Gene: Sparc

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secreted acidic cysteine rich glycoprotein
BM-40 osteonectin
Other links
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased body weight Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.26×10-09
abnormal eye morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 8.52×10-07
abnormal lens morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 1.43×10-10
abnormal incisor color Sparctm1a(EUCOMM)Wtsi HOM postnatal 2.20×10-07
abnormal humerus morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 2.25×10-05
abnormal tibia morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 4.35×10-06
abnormal coat/hair pigmentation Sparctm1a(EUCOMM)Wtsi HOM postnatal 1.66×10-07
increased heart weight Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.30×10-05
decreased bone mineral density Sparctm1a(EUCOMM)Wtsi HOM postnatal 5.69×10-08
abnormal coat/ hair morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 7.70×10-06
increased circulating alanine transaminase level Sparctm1a(EUCOMM)Wtsi HOM postnatal 2.25×10-05
cataract Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.70×10-11
decreased bone mineral content Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.01×10-06
abnormal tooth morphology Sparctm1a(EUCOMM)Wtsi HOM postnatal 8.19×10-07
decreased heart weight Sparctm1a(EUCOMM)Wtsi HOM postnatal 3.30×10-05
decreased body length Sparctm1a(EUCOMM)Wtsi HOM postnatal 9.33×10-11

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Select physiological systems to view:
Viewing: all phenotypes


IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (2/2) N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (1/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
White adipose tissue 2 No  (2/2) N/A
LacZ Section Images

View all 29 images

View all 15 images

No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Sparctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sparctm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Sparctm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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