Pgd | phosphogluconate dehydrogenase
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
abnormal bone structure | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.77x10-8 | ||
increased circulating aspartate transaminase level | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.7x10-13 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
increased bone mineral content | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.2x10-7 | ||
abnormal bone mineralization | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.04x10-11 | ||
increased lactate dehydrogenase level | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.84x10-9 | ||
absent testes | 1 supporting dataset | Pgdtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.88x10-7 |
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External links
No external links available for Pgd.
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Pgdtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Pgdtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |