIM:247800
Immunodeficiency 70
Decreased circulating total IgM, Colitis, Decreased circulating total IgG, Decreased proportion o... OMIM:618969
T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations
Neutropenia, Lymphopenia, Verrucae OMIM:614868
Immunodeficiency 25
Eosinophilia, T lymphocytopenia, Increased circulating IgG level, Complete or near-complete absen... OMIM:610163
Autoimmune Lymphoproliferative Syndrome
Eosinophilia, Decreased lymphocyte apoptosis, Increased circulating IgG level, Increased circulat... OMIM:601859
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
T lymphocytopenia, Absent natural killer cells, Abnormality of B cell physiology, Impaired lympho... OMIM:600802
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Pancytopenia, Decreased circulating IgG level, T lymphocytopenia, Leukopenia, Hepatosplenomegaly,... OMIM:618986
Immunodeficiency 13
T lymphocytopenia, Decreased CD4:CD8 ratio, Decreased proportion of CD4-positive helper T cells, ... OMIM:615518
Immunodeficiency, Common Variable, 1
Decreased circulating IgG level, Decreased circulating total IgM, Splenomegaly, Decreased circula... OMIM:607594
Neutropenia, Severe Congenital, 2, Autosomal Dominant
Neutropenia, Monocytosis, B lymphocytopenia OMIM:613107
Immunodeficiency 52
Coombs-positive hemolytic anemia, Autoimmune thrombocytopenia, Splenomegaly, Decreased circulatin... OMIM:617514
Immunodeficiency 68
T lymphocytopenia, Lymphadenitis, Abnormal natural killer cell count, B lymphocytopenia, Septic a... OMIM:612260
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Colitis, Increased CD4:CD8 ratio, Impaired lymphocyte transformation with phytohemagglutinin, Dec... OMIM:617006
Combined Immunodeficiency Due To Partial Rag1 Deficiency
T lymphocytopenia, Autoimmune hemolytic anemia, Splenomegaly, Neutropenia in presence of anti-neu... ORPHA:231154
Immunodeficiency 72 With Autoinflammation
Increased circulating IgG level, Hepatosplenomegaly, Increased proportion of memory T cells, Lymp... OMIM:618982
T-Cell Immunodeficiency With Thymic Aplasia
Hepatosplenomegaly, Aplasia of the thymus, Reduced delayed hypersensitivity, Lymphopenia, Abnorma... OMIM:242700
Neutropenia, Severe Congenital, 4, Autosomal Recessive
High palate, Leukopenia, Monocytosis, Cryptorchidism, Splenomegaly, Neutropenia, Anemia, Lymphope... OMIM:612541
Immunodeficiency 81
Reduced antigen-specific T cell proliferation, Impaired neutrophil chemotaxis, Reduced natural ki... OMIM:619374
Transcobalamin Deficiency
Pancytopenia, Decreased circulating total IgM, Decreased circulating IgG level, Decreased circula... ORPHA:859
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
T lymphocytopenia, Patchy alopecia, Hepatosplenomegaly, Hypothyroidism, Decreased proportion of C... OMIM:606367
Bone Marrow Failure Syndrome 6
Squamous cell carcinoma of the tongue, Hypothyroidism, Osteopenia, Bone marrow hypocellularity, N... OMIM:618849
Immunodeficiency With Hyper-Igm, Type 3
Decreased circulating IgG level, Decreased circulating IgE, Increased circulating IgM level, Abse... OMIM:606843
Immunodeficiency 21
Neutropenia, Abnormal natural killer cell morphology, Myelodysplasia, Myeloid leukemia, Aplastic ... OMIM:614172
Selective Igm Deficiency
Decreased circulating total IgM, Decreased proportion of CD8-positive T cells, Decreased proporti... ORPHA:331235
Lymphangiectasia, Intestinal
Intestinal lymphangiectasia, Decreased circulating IgG level, Abnormal hair morphology, Malabsorp... OMIM:152800
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Eosinophilia, Decreased circulating total IgM, Reduced red cell adenosine deaminase level, Autoim... OMIM:102700
Lymphoproliferative Syndrome 1
Pancytopenia, Decreased circulating IgG level, Leukopenia, Autoimmune hemolytic anemia, Autoimmun... OMIM:613011
Autoimmune Lymphoproliferative Syndrome, Type Iia
Eosinophilia, Decreased lymphocyte apoptosis, Increased circulating IgG level, Increased circulat... OMIM:603909
Progressive Multifocal Leukoencephalopathy
Abnormal proportion of CD4-positive T cells, Hematological neoplasm, Decreased proportion of CD8-... ORPHA:217260
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Decreased circulating IgG level, T lymphocytopenia, Rectovaginal fistula, Hepatosplenomegaly, Par... ORPHA:35078
Monocyte Chemotactic Disorder
Cutaneous anergy OMIM:252250
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Decreased circulating IgG level, Decreased proportion of CD3-positive T cells, Increased circulat... ORPHA:276
X-Linked Lymphoproliferative Disease
Pancytopenia, Decreased circulating IgG level, Histiocytosis, Absent natural killer cells, Increa... ORPHA:2442
Burkitt Lymphoma
Abnormality of the ovary, Decreased proportion of CD4-positive helper T cells, Abnormality of the... ORPHA:543
Immunodeficiency, Common Variable, 2
Decreased circulating IgG level, Lymphoma, Splenomegaly, Decreased circulating IgA level, Neoplas... OMIM:240500
Candidiasis, Familial, 1
Cutaneous anergy, Abnormality of the endocrine system, Alopecia OMIM:114580
Retinal Telangiectasia And Hypogammaglobulinemia
Decreased circulating IgG level, Reduced delayed hypersensitivity OMIM:267900
Immunodeficiency By Defective Expression Of Mhc Class Ii
Pancytopenia, T lymphocytopenia, Abnormal CD4:CD8 ratio, Lack of T cell function, Autoimmune thro... ORPHA:572
Wiskott-Aldrich Syndrome
Eosinophilia, Decreased circulating total IgM, Increased circulating IgA level, Autoimmune hemoly... OMIM:301000
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Eosinophilia, Decreased circulating IgG level, Reduced antigen-specific T cell proliferation, Dec... ORPHA:331206
Pgm3-Cdg
Decreased proportion of CD3-positive T cells, Lymphoma, Decreased proportion of CD4-positive help... ORPHA:443811
Ghosal Hematodiaphyseal Dysplasia
Myelofibrosis, Leukopenia, Increased bone mineral density, Bone marrow hypocellularity, Hyperosto... OMIM:231095
Immunodeficiency 36
Splenomegaly, Decreased circulating antibody level, B-cell lymphoma, Chronic lymphatic leukemia, ... OMIM:616005
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
T lymphocytopenia, Increased circulating IgM level, Decreased circulating IgA level, Macroglossia... OMIM:242860
Autoimmune Lymphoproliferative Syndrome
Decreased circulating IgG level, Autoimmune hemolytic anemia, Decreased proportion of CD4-positiv... ORPHA:3261
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive
Eosinophilia, Decreased circulating total IgM, Squamous cell carcinoma, Increased circulating IgG... OMIM:243700
Syndromic Diarrhea
Hepatoblastoma, Brittle hair, Hypopigmentation of hair, Woolly hair, Hypothyroidism, Thrombocytos... ORPHA:84064
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Decreased circulating IgG level, T lymphocytopenia, Craniosynostosis, Hypereosinophilia, Decrease... ORPHA:508533
Obesity Due To Congenital Leptin Deficiency
Decreased T cell activation, Hyperinsulinemia, Decreased serum testosterone concentration, Decrea... ORPHA:66628
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Lymph node hypoplasia, Panhypogammaglobulinemia, Aplasia of the thymus OMIM:602450
Wiskott-Aldrich Syndrome
Microcytic anemia, Chronic leukemia, Abnormal platelet function, Lymphoma, Abnormal eosinophil mo... ORPHA:906
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Decreased circulating IgG level, Decreased circulating total IgM, Arthritis, Autoimmune thrombocy... OMIM:616100
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Abnormal CD4:CD8 ratio, Intermittent thrombocytopenia, Splenomegaly, Neutropenia, B lymphocytopen... OMIM:150550
