Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Shhtm1b(EUCOMM)Wtsi HOM   Early adult 0.00
decreased lean body mass Shhtm1b(EUCOMM)Wtsi HET Early adult 3.74×10-08
increased circulating cholesterol level Shhtm1b(EUCOMM)Wtsi HET Early adult 1.37×10-05
limb grasping Shhtm1Chg HET Early adult 5.19×10-05
increased total body fat amount Shhtm1b(EUCOMM)Wtsi HET Early adult 3.17×10-09
impaired glucose tolerance Shhtm1b(EUCOMM)Wtsi HET Early adult 7.43×10-05
decreased bone mineral content Shhtm1b(EUCOMM)Wtsi HET Early adult 2.42×10-05
increased circulating HDL cholesterol level Shhtm1b(EUCOMM)Wtsi HET Early adult 8.84×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/556)  (1/2)  Wholemount images
Aorta 2 No  (1/557) N/A
Bone 2 No N/A
Brain 2 No  (4/564)  (2/2)  Wholemount images
Brainstem 2 No  (2/555)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/567) N/A
Cerebellum 2 No  (3/559)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/559)  (2/2)  Wholemount images
Esophagus 2 No  (7/393)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/546) N/A
Hippocampus 2 No  (3/556)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/557)  (2/2)  Wholemount images
Kidney 2 No  (21/561)  (2/2)  Wholemount images
Large intestine 2 No  (10/556)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/555)  (2/2)  Wholemount images
Lung 2 No  (2/556)  (2/2)  Wholemount images
Lymph node 2 No  (1/561) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/552)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/558) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/555) N/A
Parathyroid gland 2 No  (1/529) N/A
Peripheral nervous system 2 No  (2/550)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/565) N/A
Prostate gland 2 No  (12/550) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/558) N/A
Small intestine 2 No  (9/558) N/A
Spinal cord 2 No  (3/552)  (2/2)  Wholemount images
Spleen 2 No  (2/563) N/A
Stomach 2 No  (12/556)  (2/2)  Wholemount images
Striatum 2 No  (3/554)  (2/2)  Wholemount images
Testis 2 No  (6/552)  (1/2)  Wholemount images
Thymus 2 No  (1/551) N/A
Thyroid gland 2 No  (16/554) N/A
Trachea 2 No  (3/556)  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (4/320)  (3/5) N/A
Ear 2  (1/341)  (1/5) N/A
Embryo 2  (1/316)  (5/5) N/A
Eye 2 N/A
Footplate 2  (1/327)  (3/5) N/A
Forebrain 2  (2/5) N/A
Forelimb 2  (1/335) N/A
Handplate 2  (3/5) N/A
Head 2  (5/326)  (5/5) N/A
Heart 2  (1/333) N/A
Hindbrain 2  (4/330)  (2/5) N/A
Hindlimb 2  (1/329) N/A
Liver 2  (1/319) N/A
Lung 2  (1/350)  (2/5) N/A
Mandibular process 2  (1/330) N/A
Maxillary process 2  (1/335) N/A
Midbrain 2  (1/322)  (3/5) N/A
Oral cavity 2  (1/5) N/A
Skin 2 N/A
Tail 2  (3/5) N/A
Tail somite group 2  (1/345) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
15 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Shhtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Shhtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Shhtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Shhtm39984(L1L2_st0) Targeting vectors