Genes Phenotypes

Gene: Shh

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Name
sonic hedgehog
MGI ID
MGI:98297
Synonyms
Hhg1
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (295) All data table (794)
Expression & images (67) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal circulating cholesterol level Shhtm1b(EUCOMM)Wtsi HET Early adult 1.44×10-05
preweaning lethality, complete penetrance Shhtm1b(EUCOMM)Wtsi HOM Early adult 0.00
decreased lean body mass Shhtm1b(EUCOMM)Wtsi HET Early adult 3.82×10-08
abnormal circulating HDL cholesterol level Shhtm1b(EUCOMM)Wtsi HET Early adult 1.12×10-06
impaired glucose tolerance Shhtm1b(EUCOMM)Wtsi HET Early adult 4.76×10-05
limb grasping Shhtm1Chg HET Early adult 5.72×10-09
increased total body fat amount Shhtm1b(EUCOMM)Wtsi HET Early adult 1.73×10-09
decreased bone mineral content Shhtm1b(EUCOMM)Wtsi HET Early adult 2.42×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589)  (1/2)  Wholemount images
Aorta 2 No  (1/589) N/A
Bone 2 No N/A
Brain 2 No  (3/589)  (2/2)  Wholemount images
Brainstem 2 No  (2/589)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/589)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/589)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/589) N/A
Hippocampus 2 No  (3/589)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/589)  (2/2)  Wholemount images
Kidney 2 No  (20/589)  (2/2)  Wholemount images
Large intestine 2 No  (10/589)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/589)  (2/2)  Wholemount images
Lung 2 No  (1/589)  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/589)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/589) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/589) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/589)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/589) N/A
Spinal cord 2 No  (2/589)  (2/2)  Wholemount images
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589)  (2/2)  Wholemount images
Striatum 2 No  (3/589)  (2/2)  Wholemount images
Testis 2 No  (5/589)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/589) N/A
Trachea 2 No  (2/589)  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (22)
Esophagus expression
Stomach
digestive system (3)
Gall Bladder expression
MA:0000356
endocrine system (1)
Adrenal gland expression
MA:0000116
nervous system (2)
Peripheral Nervous System expression
MA:0000218
postnatal mouse (11)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
respiratory system (3)
Lung expression
MA:0000415
trunk (8)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (3/5) N/A
Ear 2  (1/506)  (1/5) N/A
Embryo 2  (1/507)  (5/5) N/A
Eye 2  (1/506) N/A
Foot 2  (1/506)  (3/5) N/A
Forebrain 2  (1/506)  (2/5) N/A
Forelimb 2  (1/506) N/A
Hand 2  (1/505)  (3/5) N/A
Head 2  (5/506)  (5/5) N/A
Heart 2  (1/506) N/A
Hindbrain 2  (6/506)  (2/5) N/A
Hindlimb 2  (1/505) N/A
Liver 2  (1/506) N/A
Lung 2  (1/502)  (2/5) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506)  (3/5) N/A
Oral cavity 2  (1/506)  (1/5) N/A
Skin 2  (1/506) N/A
Tail 2  (1/506)  (3/5) N/A
Tail somite 2  (1/506) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
33 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Embryo LacZ: LacZ images wholemount
12 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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MGI Allele Allele Type Produced
Shhtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Shhtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Shhtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Shhtm39984(L1L2_st0) Targeting vectors