Gene: Spp1

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Name
secreted phosphoprotein 1
MGI ID
MGI:98389
Synonyms
44kDa bone phosphoprotein bone sialoprotein 1 osteopontin ETA-1 BNSP minopontin Opn Opnl Ric Spp-1 OP Apl-1 osteopontin-like protein 2ar
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
anophthalmia Spp1tm1.1(KOMP)Vlcg HOM   Early adult 5.81×10-06
corneal opacity Spp1tm1.1(KOMP)Vlcg HOM   Early adult 5.36×10-05
sclerocornea Spp1tm1.1(KOMP)Vlcg HOM   Early adult 9.13×10-05
eye hemorrhage Spp1tm1.1(KOMP)Vlcg HOM   Early adult 2.55×10-05
abnormal eyelid morphology Spp1tm1.1(KOMP)Vlcg HOM   Early adult 5.78×10-06
corneal deposits Spp1tm1.1(KOMP)Vlcg HOM   Early adult 4.69×10-05
narrow eye opening Spp1tm1.1(KOMP)Vlcg HOM   Early adult 5.25×10-05
exophthalmos Spp1tm1.1(KOMP)Vlcg HOM   Early adult 5.88×10-06
corneal vascularization Spp1tm1.1(KOMP)Vlcg HOM   Early adult 4.39×10-05
eyelids fail to open Spp1tm1.1(KOMP)Vlcg HOM   Early adult 3.17×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (2/2)  Section images
Aorta 2 No  (1/583) N/A
Bone 2 No  (2/2)  Section images
Bone marrow 2 No  (2/2)  Section images
Brain 2 No  (4/583)  (2/2)  Section images
Brainstem 2 No  (2/583)  (2/2)  Section images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583)  (2/2)  Section images
Cerebellum 2 No  (3/583)  (2/2)  Section images
Cerebral cortex 2 No  (2/583)  (2/2)  Section images
Epididymis 2 No  (18/132) N/A
Esophagus 2 No  (7/407) N/A
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/583) N/A
Hippocampus 2 No  (3/583)  (2/2)  Section images
Hypothalamus 2 No  (2/583)  (2/2)  Section images
Kidney 2 No  (21/583)  (2/2)  Section images
Large intestine 2 No  (10/583) N/A
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583)  (2/2)  Section images
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/583)  (2/2)  Section images
Ovary 2 No  (1/583)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/583)  (2/2)  Section images
Peripheral nervous system 2 No  (2/583)  (2/2)  Section images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583)  (2/2)  Section images
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583)  (2/2)  Section images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583) N/A
Striatum 2 No  (3/583)  (2/2)  Section images
Submandibular gland 2 No  (2/130)  (1/2)  Section images
Testis 2 No  (6/583)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  (1/583)  (2/2)  Section images
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583) N/A
Urinary bladder 2 No N/A
Uterus 2 No  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/3) N/A
2  (1/60) Image Only N/A
2  (1/505)  (2/3) N/A
2  (1/506)  (2/3)  Wholemount images
2  (1/505)  (2/3) N/A
2  (1/505)  (1/3) N/A
2  (1/505) N/A
2  (1/505)  (1/3) N/A
2  (1/61) N/A
2  (1/505)  (1/3) N/A
2  (5/505)  (2/3) N/A
2  (1/505) N/A
2  (6/505)  (2/3) N/A
2  (1/505)  (1/3) N/A
2  (1/503) N/A
2  (1/503) Image Only N/A
2  (1/505)  (2/3) N/A
2  (1/505) Image Only N/A
2  (1/505)  (1/3) N/A
2  (1/75) N/A
2  (1/503) Image Only N/A
2  (1/505)  (1/3) N/A
2  (1/72)  (2/3) N/A
2  (1/505)  (1/3) N/A
2  (1/505) N/A

 Associated Images

Original Image
Adult LacZ: LacZ Images Section
28 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
Electroretinography 2: Rod and cone PDF
4 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
7 Images

 Disease Models

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MGI Allele Allele Type Produced
Spp1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Spp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells