Genes Phenotypes

Gene: Sparc

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Name
secreted acidic cysteine rich glycoprotein
MGI ID
MGI:98373
Synonyms
BM-40 osteonectin
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (16) Measurements chart (282) All data table (756)
Expression & images (45) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 8.52×10-07
abnormal lens morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 1.43×10-10
abnormal incisor color Sparctm1a(EUCOMM)Wtsi HOM postnatal 2.20×10-07
decreased body weight Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.26×10-09
abnormal tibia morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 4.35×10-06
abnormal humerus morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 2.25×10-05
abnormal coat/hair pigmentation Sparctm1a(EUCOMM)Wtsi HOM postnatal 1.66×10-07
increased heart weight Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.30×10-05
decreased bone mineral density Sparctm1a(EUCOMM)Wtsi HOM postnatal 5.69×10-08
increased circulating alanine transaminase level Sparctm1a(EUCOMM)Wtsi HOM postnatal 2.25×10-05
cataract Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.70×10-11
abnormal tooth morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 8.19×10-07
decreased bone mineral content Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.01×10-06
abnormal coat/ hair morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 7.70×10-06
decreased heart weight Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.30×10-05
decreased body length Sparctm1a(EUCOMM)Wtsi HOM postnatal 9.33×10-11

Download data as:  TSV  XLS

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (2/2) N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (1/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
White adipose tissue 2 No  (2/2) N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Sparctm1a(EUCOMM)Wtsi
parathyroid gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, HET, Female, WTSI

View all 29 images

Sparctm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
heart, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI

View all 15 images

Sparctm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, peyer's patch, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, peyer's patch, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lymph node, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
thymus, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
pituitary gland, peripheral nervous system, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
heart, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
skeletal muscle tissue, blood vessel, bone, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
cartilage tissue, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
adrenal gland, kidney, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
kidney, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lower urinary tract, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
parathyroid gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
adrenal gland, kidney, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
mammary gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
pinna, skin, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
uterus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
eye, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
pinna, skin, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
mammary gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
skeletal muscle tissue, blood vessel, bone, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Sparctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sparctm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Sparctm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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