Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

protein tyrosine phosphatase, receptor type, G
RPTPgamma,  5430405N12Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ptprg mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ptprg by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Intellectual Developmental Disorder, Autosomal Recessive 59
Aggressive behavior OMIM:617323
Schizophrenia 15
Hyperactivity OMIM:613950
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
Panic Disorder 1
Anxiety OMIM:167870
Autism, Susceptibility To, X-Linked 4
Impulsivity, Aggressive behavior, Attention deficit hyperactivity disorder OMIM:300830
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Familial Alzheimer-Like Prion Disease
Cognitive impairment, Deficit in phonologic short-term memory, Emotional lability, Depression, An... ORPHA:280397
Severe Primary Trimethylaminuria
Aggressive behavior, Anxiety, Emotional lability, Low self esteem, Depression, Negative affectivity ORPHA:468726
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Chorea, Inappropriate behavior, Memory impairment, Cognitive impairment, Ataxia, Tremor, Depressi... ORPHA:401901
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Basal Ganglia Calcification, Idiopathic, 5
Chorea, Cognitive impairment, Apathy, Dementia, Depression, Anxiety, Athetosis OMIM:615483
Intellectual Developmental Disorder, Autosomal Recessive 2
Attention deficit hyperactivity disorder, Self-injurious behavior OMIM:607417
Dystonia 11, Myoclonic
Writer's cramp, Torticollis, Tremor, Depression, Anxiety, Agoraphobia, Panic attack OMIM:159900
Huntington Disease-Like 2
Chorea, Memory impairment, Inertia, Anxiety, Apathy, Dementia, Action tremor, Depression, Subcort... OMIM:606438
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Spinocerebellar Ataxia 12
Dysdiadochokinesis, Dementia, Dysmetria, Head tremor, Axial dystonia, Action tremor, Depression, ... OMIM:604326
Chorea, Benign Hereditary
Chorea, Dementia, Anxiety OMIM:118700
Smith-Magenis syndrome
Hyperactivity, Self-mutilation DECIPHER:8
Sandhoff Disease, Adult Form
Gait ataxia, Anxiety, Focal dystonia, Tremor, Mental deterioration, Dystonia ORPHA:309169
Childhood-Onset Benign Chorea With Striatal Involvement
Chorea, Dementia, Anxiety ORPHA:494541
Myoclonus-Dystonia Syndrome
Anxiety, Writer's cramp, Torticollis, Depression, Panic attack, Dystonia, Personality disorder ORPHA:36899
Creutzfeldt-Jakob Disease
Gait ataxia, Apathy, Dementia, Depression, Anxiety, Irritability, Memory impairment OMIM:123400
Gilles De La Tourette Syndrome
Aggressive behavior, Attention deficit hyperactivity disorder, Self-mutilation OMIM:137580
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity, Aggressive behavior, Self-injurious behavior, Anxiety OMIM:619031
Obsessive-Compulsive Disorder
Skin-picking, Depression, Anxiety OMIM:164230
Parkinson Disease 6, Autosomal Recessive Early-Onset
Resting tremor, Dementia, Depression, Anxiety, Dystonia OMIM:605909
Persistent Idiopathic Facial Pain
Somatic sensory dysfunction, Paresthesia, Impaired pain sensation, Depression, Anxiety ORPHA:398147
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Aggressive behavior OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Aggressive behavior ORPHA:356996
Spinocerebellar Ataxia 48
Gait ataxia, Chorea, Anxiety, Ataxia, Dysmetria, Tremor, Depression, Mental deterioration, Irrita... OMIM:618093
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Epilepsy, Progressive Myoclonic, 12
Ataxia, Dysmetria, Depression, Anxiety, Mental deterioration OMIM:619191
Spinocerebellar Ataxia 14
Gait ataxia, Impaired vibration sensation at ankles, Focal dystonia, Dysmetria, Depression, Menta... OMIM:605361
Huntington Disease-Like 1
Chorea, Aggressive behavior, Dementia, Dysmetria, Depression, Anxiety OMIM:603218
Intellectual Developmental Disorder, Autosomal Recessive 54
Exaggerated startle response, Emotional lability OMIM:617028
Rapid-Onset Dystonia-Parkinsonism
Gait ataxia, Resting tremor, Limb dystonia, Torticollis, Emotional lability, Craniofacial dystoni... ORPHA:71517
Intellectual Developmental Disorder, X-Linked 63
Anxiety OMIM:300387
Migraine, Familial Hemiplegic, 1
Tremor, Ataxia, Anxiety OMIM:141500
Dystonia 12
Torticollis, Emotional lability, Tremor, Depression, Anxiety, Dystonia OMIM:128235
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity OMIM:616311
Progressive Supranuclear Palsy-Parkinsonism Syndrome
Memory impairment, Anxiety, Apathy, Tremor, Depression, Mental deterioration, Dystonia ORPHA:240085
Gm2 Gangliosidosis, Ab Variant
Chorea, Inappropriate behavior, Exaggerated startle response, Abnormal fear/anxiety-related behav... ORPHA:309246
Developmental And Epileptic Encephalopathy 104
Hyperactivity, Self-injurious behavior, Agitation OMIM:619970
Hartnup Disorder
Hyperactivity, Attention deficit hyperactivity disorder, Emotional lability OMIM:234500
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Glycine Encephalopathy
Hyperactivity, Aggressive behavior, Impulsivity, Irritability, Restlessness OMIM:605899
Early-Onset Schizophrenia
Diminished motivation, Abnormal emotion/affect behavior, Suicidal ideation, Unhappy demeanor, Emo... ORPHA:96369
Dystonia 26, Myoclonic
Blepharospasm, Anxiety, Torticollis, Depression, Laryngeal dystonia, Dystonia OMIM:616398
Chorea, Abnormal fear/anxiety-related behavior, Separation insecurity, Emotional lability, Depres... ORPHA:66624
Intellectual Developmental Disorder, X-Linked 109
Impulsivity, Hyperactivity, Aggressive behavior, Agitation OMIM:309548
Geniospasm 1
Anxiety OMIM:190100
Neurodevelopmental Disorder With Hyperkinetic Movements And Dyskinesia
Tremor, Dystonia, Anxiety OMIM:619651
Childhood Disintegrative Disorder
Abnormal emotion/affect behavior, Social and occupational deterioration, Anxiety, Motor deteriora... ORPHA:168782
Fraxe Intellectual Disability
Hyperactivity, Impulsivity, Aggressive behavior, Agitation ORPHA:100973
Paresthesia, Depression, Anxiety ORPHA:770
Raynaud-Claes Syndrome
Aggressive behavior, Bipolar affective disorder, Depression, Anxiety, Progressive cerebellar atax... OMIM:300114
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Impulsivity, Hyperactivity, Attention deficit hyperactivity disorder OMIM:301008
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Inappropriate behavior, Frontotemporal dementia, Inertia, Motor deterioration, Apathy, Dementia, ... ORPHA:412066
Mannosidosis, Beta A, Lysosomal
Hyperactivity, Aggressive behavior OMIM:248510
Posttransplant Acute Limbic Encephalitis
Cognitive impairment, Ataxia, Dystonia, Depression, Anxiety, Memory impairment ORPHA:163921
Hyperprolinemia, Type I
Hyperactivity, Aggressive behavior OMIM:239500
Parkinsonism With Polyneuropathy
Depression, Resting tremor, Anxiety OMIM:619279
Fragile X Tremor/Ataxia Syndrome
Gait ataxia, Impaired distal vibration sensation, Dysdiadochokinesis, Postural tremor, Resting tr... OMIM:300623
Parkinsonism-Dystonia 3, Childhood-Onset
Chorea, Aggressive behavior, Ataxia, Tremor, Action tremor, Depression, Anxiety, Dystonia OMIM:619738
Trisomy X
Tremor, Cognitive impairment, Depression, Anxiety ORPHA:3375
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Abnormal aggressive, impulsive or vi... ORPHA:3077
Parkinson Disease 7, Autosomal Recessive Early-Onset
Blepharospasm, Resting tremor, Postural tremor, Leg dystonia, Anxiety OMIM:606324
Developmental And Epileptic Encephalopathy 43
Impulsivity, Hyperactivity, Attention deficit hyperactivity disorder OMIM:617113
Stiff Person Spectrum Disorder
Agoraphobia, Exaggerated startle response, Emotional lability, Anxiety ORPHA:3198
Progressive choreoathetosis, Aggressive behavior, Dementia, Emotional lability, Self-mutilation o... OMIM:200150
Tay-Sachs Disease
Exaggerated startle response, Apathy, Psychomotor deterioration, Dementia OMIM:272800
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear/anxiety-related behavior, Aggressive behavior, Suicidal ideation ORPHA:208441
Hyperactivity, Aggressive behavior, Attention deficit hyperactivity disorder, Anxiety, Irritabili... OMIM:261600
Posterior Cortical Atrophy
Memory impairment, Inertia, Ataxia, Anxiety ORPHA:54247
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Gait ataxia, Diminished motivation, Aggressive behavior, Cognitive impairment, Dysdiadochokinesis... OMIM:615157
Dystonia 28
Anxiety, Torticollis, Leg dystonia, Oromandibular dystonia, Depression, Arm dystonia, Generalized... ORPHA:589618
Morm Syndrome
Hyperactivity, Aggressive behavior ORPHA:75858
Developmental And Epileptic Encephalopathy 56
Action tremor, Ataxia, Anxiety OMIM:617665
Mitochondrial Dna Depletion Syndrome 16B (Neuroophthalmic Type)
Depression, Ataxia, Anxiety OMIM:619425
Neurodevelopmental Disorder With Dystonia And Seizures
Chorea, Self-injurious behavior, Anxiety, Athetosis, Dystonia OMIM:619922
Wolfram-Like Syndrome
Depression, Progressive cerebellar ataxia, Dementia, Anxiety ORPHA:411590
Dyskinesia With Orofacial Involvement, Autosomal Dominant
Chorea, Resting tremor, Choreoathetosis, Anxiety, Dystonia OMIM:606703
Chromosome 3Q29 Deletion Syndrome
Hyperactivity, Aggressive behavior, Anxiety OMIM:609425
Huntington Disease
Chorea, Hostility, Aggressive behavior, Suicidal ideation, Anxiety, Apathy, Dystonia, Depression,... ORPHA:399
Inherited Creutzfeldt-Jakob Disease
Gait ataxia, Chorea, Apathy, Dementia, Emotional lability, Tremor, Progressive forgetfulness, Dep... ORPHA:282166
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Hyperactivity, Aggressive behavior, Self-injurious behavior, Self-biting, Attention deficit hyper... OMIM:619827
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Aggressive behavior, Impulsivity, Anxiety, Abnormal eating behavior ORPHA:101039
Dopa-Responsive Dystonia
Oculogyric crisis, Irritability, Emotional lability, Leg dystonia, Tremor, Depression, Anxiety, A... ORPHA:255
Guanidinoacetate Methyltransferase Deficiency
Hyperactivity, Aggressive behavior, Self-injurious behavior ORPHA:382
Perry Syndrome
Inappropriate behavior, Frontotemporal dementia, Suicidal ideation, Apathy, Tremor, Depression, A... OMIM:168605
Gm2-Gangliosidosis, Ab Variant
Chorea, Exaggerated startle response, Apathy, Dementia, Dystonia OMIM:272750
Rolandic Epilepsy
Paresthesia, Emotional lability, Dysesthesia, Depression, Anxiety ORPHA:1945
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Ataxia, Anxiety OMIM:618970
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity, Aggressive behavior, Attention deficit hyperactivity disorder, Anxiety OMIM:301013
Neurodevelopmental Disorder With Eye Movement Abnormalities And Ataxia
Dystonia, Ataxia, Anxiety OMIM:620094
Neurodevelopmental Disorder With Or Without Variable Movement Or Behavioral Abnormalities
Chorea, Resting tremor, Ataxia, Anxiety, Dystonia, Intention tremor, Panic attack OMIM:619725
Lennox-Gastaut Syndrome
Hyperactivity, Aggressive behavior ORPHA:2382
Neurodegeneration With Brain Iron Accumulation 5
Aggressive behavior, Anxiety, Dementia, Tremor, Mental deterioration, Dystonia OMIM:300894
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Adult-Onset Cervical Dystonia, Dyt23 Type
Writer's cramp, Torticollis, Focal dystonia, Head tremor, Axial dystonia, Craniofacial dystonia, ... ORPHA:420492
Landau-Kleffner Syndrome
Gait ataxia, Aggressive behavior, Social and occupational deterioration, Emotional lability, Depr... ORPHA:98818
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity OMIM:301076
Adiposis Dolorosa
Depression, Anxiety OMIM:103200
Trigeminal Neuralgia
Somatic sensory dysfunction, Episodic paroxysmal anxiety, Paresthesia, Allodynia, Depression ORPHA:221091
Generalized Epilepsy With Febrile Seizures-Plus
Tremor, Cognitive impairment, Ataxia, Anxiety ORPHA:36387
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Aggressive behavior OMIM:615541
Multiple System Atrophy, Parkinsonian Type
Gait ataxia, Resting tremor, Postural tremor, Apathy, Axial dystonia, Depression, Anxiety, Progre... ORPHA:98933
Cln5 Disease
Aggressive behavior, Dysdiadochokinesis, Anxiety, Truncal ataxia, Ataxia, Dysmetria, Tremor, Ment... ORPHA:228360
Usmani-Riazuddin Syndrome, Autosomal Dominant
Hyperactivity, Aggressive behavior, Self-injurious behavior, Anxiety OMIM:619467
Succinic Semialdehyde Dehydrogenase Deficiency
Hyperactivity, Aggressive behavior, Self-injurious behavior, Anxiety OMIM:271980
Stiff-Person Syndrome
Exaggerated startle response, Depression, Anxiety, Agoraphobia, Opisthotonus OMIM:184850
Multiple System Atrophy, Cerebellar Type
Gait ataxia, Postural tremor, Resting tremor, Apathy, Limb ataxia, Axial dystonia, Depression, An... ORPHA:227510
Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Cognitive impairment, Motor deterioration, Apathy, Dementia, Emotional lability, Depression, Anxi... ORPHA:136
Usher Syndrome Type 3
Depression, Ataxia, Anxiety ORPHA:231183
Young-Onset Parkinson Disease
Cognitive impairment, Frontal lobe dementia, Apathy, Dementia, Tremor, Depression, Anxiety, Dysto... ORPHA:2828
Aromatic L-Amino Acid Decarboxylase Deficiency
Exaggerated startle response, Blepharospasm, Limb dystonia, Torticollis, Choreoathetosis, Oculogy... OMIM:608643
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Aggressive behavior, Self-mutilation OMIM:615516
Neurodevelopmental Disorder With Central And Peripheral Motor Dysfunction
Aggressive behavior, Dysdiadochokinesis, Ataxia, Dysmetria, Anxiety, Intention tremor OMIM:618356
Intellectual Developmental Disorder, X-Linked 30
Hyperactivity, Aggressive behavior, Agitation, Anxiety, Restlessness OMIM:300558
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Hyperactivity, Aggressive behavior OMIM:612716
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Cognitive impairment, Paroxysmal dystonia, Suicidal ideation, Depression, Anxiety ORPHA:98784
Cln3 Disease
Aggressive behavior, Anxiety, Dementia, Ataxia, Depression, Mental deterioration, Memory impairment ORPHA:228346
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
Leukodystrophy, Hypomyelinating, 13
Exaggerated startle response, Irritability, Ataxia OMIM:616881
Graves Disease, Susceptibility To, 1
Hyperactivity, Irritability, Polyphagia OMIM:275000
Autosomal Dominant Dopa-Responsive Dystonia
Gait ataxia, Impaired vibration sensation in the lower limbs, Postural tremor, Limb dystonia, Tor... ORPHA:98808
Developmental Delay, Language Impairment, And Ocular Abnormalities
Impulsivity, Aggressive behavior, Attention deficit hyperactivity disorder, Hyperactivity OMIM:620141
Fragile X-Associated Tremor/Ataxia Syndrome
Gait ataxia, Inertia, Ataxia, Dementia, Dysmetria, Dysesthesia, Depression, Anxiety, Memory impai... ORPHA:93256
Burning Mouth Syndrome
Emotional lability, Dysesthesia, Impaired temperature sensation, Depression, Anxiety ORPHA:353253
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures
Hyperactivity, Aggressive behavior, Self-injurious behavior OMIM:620023
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 5
Gait ataxia, Depression, Ataxia, Anxiety OMIM:613077
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity, Aggressive behavior ORPHA:85327
Adult-Onset Distal Myopathy Due To Vcp Mutation
Dementia, Tremor, Progressive neurologic deterioration, Depression, Anxiety ORPHA:329478
Fatty Acid Hydroxylase-Associated Neurodegeneration
Anxiety, Progressive gait ataxia, Bipolar affective disorder, Depression, Mental deterioration, G... ORPHA:329308
Myopathy, Mitochondrial, And Ataxia
Dysdiadochokinesis, Truncal ataxia, Limb ataxia, Ataxia, Dysmetria, Tremor, Depression, Anxiety, ... OMIM:617675
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Impaired vibration sensation in the lower limbs, Exaggerated startle response ORPHA:320406
Mcleod Syndrome
Chorea, Impaired vibration sensation at ankles, Depression, Anxiety, Dystonia, Personality disorder OMIM:300842
Neurodevelopmental Disorder With Speech Impairment And With Or Without Seizures
Exaggerated startle response, Depression OMIM:620114
Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities
Chorea, Exaggerated startle response, Irritability OMIM:617864
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response, Ataxia OMIM:618598
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Exaggerated startle response, Dystonia, Ataxia, Anxiety ORPHA:438216
Paresthesia, Abnormality of pain sensation, Tremor, Anxiety, Transient global amnesia ORPHA:97279
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity, Self-biting OMIM:618314
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
Gait ataxia, Exaggerated startle response, Truncal titubation, Dysmetria, Tremor OMIM:618056
Autoimmune Hypoparathyroidism
Paresthesia, Anxiety, Depression, Laryngeal dystonia, Irritability ORPHA:36913
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response OMIM:618201
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Dystonia-Aphonia Syndrome
Generalized dystonia, Cognitive impairment, Oromandibular dystonia, Anxiety ORPHA:412217
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures
Gait ataxia, Paroxysmal bursts of laughter, Aggressive behavior, Choreoathetosis, Happy demeanor,... OMIM:619580
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Tay-Sachs Disease
Exaggerated startle response, Memory impairment, Anxiety, Dysmetria, Tremor, Laryngeal dystonia, ... ORPHA:845
Sandhoff Disease
Exaggerated startle response, Progressive psychomotor deterioration, Impaired temperature sensati... OMIM:268800
Adiposis Dolorosa
Memory impairment, Paresthesia, Depression, Anxiety ORPHA:36397
Pyruvate Dehydrogenase E2 Deficiency
Arm dystonia, Dementia, Paroxysmal dystonia, Anxiety ORPHA:79244
Usher Syndrome
Cognitive impairment, Vestibular areflexia, Ataxia, Depression, Anxiety ORPHA:886
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Hyperactivity ORPHA:2157
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Hyperactivity, Aggressive behavior, Self-injurious behavior, Attention deficit hyperactivity diso... ORPHA:449291
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Aggressive behavior, Attention deficit hyperactivity disorder OMIM:610042
Acth-Independent Macronodular Adrenal Hyperplasia
Emotional lability, Anxiety, Depression, Mental deterioration OMIM:219080
Porphyria Due To Ala Dehydratase Deficiency
Abnormal fear/anxiety-related behavior, Apathy, Depression, Anxiety ORPHA:100924
Pigmented Nodular Adrenocortical Disease, Primary, 2
Emotional lability, Anxiety, Depression, Mental deterioration OMIM:610475
Progressive Non-Fluent Aphasia
Frontotemporal dementia, Depression, Anxiety, Mental deterioration, Memory impairment ORPHA:100070
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
Hyperekplexia 1
Exaggerated startle response OMIM:149400
Blepharospasm, Hair-pulling, Limb dystonia, Self-mutilation of tongue and lips due to involuntary... ORPHA:2388
Pigmented Nodular Adrenocortical Disease, Primary, 1
Emotional lability, Anxiety, Depression, Mental deterioration OMIM:610489
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Exaggerated startle response OMIM:608800
Sandhoff Disease, Infantile Form
Exaggerated startle response ORPHA:309155
Autosomal Dominant Hypocalcemia
Paresthesia, Writer's cramp, Emotional lability, Depression, Anxiety ORPHA:428
Congenital Heart Defects, Multiple Types, 7
Depression, Anxiety OMIM:618780
Asparagine Synthetase Deficiency
Exaggerated startle response OMIM:615574
Microcephaly 29, Primary, Autosomal Recessive
Hyperactivity, Emotional lability OMIM:620047
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Exaggerated startle response, Cognitive impairment OMIM:617527
Nmda Receptor Encephalitis
Chorea, Memory impairment, Hypersexuality, Oculogyric crisis, Choreoathetosis, Depression, Anxiet... ORPHA:217253
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Gm1 Gangliosidosis Type 1
Exaggerated startle response, Dystonia ORPHA:79255
Plaa-Associated Neurodevelopmental Disorder
Exaggerated startle response, Dystonia ORPHA:521426
Pituitary Adenoma 4, Acth-Secreting
Abnormal fear/anxiety-related behavior, Emotional lability OMIM:219090
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response OMIM:253800
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear/anxiety-related behavior, Aggressive behavior, Social and occupational deterioratio... ORPHA:353281
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear/anxiety-related behavior, Aggressive behavior, Social and occupational deterioratio... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear/anxiety-related behavior, Aggressive behavior, Social and occupational deterioratio... ORPHA:353277
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Exaggerated startle response, Dystonia ORPHA:438213
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response OMIM:619522


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ptprg

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ptprg.

No publications found that use IMPC mice or data for Ptprg.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Ptprgtm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Ptprgtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ptprgtm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter