Gene: Psph

Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating triglyceride level Psphtm1.1(KOMP)Vlcg HET postnatal 2.46×10-06
abnormal embryo size Psphtm1.1(KOMP)Vlcg HOM embryonic day 12.5 0.00
anophthalmia Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal embryo size Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal heart morphology Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal craniofacial morphology Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
thrombocytopenia Psphtm1.1(KOMP)Vlcg HET postnatal 2.16×10-05
preweaning lethality, complete penetrance Psphtm1a(EUCOMM)Hmgu HOM n/a 0.00
abnormal eye morphology Psphtm1.1(KOMP)Vlcg HOM embryonic day 12.5 0.00
pale yolk sac Psphtm1.1(KOMP)Vlcg HOM embryonic day 12.5 0.00
preweaning lethality, complete penetrance Psphtm1.1(KOMP)Vlcg HOM n/a 0.00
pallor Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
small adrenal glands Psphtm1.1(KOMP)Vlcg HET postnatal 0.00
microphthalmia Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
edema Psphtm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
prenatal lethality prior to heart atrial septation Psphtm1.1(KOMP)Vlcg HOM embryonic day 14.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (1/2) N/A
Aorta 2 No N/A
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 1 No  (1/1) N/A
Cartilage tissue 2 No  (1/2) N/A
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (1/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2)  Section images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584)  (1/2) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (1/2) N/A
Testis 2 No  (2/584) N/A
Thymus 2 No  (1/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 5  (6/485)  (2/5) N/A
Central nervous system ganglion 2  (1/51) N/A
Ear 5  (1/485) N/A
Embryo 5  (1/485)  (2/5) N/A
Eye 5  (1/485)  (2/5) N/A
Foot 5  (1/485)  (2/5) N/A
Forebrain 5  (1/485)  (2/5) N/A
Forelimb 5  (1/485)  (2/5) N/A
Gut 2  (1/50) N/A
Hand 5  (1/485)  (2/5) N/A
Head 5  (5/485) N/A
Heart 5  (1/485)  (2/5) N/A
Hindbrain 5  (6/485)  (2/5) N/A
Hindlimb 5  (1/485)  (2/5) N/A
Liver 5  (1/485)  (2/5) N/A
Lung 5  (1/485) N/A
Mandibular process 5  (1/485)  (2/5) N/A
Maxillary process 5  (1/485)  (2/5) N/A
Midbrain 5  (1/485)  (2/5) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 5  (1/485) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 5  (1/485) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 5  (1/485)  (2/5) N/A
Tail somite 5  (1/485) N/A
Trachea 2  (1/50) N/A
Urinary system 2  (1/50) N/A

 Associated Images

Anti-nuclear antibody assay
6 Images
DSS Histology
8 Images
Embryo LacZ: LacZ images wholemount
12 Images
Gross Morphology Embryo E14.5-E15.5
9 Images
X-ray: XRay Images Dorso Ventral
57 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Lateral Orientation
41 Images
Combined SHIRPA and Dysmorphology
1 Images
Adult LacZ: LacZ Images Section
10 Images
X-ray: XRay Images Skull Lateral Orientation
27 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Psphtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice
Psphtm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Psphtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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