Gene: Slc20a2

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased body length Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 1.10×10-12
abnormal spine curvature Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 6.78×10-07
decreased lean body mass Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 3.24×10-09
increased grip strength Slc20a2tm1a(EUCOMM)Wtsi HET Early adult 7.07×10-06
abnormal lens morphology Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 5.55×10-13
impaired glucose tolerance Slc20a2tm1b(EUCOMM)Wtsi HET Early adult 3.72×10-07
abnormal bone structure Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 4.90×10-08
increased circulating alkaline phosphatase level Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 1.49×10-08
eyelids fail to open Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 5.70×10-05
increased circulating magnesium level Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 8.93×10-05
narrow eye opening Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 1.23×10-05
decreased bone mineral density Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 1.97×10-07
irregularly shaped pupil Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 1.39×10-05
preweaning lethality, incomplete penetrance Slc20a2tm1b(EUCOMM)Wtsi HOM Early adult 0.00799
cataract Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 5.55×10-13
absent pinna reflex Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 2.14×10-06
abnormal incisor color Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 3.25×10-11
abnormal vocalization Slc20a2tm1b(EUCOMM)Wtsi HET Early adult 2.26×10-05
decreased bone mineral content Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 5.08×10-09
kyphosis Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 5.84×10-08
abnormal iris morphology Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 3.60×10-09
decreased total body fat amount Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 1.80×10-06
decreased fasting circulating glucose level Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult 8.04×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood 2 No N/A
Bone 2 No N/A
Bone marrow 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127) N/A
Cranium 2 No N/A
Diaphragm 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Harderian gland 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Main olfactory bulb 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  Wholemount images
Oviduct 2 No N/A
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No N/A
Parotid gland 2 No  Wholemount images
Penis 2 No  (1/2)  Wholemount images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Sciatic nerve 2 No N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (1/2)  Wholemount images
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No  Wholemount images
Submandibular gland 2 No  (2/132)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Tongue 2 No  (5/127) N/A
Trachea 2 No N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No  Wholemount images
Vagina 2 No N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Adult LacZ: LacZ Images Wholemount
15 Images
X-ray: XRay Images Whole Body Lateral Orientation
66 Images
X-ray: XRay Images Whole Body Dorso Ventral
93 Images
X-ray: XRay Images Forepaw
24 Images
X-ray: XRay Images Skull Lateral Orientation
25 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
27 Images
X-ray: XRay Images Hind Leg and Hip
1 Images
Legacy Phenotype Associated Images

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 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Sternum - developmental and structural abnormality Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult
Brain - mineralisation Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult
Eye with optic nerve - developmental dysplasia Slc20a2tm1a(EUCOMM)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Slc20a2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Slc20a2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Slc20a2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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