Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
surfeit gene 1
Synonyms:
Surf-1,  0610010F23Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Surf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Surf1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Leigh Syndrome With Leukodystrophy
Progressive cerebellar ataxia, Failure to thrive ORPHA:255241
Leigh Syndrome With Cardiomyopathy
Ataxia, Failure to thrive, Chorea ORPHA:70474
Charcot-Marie-Tooth Disease, Type 4K
Ataxia OMIM:616684
Mitochondrial Complex Iv Deficiency, Nuclear Type 1
Failure to thrive, Ataxia OMIM:220110

The table below shows human diseases predicted to be associated to Surf1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism, Ataxia ORPHA:31
Friedreich Ataxia
Decreased pyruvate carboxylase activity, Impaired proprioception, Impaired vibratory sensation, A... OMIM:229300
Methylmalonic Aciduria And Homocystinuria, Cbld Type
Decreased methionine synthase activity, Spastic ataxia, Decreased methylmalonyl-CoA mutase activity OMIM:277410
Hereditary Leiomyomatosis And Renal Cell Cancer
Decreased fumarate hydratase activity OMIM:150800
Mitochondrial Dna-Associated Leigh Syndrome
Abnormality of Krebs cycle metabolism, Ataxia, Gait ataxia, Failure to thrive, Chorea ORPHA:255210
Methylmalonic Aciduria, Cblb Type
Failure to thrive, Decreased methylmalonyl-CoA mutase activity OMIM:251110
Methylmalonic Aciduria, Cbla Type
Failure to thrive, Decreased methylmalonyl-CoA mutase activity OMIM:251100
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Failure to thrive, Decreased methylmalonyl-CoA mutase activity OMIM:277400
Charcot-Marie-Tooth Peroneal Muscular Atrophy And Friedreich Ataxia, Combined
Decreased pyruvate carboxylase activity, Impaired proprioception, Impaired vibratory sensation, A... OMIM:302900
Friedreich Ataxia 2
Decreased pyruvate carboxylase activity, Ataxia, Impaired vibratory sensation OMIM:601992
Friedreich Ataxia And Congenital Glaucoma
Decreased pyruvate carboxylase activity, Ataxia, Impaired vibratory sensation OMIM:229310
Leigh Syndrome With Leukodystrophy
Progressive cerebellar ataxia, Failure to thrive ORPHA:255241
Leigh Syndrome With Cardiomyopathy
Ataxia, Failure to thrive, Chorea ORPHA:70474
Charcot-Marie-Tooth Disease, Type 4K
Ataxia OMIM:616684
Mitochondrial Complex Iv Deficiency, Nuclear Type 1
Failure to thrive, Ataxia OMIM:220110

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Surf1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Surf1.

No publications found that use IMPC mice or data for Surf1.

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MGI Allele Allele Type Produced
Surf1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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