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Genes Phenotypes Help, News, Blog

Gene: Shh

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Name
sonic hedgehog
MGI ID
MGI:98297
Synonyms
Hhg1
Viability
Data available
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (275) All data table (794)
Expression & images (67) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating HDL cholesterol level Shhtm1b(EUCOMM)Wtsi HET Early adult 8.99×10-07
impaired glucose tolerance Shhtm1b(EUCOMM)Wtsi HET Early adult 4.59×10-05
increased total body fat amount Shhtm1b(EUCOMM)Wtsi HET Early adult 1.73×10-09
limb grasping Shhtm1Chg HET Early adult 5.19×10-05
decreased lean body mass Shhtm1b(EUCOMM)Wtsi HET Early adult 3.81×10-08
increased circulating cholesterol level Shhtm1b(EUCOMM)Wtsi HET Early adult 1.44×10-05
preweaning lethality, complete penetrance Shhtm1b(EUCOMM)Wtsi HOM   Early adult 0.00
decreased bone mineral content Shhtm1b(EUCOMM)Wtsi HET Early adult 2.41×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (1/2)  Wholemount images
Aorta 2 No  (1/583) N/A
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/583)  (2/2)  Wholemount images
Esophagus 2 No  (7/407)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/583) N/A
Hippocampus 2 No  (3/583)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/583)  (2/2)  Wholemount images
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583)  (2/2)  Wholemount images
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/583) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563) N/A
Peripheral nervous system 2 No  (2/583)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583)  (2/2)  Wholemount images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Wholemount images
Striatum 2 No  (3/583)  (2/2)  Wholemount images
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583)  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (4)
Gall Bladder expression
MA:0000356
endocrine system (1)
Adrenal gland expression
MA:0000116
nervous system (5)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (15)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
respiratory system (3)
Lung expression
MA:0000415
trunk (9)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (3/5) N/A
2  (1/505)  (1/5) N/A
2  (1/506)  (5/5) N/A
2  (1/505) N/A
2  (1/505)  (3/5) N/A
2  (1/505)  (2/5) N/A
2  (1/505) N/A
2  (1/505)  (3/5) N/A
2  (5/505)  (5/5) N/A
2  (1/505) N/A
2  (6/505)  (2/5) N/A
2  (1/505) N/A
2  (1/503) N/A
2  (1/503)  (2/5) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505)  (3/5) N/A
2  (1/503)  (1/5) N/A
2  (1/505) N/A
2  (1/505)  (3/5) N/A
2  (1/505) N/A

 Associated Images

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Echo: M-Mode Images
32 Images
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Adult LacZ: LacZ Images Wholemount
15 Images
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Embryo LacZ: LacZ images wholemount
12 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
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X-ray: XRay Images Whole Body Lateral Orientation
10 Images
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X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Shhtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Shhtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Shhtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Shhtm39984(L1L2_st0) Targeting vectors