Gene: Rfc1

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Name
replication factor C (activator 1) 1
MGI ID
MGI:97891
Synonyms
RFC140 Alp145 140kDa Recc1
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating HDL cholesterol level Rfc1tm1b(KOMP)Mbp HET Early adult 6.04×10-08
decreased circulating insulin level Rfc1tm1b(KOMP)Mbp HET   Early adult 6.70×10-05
embryonic growth retardation Rfc1tm1b(KOMP)Mbp HET E9.5 0.00
abnormal embryo size Rfc1tm1b(KOMP)Mbp HET E9.5 0.00
abnormal embryo turning Rfc1tm1b(KOMP)Mbp HET E9.5 0.00
preweaning lethality, complete penetrance Rfc1tm1b(KOMP)Mbp HOM   Early adult 0.00
increased circulating cholesterol level Rfc1tm1b(KOMP)Mbp HET Early adult 3.02×10-06
embryonic lethality prior to organogenesis Rfc1tm1b(KOMP)Mbp HOM   E9.5 0.00
decreased circulating triglyceride level Rfc1tm1b(KOMP)Mbp HET Early adult 4.59×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (2/2)  Section images
Aorta 2 No  (1/583)  (2/2)  Section images
Bone 1 No  (1/1) N/A
Bone marrow 2 No N/A
Brain 2 No  (4/583) N/A
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Epididymis 2 No  (18/132) N/A
Esophagus 2 No  (7/407)  (2/2)  Section images
Eye 2 No N/A
Heart 2 No  (2/583)  (2/2)  Section images
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583)  (2/2)  Section images
Large intestine 2 No  (10/583)  (2/2)  Section images
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583)  (2/2)  Section images
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No  (2/583) N/A
Ovary 2 No  (1/583)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/583)  (2/2)  Section images
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583)  (1/2)  Section images
Prostate gland 2 No  (12/583) N/A
Quadriceps 1 No N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583)  (2/2)  Section images
Spinal cord 2 No  (3/583) N/A
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Section images
Striatum 2 No  (3/583) N/A
Submandibular gland 2 No  (2/130)  (2/2)  Section images
Testis 2 No  (6/583)  (1/2)  Section images
Thalamus 2 No N/A
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583) N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
1  (6/505) N/A
1  (1/60) N/A
1  (1/505) N/A
1  (1/506) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/61) N/A
1  (1/505) N/A
1  (5/505) N/A
1  (1/505) N/A
1  (6/505) N/A
1  (1/505) N/A
1  (1/503) N/A
1  (1/503) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/505) N/A
1  (1/75) N/A
1  (1/503) N/A
1  (1/505) N/A
1  (1/72) N/A
1  (1/505) N/A
1  (1/505) N/A

 Associated Images

X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
Original Image
Adult LacZ: LacZ Images Section
18 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
Eye Morphology: Images Ophthalmoscopy
3 Images
Eye Morphology: Images Slit Lamp
1 Images

 Disease Models

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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rfc1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rfc1tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice

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