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Gene: Rad51 MGI:97890

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
RAD51 recombinase
Synonyms:
Rad51a,  Reca

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rad51 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rad51 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fanconi Anemia
Intrauterine growth retardation, Patent ductus arteriosus, Spina bifida, Umbilical hernia ORPHA:84
Familial Congenital Mirror Movements
ORPHA:238722
Hereditary Breast And/Or Ovarian Cancer Syndrome
ORPHA:145
Breast Cancer
OMIM:114480
Fanconi Anemia, Complementation Group R
OMIM:617244
Mirror Movements 2
OMIM:614508

The table below shows human diseases predicted to be associated to Rad51 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fanconi Anemia
Intrauterine growth retardation, Patent ductus arteriosus, Spina bifida, Umbilical hernia ORPHA:84
Familial Congenital Mirror Movements
ORPHA:238722
Hereditary Breast And/Or Ovarian Cancer Syndrome
ORPHA:145
Breast Cancer
OMIM:114480
Fanconi Anemia, Complementation Group R
OMIM:617244
Mirror Movements 2
OMIM:614508

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rad51

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rad51.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. Molecular cancer research : MCR (June 2021) Rad51ap1tm1.1(KOMP)Vlcg 34099522
RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal. Cancer research (July 2020) Rad51ap1tm1.1(KOMP)Vlcg 32665355

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Rad51tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rad51tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Rad51tm373982(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Rad51tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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