Obesity Due To Leptin Receptor Gene Deficiency
Decreased T cell activation, Hyperinsulinemia, Decreased serum testosterone concentration, Decrea... ORPHA:179494
Thymic Aplasia
T lymphocytopenia, Hypothyroidism, Coombs-positive hemolytic anemia, Decreased proportion of naiv... ORPHA:83471
Immunodeficiency With Hyper-Igm, Type 1
Decreased T cell activation, Decreased circulating IgG level, Decreased circulating IgE, Increase... OMIM:308230
Purine Nucleoside Phosphorylase Deficiency
Lymphoma, Autoimmune thrombocytopenia, Autoimmune hemolytic anemia, Splenomegaly, Abnormality of ... OMIM:613179
Agammaglobulinemia, X-Linked
Decreased circulating IgG level, T lymphocytopenia, Decreased circulating total IgM, Decreased ci... OMIM:300755
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Lethal Congenital Contracture Syndrome 10
Hypoplasia of the thymus, High palate, Stiff neck, Narrow palate OMIM:617022
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Eosinophilia, Decreased circulating IgG level, Hepatosplenomegaly, Decreased proportion of CD3-po... ORPHA:169160
Progeria-Short Stature-Pigmented Nevi Syndrome
Microcytic anemia, Generalized osteoporosis, T lymphocytopenia, Bifid uvula, Osteopenia, Multiple... ORPHA:2959
Acitretin/Etretinate Embryopathy
Hypoplasia of the thymus, High palate, Median cleft palate ORPHA:40366
Peroxisome Biogenesis Disorder 2A (Zellweger)
Cryptorchidism, Hypoplasia of the thymus, Camptodactyly, Cleft palate, Joint contracture of the hand OMIM:214110
Cowden Syndrome 7
Papillary thyroid carcinoma, Goiter, Hashimoto thyroiditis, Papilloma, Breast carcinoma, Hemangio... OMIM:616858
Aregenerative Anemia
Pancytopenia, Bone marrow hypocellularity, Decreased proportion of CD4-positive helper T cells, A... ORPHA:101096
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Pancytopenia, T lymphocytopenia, Decreased proportion of memory B cells, Hepatosplenomegaly, Abse... ORPHA:79124
Combined Immunodeficiency-Enteropathy Spectrum
Rectal abscess, Hashimoto thyroiditis, Intestinal malrotation, Autoimmune hemolytic anemia, Spars... ORPHA:436252
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Decreased circulating IgG level, Decreased proportion of CD3-positive T cells, Hashimoto thyroidi... ORPHA:275
Nijmegen Breakage Syndrome
T lymphocytopenia, Rhabdomyosarcoma, Anal stenosis, Lymphoma, Dysgammaglobulinemia, Autoimmune he... OMIM:251260
Isolated Anencephaly
Thymus hyperplasia, Maternal diabetes, Adrenal hypoplasia ORPHA:563609
Immunodeficiency 22
Decreased proportion of CD4-positive helper T cells OMIM:615758
Common Variable Immunodeficiency
Gastrointestinal stroma tumor, Lymphoma, Autoimmune thrombocytopenia, Splenomegaly, Decreased cir... ORPHA:1572
Dyskeratosis Congenita, Autosomal Dominant 1
Premature graying of hair, Oral leukoplakia, Bone marrow hypocellularity, Squamous cell carcinoma... OMIM:127550
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Reduction of neutrophil motility, Leukocytosis, Impaired neutrophil chemotaxis, Rectal abscess, N... OMIM:608203
Mirror Polydactyly-Vertebral Segmentation-Limbs Defects Syndrome
Duodenal atresia, Aplasia of the thymus ORPHA:3004
Wiskott-Aldrich Syndrome, Autosomal Dominant
Decreased circulating total IgM, Increased circulating IgA level, Absent microvilli on the surfac... OMIM:600903
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Agammaglobulinemia, Aganglionic megacolon, Fine hair, Anemia, White hair, Malabsorption, Reduced ... ORPHA:935
Treacher-Collins Syndrome
High palate, Rectovaginal fistula, Multiple enchondromatosis, Cryptorchidism, Abnormal hair morph... ORPHA:861
Immunodeficiency 82 With Systemic Inflammation
Decreased circulating total IgG, Osteomalacia, Anemia, Villous atrophy, Reduced natural killer ce... OMIM:619381
Bare Lymphocyte Syndrome, Type Ii
Agammaglobulinemia, Colitis, Neutropenia, Cutaneous anergy, Panhypogammaglobulinemia, Malabsorpti... OMIM:209920
Carney Complex
Testicular adrenal rest tumor, Neoplasm of the breast, Ovarian carcinoma, Increased circulating p... ORPHA:1359
Spondyloenchondrodysplasia With Immune Dysregulation
T lymphocytopenia, Hypothyroidism, Autoimmune thrombocytopenia, Sclerosis of skull base, Neutrope... OMIM:607944
Schimke Immuno-Osseous Dysplasia
Non-Hodgkin lymphoma, Bone marrow hypocellularity, Abnormality of thyroid physiology, Abnormal pr... ORPHA:1830
Proteus-Like Syndrome
Subcutaneous lipoma, Polycystic ovaries, Splenomegaly, Abnormality of the parathyroid gland, Thym... ORPHA:2969
Vici Syndrome
Decreased T cell activation, Decreased circulating IgG level, Hypopigmentation of hair, Albinism,... OMIM:242840
Eec Syndrome
Coarse hair, Lymphoma, Thick eyebrow, Sparse eyebrow, Anterior hypopituitarism, Fine hair, Slow-g... ORPHA:1896
Bloom Syndrome
Decreased circulating IgG level, Patchy alopecia, Lymphoma, Neoplasm of the breast, Recurrent ton... ORPHA:125
Combined Immunodeficiency With Faciooculoskeletal Anomalies
Decreased circulating total IgM, Osteopenia, Decreased circulating total IgG, Decreased lymphocyt... ORPHA:221139
Monosomy 22
High palate, Hepatosplenomegaly, Schwannoma, Sarcoma, Contractures of the large joints, Meningiom... ORPHA:96123
Gastrointestinal Stromal Tumor
Gastrointestinal stroma tumor, Esophageal neoplasm, Neoplasm of the gastrointestinal tract, Sarco... ORPHA:44890
22Q11.2 Deletion Syndrome
Cholelithiasis, Hypothyroidism, Multiple suture craniosynostosis, Cryptorchidism, Intestinal malr... ORPHA:567
Digeorge Syndrome
Cholelithiasis, High palate, Hypothyroidism, Bifid uvula, Parathyroid agenesis, Abnormality of th... OMIM:188400
Carney Triad
Gastrointestinal stroma tumor, Paraganglioma, Leiomyosarcoma, Adrenal overactivity, Anemia, Pheoc... ORPHA:139411
Congenital Disorder Of Glycosylation, Type Iil
Pancytopenia, Splenomegaly, Impaired T cell function, Inflammation of the large intestine, Esopha... OMIM:614576
Orotic Aciduria
Folate-unresponsive megaloblastic anemia, Hypochromia, Anisocytosis, Impaired T cell function, Py... OMIM:258900
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Hypochromic anemia, Decreased T cell activation, Leukocytosis, Increased circulating IgG level, T... OMIM:618213
Hereditary Orotic Aciduria
Anemia, Splenomegaly, Impaired T cell function ORPHA:30
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Decreased serum testosterone concentration, Splenomegaly, Impaired T cell function, Alopecia of s... OMIM:201100
Sarcoidosis, Susceptibility To, 1
Pancytopenia, Abnormal salivary gland morphology, Abnormality of T cell physiology, Enlarged lacr... OMIM:181000
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Thymus hyperplasia, Congenital contracture OMIM:619036
Paragangliomas 4
Gastrointestinal stroma tumor, Chemodectoma, Paraganglioma, Neuroblastoma, Paraganglioma of head ... OMIM:115310
Primary Sjögren Syndrome
Leukopenia, Normocytic anemia, Parotitis, Lymphoma, Decreased proportion of CD4-positive helper T... ORPHA:289390
Immunodeficiency 58
Decreased T cell activation, Cutaneous abscess, Colitis, Decreased circulating antibody level, Ve... OMIM:618131
Proteus Syndrome
Diabetes insipidus, Lymphangioma, Meningioma, Lipoma, Neoplasm of the lung, Capillary hemangioma,... ORPHA:744
17Q11 Microdeletion Syndrome
Gastrointestinal stroma tumor, Plexiform neurofibroma, Neurofibrosarcoma, Osteoporosis, Atypical ... ORPHA:97685
Truncus Arteriosus
Hypoplasia of the thymus, Adrenocortical abnormality ORPHA:3384
Dermatomyositis
Gastrointestinal stroma tumor, Arthritis, Lymphoma, Breast carcinoma, Abnormal eosinophil morphol... ORPHA:221
Gastrointestinal Stromal Tumor
Gastrointestinal stroma tumor, Neurofibromas, Intestinal obstruction OMIM:606764
Gist-Plus Syndrome
Gastrointestinal stroma tumor, Intestinal polyposis, Intussusception OMIM:175510
Carney-Stratakis Syndrome
Gastrointestinal stroma tumor, Paraganglioma, Intestinal obstruction ORPHA:97286
Velocardiofacial Syndrome
Velopharyngeal insufficiency, Cryptorchidism, Impaired T cell function, Submucous cleft hard pala... OMIM:192430
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Abnormality of T cell physiology, Hypoparathyroidism, Diabetes mellitus, Cleft palate, Parathyroi... ORPHA:2237
Progeroid Short Stature With Pigmented Nevi
Impaired T cell function, Diabetes mellitus, Numerous nevi, Premature ovarian insufficiency, Dela... OMIM:176690

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tcf7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tcf7.

There are 39 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The E protein-TCF1 axis controls γδ T cell development and effector fate. Cell reports (February 2021) Tcf7tm1c(EUCOMM)Wtsi PMC7919611
TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus. Development (Cambridge, England) (August 2020) Tcf7l2tm1c(EUCOMM)Wtsi Tcf7l2tm1a(EUCOMM)Wtsi 32675279
β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. eLife (August 2020) Tcf7l1tm1a(EUCOMM)Wtsi PMC7462606
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Tcf7l2tm1a(EUCOMM)Wtsi PMC7263671
T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development. Cell reports (April 2020) Tcf7tm1a(EUCOMM)Wtsi 32268106
Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells. Oncogene (March 2020) Tcf7l2tm1a(EUCOMM)Wtsi PMC7203011
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Tcf7l2tm1a(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Tcf7l1tm1a(EUCOMM)Wtsi Tcf7l2tm1a(EUCOMM)Wtsi PMC6671969
Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8+ T Cells in Acute Viral Infection. Journal of immunology (Baltimore, Md. : 1950) (June 2019) Tcf7tm1c(EUCOMM)Wtsi 31175159
TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell reports (June 2019) Tcf7tm1c(EUCOMM)Wtsi PMC6701704
TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. The Journal of experimental medicine (May 2019) Tcf7tm1c(EUCOMM)Wtsi PMC6605755
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Tcf7l1tm1a(EUCOMM)Wtsi Tcf7l2tm1a(EUCOMM)Wtsi PMC6459510
Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. Molecular metabolism (March 2019) Tcf7l2tm1a(EUCOMM)Wtsi PMC6531814
Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. The Journal of experimental medicine (March 2019) Tcf7tm1c(EUCOMM)Wtsi 30837262
The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection. Frontiers in immunology (February 2019) Tcf7tm1c(EUCOMM)Wtsi PMC6381939
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells. Immunity (January 2019) Tcf7tm1c(EUCOMM)Wtsi Tcf7tm1a(EUCOMM)Wtsi 30635236
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes. Nature immunology (November 2018) Tcf7tm1c(EUCOMM)Wtsi PMC6867931
Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Nature communications (September 2018) Tcf7tm1c(EUCOMM)Wtsi PMC6125341
Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells. Genes (September 2018) Tcf7l2tm1a(EUCOMM)Wtsi PMC6162433
Tcf7L2 is essential for neurogenesis in the developing mouse neocortex. Neural development (May 2018) Tcf7l2tm1a(EUCOMM)Wtsi PMC5946422
TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. Journal of immunology (Baltimore, Md. : 1950) (April 2018) Tcf7tm1c(EUCOMM)Wtsi 29632143
Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation. Cell reports (February 2018) Tcf7tm1c(EUCOMM)Wtsi Tcf7tm1a(EUCOMM)Wtsi 29466737
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017)