Gene: Psph

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Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Psphtm1a(EUCOMM)Hmgu HOM Early adult 0.00
abnormal embryo size Psphtm1.1(KOMP)Vlcg HOM E15.5 0.00
preweaning lethality, complete penetrance Psphtm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased erythrocyte cell number Psphtm1a(EUCOMM)Hmgu HET Early adult 2.56×10-05
abnormal skin coloration Psphtm1.1(KOMP)Vlcg HOM E15.5 0.00
small adrenal glands Psphtm1.1(KOMP)Vlcg HET Early adult 0.00
abnormal embryo size Psphtm1.1(KOMP)Vlcg HET E12.5 0.00
abnormal eye morphology Psphtm1.1(KOMP)Vlcg HET E12.5 0.00
increased circulating bilirubin level Psphtm1.1(KOMP)Vlcg HET Early adult 2.14×10-06
increased circulating aspartate transaminase level Psphtm1a(EUCOMM)Hmgu HET Early adult 8.42×10-05
decreased circulating triglyceride level Psphtm1.1(KOMP)Vlcg HET Early adult 8.02×10-11
abnormal placenta size Psphtm1.1(KOMP)Vlcg HOM E12.5 0.00
abnormal craniofacial morphology Psphtm1.1(KOMP)Vlcg HOM E15.5 0.00
abnormal heart morphology Psphtm1.1(KOMP)Vlcg HOM E15.5 0.00
abnormal abdominal wall morphology Psphtm1.1(KOMP)Vlcg HOM E15.5 0.00
thrombocytopenia Psphtm1.1(KOMP)Vlcg HET Early adult 1.44×10-05
abnormal craniofacial morphology Psphtm1.1(KOMP)Vlcg HOM E12.5 0.00
abnormal eye morphology Psphtm1.1(KOMP)Vlcg HOM E12.5 0.00
abnormal sinus arrhythmia Psphtm1.1(KOMP)Vlcg HET Early adult 1.48×10-05
abnormal embryo size Psphtm1.1(KOMP)Vlcg HOM E12.5 0.00
cardiovascular system phenotype Psphtm1.1(KOMP)Vlcg HET Early adult 3.36×10-05
pallor Psphtm1.1(KOMP)Vlcg HOM E15.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589)  (1/2) N/A
Aorta 2 No  (1/589) N/A
Brain 2 No  (3/589)  (2/2)  Section images
Brainstem 2 No  (2/589)  (2/2) N/A
Brown adipose tissue 1 No  (1/1) N/A
Cartilage tissue 2 No  (1/2) N/A
Cerebellum 2 No  (3/589)  (2/2)  Section images
Cerebral cortex 2 No  (2/589)  (2/2) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No  (1/589) N/A
Hippocampus 2 No  (3/589)  (2/2) N/A
Hypothalamus 2 No  (2/589)  (2/2) N/A
Kidney 2 No  (20/589)  (1/2) N/A
Large intestine 2 No  (10/589)  (2/2) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No  (1/589) N/A
Lung 2 No  (1/589) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/589)  (2/2) N/A
Ovary 2 No  (1/589)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/589)  (2/2)  Section images
Peripheral nervous system 2 No  (1/589) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/589)  (2/2) N/A
Spinal cord 2 No  (2/589) N/A
Spleen 2 No  (2/589)  (1/2) N/A
Stomach 2 No  (13/589) N/A
Striatum 2 No  (3/589)  (1/2) N/A
Testis 2 No  (5/589) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (16/589)  (1/2) N/A
Trachea 2 No  (2/589) N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 5  (6/506)  (2/5) N/A
Central nervous system ganglion 2  (1/74) N/A
Ear 5  (1/506) N/A
Embryo 5  (1/507)  (2/5) N/A
Eye 5  (1/506)  (2/5) N/A
Foot 5  (1/506)  (2/5) N/A
Forebrain 5  (1/506)  (2/5) N/A
Forelimb 5  (1/506)  (2/5) N/A
Gut 2  (1/60) N/A
Hand 5  (1/505)  (2/5) N/A
Head 5  (5/506) N/A
Heart 5  (1/506)  (2/5) N/A
Hindbrain 5  (6/506)  (2/5) N/A
Hindlimb 5  (1/505)  (2/5) N/A
Liver 5  (1/506)  (2/5) N/A
Lung 5  (1/502) N/A
Mandibular process 5  (1/506)  (2/5) N/A
Maxillary process 5  (1/506)  (2/5) N/A
Midbrain 5  (1/506)  (2/5) N/A
Nose 2  (1/74)  (2/2) N/A
Oral cavity 5  (1/506) N/A
Skeleton 2  (1/74)  (2/2) N/A
Skin 5  (1/506) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Tail 5  (1/506)  (2/5) N/A
Tail somite 5  (1/506) N/A
Trachea 2  (1/60) N/A
Urinary system 2  (1/60) N/A

 Associated Images

X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
Adult LacZ: LacZ Images Section
10 Images
Embryo LacZ: LacZ images wholemount
20 Images
Ear epidermis immunophenotyping
12 Images
DSS Histology
8 Images
Anti-nuclear antibody assay
6 Images
Eye Morphology: Images Slit Lamp
3 Images
Legacy Phenotype Associated Images

View all 80 images

 Disease Models

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MGI Allele Allele Type Produced
Psphtm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Psphtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice
Psphtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells