The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|preweaning lethality, incomplete penetrance||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||0.00|
|improved glucose tolerance||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||2.27×10-05|
|increased bone mineral content||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||7.24×10-05|
|increased lean body mass||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||2.67×10-05|
|increased leukocyte cell number||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||6.54×10-06|
|increased circulating iron level||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||1.92×10-05|
|decreased total body fat amount||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||6.92×10-05|
|decreased grip strength||Ptprdtm2a(KOMP)Wtsi||HOM||Early adult||9.02×10-08|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Legacy Phenotype Associated Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ptprd by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ptprd.
There are 9 publications which use IMPC produced mice or data.
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|MGI Allele||Allele Type||Produced|
|Ptprdtm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Ptprdtm470565(L1L2_GT0_LF2A_LacZ_BetactP_neo)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
|Ptprdtm2a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Ptprdtm2e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|