Genes Phenotypes

Gene: Sparc

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Name
secreted acidic cysteine rich glycoprotein
MGI ID
MGI:98373
Synonyms
osteonectin BM-40
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (14) Measurements chart (261) All data table (459)
Expression & images (45) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal incisor color Sparctm1a(EUCOMM)Wtsi HOM Early adult 5.12×10-09
decreased bone mineral content Sparctm1a(EUCOMM)Wtsi HOM Early adult 2.55×10-06
decreased heart weight Sparctm1a(EUCOMM)Wtsi HOM Early adult 3.30×10-05
abnormal coat/ hair morphology Sparctm1a(EUCOMM)Wtsi HOM Early adult 7.70×10-06
decreased body length Sparctm1a(EUCOMM)Wtsi HOM Early adult 4.21×10-11
increased heart weight Sparctm1a(EUCOMM)Wtsi HOM Early adult 3.30×10-05
abnormal coat/hair pigmentation Sparctm1a(EUCOMM)Wtsi HOM Early adult 1.66×10-07
cataract Sparctm1a(EUCOMM)Wtsi HOM Early adult 1.29×10-12
decreased bone mineral density Sparctm1a(EUCOMM)Wtsi HOM Early adult 7.85×10-08
decreased lean body mass Sparctm1a(EUCOMM)Wtsi HOM Early adult 5.22×10-05
abnormal eye morphology Sparctm1a(EUCOMM)Wtsi HOM Early adult 1.15×10-07
abnormal lens morphology Sparctm1a(EUCOMM)Wtsi HOM Early adult 2.85×10-12
decreased body weight Sparctm1a(EUCOMM)Wtsi HOM Early adult 3.55×10-05
decreased mean corpuscular hemoglobin concentration Sparctm1a(EUCOMM)Wtsi HOM Early adult 1.19×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (2/2) N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (1/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
White adipose tissue 2 No  (2/2) N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Sparctm1a(EUCOMM)Wtsi
parathyroid gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI

View all 29 images

Sparctm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, HET, Female, WTSI

View all 15 images

Sparctm1a(EUCOMM)Wtsi
gall bladder, liver, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, peyer's patch, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
small intestine, peyer's patch, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
thymus, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
lymph node, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
pituitary gland, peripheral nervous system, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
skeletal muscle tissue, blood vessel, bone, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
heart, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
cartilage tissue, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
adrenal gland, kidney, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
kidney, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lower urinary tract, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
white adipose tissue, blood vessel, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
parathyroid gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
adrenal gland, kidney, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
pinna, skin, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
mammary gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
uterus, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
eye, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
pinna, skin, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
mammary gland, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
skeletal muscle tissue, blood vessel, bone, HET, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Sparctm1a(EUCOMM)Wtsi
head, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
body, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
body, WT, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
head, WT, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
body, HOM, Male, WTSI

View all 154 images

Sparctm1a(EUCOMM)Wtsi
eye, cataracts, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
eye, cataracts, HOM, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
eye, cataracts, HOM, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
eye, cataracts, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
eye, exophthalmos, cataracts, HOM, Female, WTSI

View all 20 images

Sparctm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
brain, megacephaly, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
megacephaly, brain, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Sparctm1a(EUCOMM)Wtsi
abnormal incisor color, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
abnormal incisor color, lower jaw incisor, HOM, Male, WTSI
Sparctm1a(EUCOMM)Wtsi
abnormal incisor color, HOM, Male, WTSI

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Sparctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sparctm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Sparctm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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