Gene Summary

Name:
phosphorylase kinase alpha 2
Synonyms:
k,  Phk,  6330505C01Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Section images heterozygote 100% (1 of 1)
Adrenal gland  Section images homozygote 100% (1 of 1)
Aorta  Section images heterozygote 100% (1 of 1)
Aorta  Section images homozygote 100% (1 of 1)
Brain  Section images heterozygote 100% (1 of 1)
Brain  Section images homozygote 100% (1 of 1)
Brainstem  Section images homozygote 100% (1 of 1)
Brown adipose tissue  Section images heterozygote 100% (1 of 1)
Brown adipose tissue  Section images homozygote 100% (1 of 1)
Cartilage tissue  Section images homozygote 100% (1 of 1)
Cerebellum  Section images homozygote 100% (1 of 1)
Cerebral cortex  Section images homozygote 100% (1 of 1)
Epididymis  Section images homozygote 0.0% (0 of 1)
Esophagus  Section images homozygote 100% (1 of 1)
Heart  Section images heterozygote 100% (1 of 1)
Heart  Section images homozygote 100% (1 of 1)
Hippocampus  Section images homozygote 100% (1 of 1)
Hypothalamus  Section images homozygote 100% (1 of 1)
Kidney  Section images heterozygote 100% (1 of 1)
Kidney  Section images homozygote 100% (1 of 1)
Large intestine  Section images homozygote 100% (1 of 1)
Liver  Section images heterozygote 100% (1 of 1)
Liver  Section images homozygote 100% (1 of 1)
Lung  Section images heterozygote 100% (1 of 1)
Lung  Section images homozygote 100% (1 of 1)
Mammary gland  Section images heterozygote 100% (1 of 1)
Midbrain  Section images homozygote 100% (1 of 1)
Olfactory lobe  Section images homozygote 100% (1 of 1)
Ovary  Section images heterozygote 100% (1 of 1)
Oviduct  Section images heterozygote 100% (1 of 1)
Pancreas  Section images heterozygote 100% (1 of 1)
Pancreas  Section images homozygote 100% (1 of 1)
Peripheral nervous system  Section images homozygote 100% (1 of 1)
Peyer's patch  Section images homozygote Ambiguous
Pituitary gland  Section images homozygote 100% (1 of 1)
Skeletal muscle  Section images heterozygote 100% (1 of 1)
Skeletal muscle  Section images homozygote 100% (1 of 1)
Skin  Section images homozygote 100% (1 of 1)
Small intestine  Section images homozygote 100% (1 of 1)
Spinal cord  Section images homozygote 100% (1 of 1)
Spleen  Section images heterozygote 100% (1 of 1)
Spleen  Section images homozygote 100% (1 of 1)
Stomach  Section images homozygote 100% (1 of 1)
Striatum  Section images homozygote 100% (1 of 1)
Submandibular gland  Section images heterozygote 100% (1 of 1)
Submandibular gland  Section images homozygote 100% (1 of 1)
Testis  Section images homozygote 100% (1 of 1)
Thalamus  Section images homozygote 100% (1 of 1)
Thymus  Section images homozygote 100% (1 of 1)
Thyroid gland  Section images homozygote 100% (1 of 1)
Trachea  Section images heterozygote 100% (1 of 1)
Trachea  Section images homozygote 100% (1 of 1)
Urinary bladder  Section images homozygote 100% (1 of 1)
Uterus  Section images heterozygote 100% (1 of 1)
Vascular system  Section images heterozygote 100% (1 of 1)
Vascular system  Section images homozygote 100% (1 of 1)
White adipose tissue  Section images heterozygote 100% (1 of 1)
Brainstem N/A heterozygote 100% (1 of 1)
Cartilage tissue N/A heterozygote 0.0% (0 of 1)
Cerebellum N/A heterozygote 100% (1 of 1)
Cerebral cortex N/A heterozygote 100% (1 of 1)
Epididymis N/A heterozygote Not available
Esophagus N/A heterozygote Not available
Eye N/A heterozygote Not available
Eye N/A homozygote Not available
Hippocampus N/A heterozygote 100% (1 of 1)
Hypothalamus N/A heterozygote 100% (1 of 1)
Large intestine N/A heterozygote 100% (1 of 1)
Lower urinary tract N/A heterozygote Not available
Lower urinary tract N/A homozygote Not available
Lymph node N/A heterozygote 0.0% (0 of 1)
Lymph node N/A homozygote 0.0% (0 of 1)
Mammary gland N/A homozygote Not available
Midbrain N/A heterozygote 100% (1 of 1)
Olfactory lobe N/A heterozygote 100% (1 of 1)
Ovary N/A homozygote Not available
Oviduct N/A homozygote Not available
Peripheral nervous system N/A heterozygote 100% (1 of 1)
Peyer's patch N/A heterozygote Ambiguous
Pituitary gland N/A heterozygote 100% (1 of 1)
Prostate gland N/A heterozygote Not available
Prostate gland N/A homozygote Not available
Skin N/A heterozygote 100% (1 of 1)
Small intestine N/A heterozygote 100% (1 of 1)
Spinal cord N/A heterozygote 100% (1 of 1)
Stomach N/A heterozygote 100% (1 of 1)
Striatum N/A heterozygote 100% (1 of 1)
Testis N/A heterozygote Not available
Thalamus N/A heterozygote 100% (1 of 1)
Thymus N/A heterozygote 100% (1 of 1)
Thyroid gland N/A heterozygote 100% (1 of 1)
Urinary bladder N/A heterozygote 100% (1 of 1)
Uterus N/A homozygote Not available
Vesicular gland N/A heterozygote Not available
Vesicular gland N/A homozygote Not available
White adipose tissue N/A homozygote 100% (1 of 1)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Embryo N/A heterozygote 100% (2 of 2)
Embryo N/A homozygote Ambiguous
Brain N/A heterozygote 100% (2 of 2)
Brain N/A homozygote Ambiguous
Dorsal root ganglion N/A heterozygote 100% (2 of 2)
Dorsal root ganglion N/A homozygote Ambiguous
Ear N/A heterozygote 0.0% (0 of 2)
Ear N/A homozygote Ambiguous
Eye N/A heterozygote 100% (2 of 2)
Eye N/A homozygote Ambiguous
Footplate N/A heterozygote 0.0% (0 of 2)
Footplate N/A homozygote Ambiguous
Forebrain N/A heterozygote 100% (2 of 2)
Forebrain N/A homozygote Ambiguous
Forelimb N/A heterozygote 100% (2 of 2)
Forelimb N/A homozygote Ambiguous
Fronto-nasal process N/A heterozygote Ambiguous
Fronto-nasal process N/A homozygote Ambiguous
Handplate N/A heterozygote 0.0% (0 of 2)
Handplate N/A homozygote Ambiguous
Head N/A heterozygote 100% (2 of 2)
Head N/A homozygote Ambiguous
Heart N/A heterozygote 100% (2 of 2)
Heart N/A homozygote Ambiguous
Hindbrain N/A heterozygote 100% (2 of 2)
Hindbrain N/A homozygote Ambiguous
Hindlimb N/A heterozygote 100% (2 of 2)
Hindlimb N/A homozygote Ambiguous
Liver N/A heterozygote 0.0% (0 of 2)
Liver N/A homozygote Ambiguous
Lung N/A heterozygote Ambiguous
Lung N/A homozygote Ambiguous
Mandibular process N/A heterozygote 100% (2 of 2)
Mandibular process N/A homozygote Ambiguous
Maxillary process N/A heterozygote 100% (2 of 2)
Maxillary process N/A homozygote Ambiguous
Midbrain N/A heterozygote 100% (2 of 2)
Midbrain N/A homozygote Ambiguous
Nose N/A heterozygote 0.0% (0 of 2)
Nose N/A homozygote Ambiguous
Oral cavity N/A heterozygote Ambiguous
Oral cavity N/A homozygote Ambiguous
Skin N/A heterozygote Ambiguous
Skin N/A homozygote Ambiguous
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A homozygote Ambiguous
Tail somite N/A heterozygote Ambiguous
Tail somite N/A homozygote Ambiguous
Tail N/A heterozygote 100% (2 of 2)
Tail N/A homozygote Ambiguous

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
heart 0.34% (2 of 584)
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.34% (2 of 584)
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
striatum 0.51% (3 of 584)
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thalamus 0.0%
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
trachea 0.51% (3 of 584)
urinary bladder 0.0%
uterus 0.0%
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.18% (6 of 507)
dorsal root ganglion 1.69% (1 of 59)
ear 0.2% (1 of 507)
embryo 0.2% (1 of 508)
eye 0.2% (1 of 507)
footplate 0.2% (1 of 507)
forebrain 0.2% (1 of 507)
forelimb 0.2% (1 of 507)
fronto-nasal process 1.67% (1 of 60)
handplate 0.2% (1 of 507)
head 0.99% (5 of 507)
heart 0.2% (1 of 507)
hindbrain 1.18% (6 of 507)
hindlimb 0.2% (1 of 507)
liver 0.2% (1 of 502)
lung 0.2% (1 of 502)
mandibular process 0.2% (1 of 507)
maxillary process 0.2% (1 of 507)
midbrain 0.2% (1 of 507)
nose 1.3% (1 of 77)
oral cavity 0.2% (1 of 502)
skin 0.2% (1 of 507)
spinal cord 1.41% (1 of 71)
tail 0.2% (1 of 507)
tail somite group 0.2% (1 of 507)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Section

57 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Sleep Wake

Wake state (bmp file)

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Embryo LacZ

LacZ images wholemount

12 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

Electroretinography 2

Rod and cone PDF

4 Images

Human diseases caused by Phka2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Phka2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Glycogen Storage Disease Ixa1
OMIM:306000
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
ORPHA:264580

The table below shows human diseases predicted to be associated to Phka2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Glycogen Storage Disease Ixa1
OMIM:306000
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
ORPHA:264580

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Phka2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Phka2.

No publications found that use IMPC mice or data for Phka2.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Phka2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Phka2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Phka2tm40612(L1L2_gt0) Targeting vectors

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