Genes Phenotypes

Gene: Sptbn1

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Name
spectrin beta, non-erythrocytic 1
MGI ID
MGI:98388
Synonyms
Spnb2 Spnb-2 brain spectrin 9930031C03Rik elf1 spectrin G beta fodrin non-erythrocytic elf3
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (9) Measurements chart (176) All data table (361)
Expression & images (45) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased lactate dehydrogenase level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 8.77×10-06
decreased circulating alanine transaminase level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 6.54×10-05
decreased circulating cholesterol level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 1.38×10-07
decreased circulating serum albumin level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 1.83×10-07
decreased circulating HDL cholesterol level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 2.00×10-07
decreased circulating total protein level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 4.42×10-06
preweaning lethality, complete penetrance Sptbn1tm1a(EUCOMM)Wtsi HOM n/a 0.00
decreased circulating LDL cholesterol level Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 1.58×10-05
decreased body weight Sptbn1tm1a(EUCOMM)Wtsi HET postnatal 2.51×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No  (2/2) N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (1/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (1/2) N/A
Mammary gland 2 No N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (1/2) N/A
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
White adipose tissue 2 No  (2/2) N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Sptbn1tm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
lymph node, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peyer's patch, small intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peripheral nervous system, pituitary gland, HET, Male, WTSI

View all 28 images

Sptbn1tm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peyer's patch, small intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
thyroid gland, trachea, parathyroid gland, HET, Male, WTSI

View all 16 images

Sptbn1tm1a(EUCOMM)Wtsi
peripheral nervous system, pituitary gland, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peripheral nervous system, blood vessel, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peyer's patch, small intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
inguinal fat pad, white adipose tissue, mammary gland, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
white adipose tissue, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
lymph node, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peyer's patch, small intestine, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
skin, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
inguinal fat pad, white adipose tissue, mammary gland, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
skin, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
uterus, ovary, oviduct, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
urinary bladder, prostate gland, lower urinary tract, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
inguinal fat pad, white adipose tissue, mammary gland, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
white adipose tissue, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
urinary bladder, lower urinary tract, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
urinary bladder, prostate gland, lower urinary tract, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
kidney, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
heart, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
peripheral nervous system, blood vessel, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
thyroid gland, trachea, parathyroid gland, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
adrenal gland, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
inguinal fat pad, white adipose tissue, mammary gland, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
urinary bladder, prostate gland, lower urinary tract, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
thyroid gland, trachea, parathyroid gland, HET, Male, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
Sptbn1tm1a(EUCOMM)Wtsi
eye, HET, Male, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Sptbn1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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